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University of Prince Edward Island

2 ARTICLES PUBLISHED IN JoVE

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Medicine

Early Pathological and Magnetic Resonance Detection of Cerebral Injury Using a Rat Model of Neonatal Hypoxic Ischemic Encephalopathy
Michael G. Melek 1, Rheal Towner 2,3, Johannes Kung 1, Debra Saunders 4, Michelle Zales 3,4, Faizah Bhatti 1,3
1Department of Pediatrics, University of Oklahoma Health Sciences Center, 2Department of Chemistry, University of Prince Edward Island, 3Center for Neuroscience, University of Oklahoma Health Sciences Center, 4Oklahoma Medical Research Foundation

The present protocol describes a rodent model of newborn hypoxic-ischemic injury for identifying early changes in cerebral tissue by gross morphology and magnetic resonance imaging. This has benefits over existing models, which can be used to study late injury but do not allow the evaluation of reproducible early changes.

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Biochemistry

Bioassay-Guided Identification of Natural Products for Biocontrol by Thin Layer Chromatography-Direct Bioautography
Leah Gauthier 1,2, Brian D. Wagner 2, Sue Boyetchko 3, Christopher W. Kirby 1,2
1Charlottetown Research and Development Centre, Agriculture and Agri-Food Canada, 2Department of Chemistry, University of Prince Edward Island, 3Saskatoon Research and Development Centre, Agriculture and Agri-Food Canada

We describe the use of thin-layer chromatography direct bioautography assay and liquid chromatography-mass spectrometry to identify microbial natural products that display antagonism against fungal pathogens using the pathogen Sclerotinia sclerotiorum and biopesticidal Bacillus isolates as a model system.

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