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The Brain Institute at Florida Atlantic University

3 ARTICLES PUBLISHED IN JoVE

Medicine

Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment

Mei Wang¹, Zhengluan Liao², Dewang Mao³, Qi Zhang¹, Yumei Li³, Enyan Yu², Zhongxiang Ding³

¹Zhejiang Chinese Medical University, ²Department of Psychiatry, Zhejiang Provincial People's Hospital, ³Department of Radiology, Zhejiang Provincial People's Hospital

Based on resting-state functional magnetic resonance imaging with Granger causality analysis, we investigated the alterations in the directed functional connectivity between the posterior cingulate cortex and whole brain in patients with Alzheimer's Disease (AD), patients with Mild Cognitive Impairment (MCI), and healthy controls.

Behavior

An Automated T-maze Based Apparatus and Protocol for Analyzing Delay- and Effort-based Decision Making in Free Moving Rodents

Qi Zhang^1,2, Yuki Kobayashi¹, Hiromichi Goto¹, Shigeyoshi Itohara¹

¹Laboratory of Behavioral Genetics, Center for Brain Science, RIKEN, ²Faculty of Human Science, University of Tsukuba

This article introduces an automated T-maze apparatus that we invented, and a protocol based on this apparatus for analyzing delay-based decision making and effort-based decision making in free moving rodents.

Neuroscience

Measuring Membrane Lipid Turnover with the pH-sensitive Fluorescent Lipid Analog ND6

Shahriar Alamgir^1,2, Oliver B. Pelletier^1,2, Deborah Thomas³, Vicente Rubio³, Maciej J. Stawikowski³, Qi Zhang^1,2

¹The Brain Institute at Florida Atlantic University, ²Department of Biomedical Sciences, Florida Atlantic University, ³Department of Chemistry and Biochemistry, Florida Atlantic University

This protocol presents a fluorescence imaging method that uses a class of pH-sensitive lipid fluorophores to monitor lipid membrane trafficking during cell exocytosis and the endocytosis cycle.