The Brain Institute at Florida Atlantic University
3 ARTICLES PUBLISHED IN JoVE
Medicine
Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment
Mei Wang 1, Zhengluan Liao 2, Dewang Mao 3, Qi Zhang 1, Yumei Li 3, Enyan Yu 2, Zhongxiang Ding 3
1Zhejiang Chinese Medical University, 2Department of Psychiatry, Zhejiang Provincial People's Hospital, 3Department of Radiology, Zhejiang Provincial People's Hospital
Based on resting-state functional magnetic resonance imaging with Granger causality analysis, we investigated the alterations in the directed functional connectivity between the posterior cingulate cortex and whole brain in patients with Alzheimer's Disease (AD), patients with Mild Cognitive Impairment (MCI), and healthy controls.
Behavior
An Automated T-maze Based Apparatus and Protocol for Analyzing Delay- and Effort-based Decision Making in Free Moving Rodents
Qi Zhang 1,2, Yuki Kobayashi 1, Hiromichi Goto 1, Shigeyoshi Itohara 1
1Laboratory of Behavioral Genetics, Center for Brain Science, RIKEN, 2Faculty of Human Science, University of Tsukuba
This article introduces an automated T-maze apparatus that we invented, and a protocol based on this apparatus for analyzing delay-based decision making and effort-based decision making in free moving rodents.
Neuroscience
Measuring Membrane Lipid Turnover with the pH-sensitive Fluorescent Lipid Analog ND6
Shahriar Alamgir 1,2, Oliver B. Pelletier 1,2, Deborah Thomas 3, Vicente Rubio 3, Maciej J. Stawikowski 3, Qi Zhang 1,2
1The Brain Institute at Florida Atlantic University, 2Department of Biomedical Sciences, Florida Atlantic University, 3Department of Chemistry and Biochemistry, Florida Atlantic University
This protocol presents a fluorescence imaging method that uses a class of pH-sensitive lipid fluorophores to monitor lipid membrane trafficking during cell exocytosis and the endocytosis cycle.
