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The University of Oklahoma

2 ARTICLES PUBLISHED IN JoVE

Bioengineering

Biaxial Mechanical Characterizations of Atrioventricular Heart Valves

Colton Ross^*1, Devin Laurence^*1, Yi Wu¹, Chung-Hao Lee^1,2

¹Biomechanics and Biomaterials Design Laboratory (BBDL), School of Aerospace and Mechanical Engineering, The University of Oklahoma, ²Institute for Biomedical Engineering, Science and Technology (IBEST), The University of Oklahoma

This protocol involves characterizations of atrioventricular valve leaflets with force-controlled, displacement-controlled, and stress-relaxation biaxial mechanical testing procedures. Results acquired with this protocol can be used for constitutive model development to simulate the mechanical behavior of functioning valves under a finite element simulation framework.

Bioengineering

Layer Microdissection of Tricuspid Valve Leaflets for Biaxial Mechanical Characterization and Microstructural Quantification

Katherine M. Casey¹, Devin W. Laurence¹, Mulan Tang¹, Chung-Hao Lee^1,2

This protocol describes the biaxial mechanical characterization, polarized spatial frequency domain imaging-based collagen quantification, and microdissection of tricuspid valve leaflets. The provided method elucidates how the leaflet layers contribute to the holistic leaflet behaviors.