JoVE Journal

Medicine

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Dioscin 通过抑制体内 B 细胞活化和减少体外半乳糖缺乏型 IgA1 的产生来缓解 IgA 肾病

副本

本研究为用薯菌根瘤 (DNR) 的活性成分薯蓣星 (DIO) 治疗免疫球蛋白 A 肾病 (IgAN) 提供了实验数据,并为研究体内和体外草药的作用和潜在机制提供了范例。

此视频中的章节

0:00

Introduction

2:27

Preparing IgAN Model Mice for Dioscin‐Mediated IgA Nephropathy Alleviation Experiment

3:38

,Preparing Paraffin Sections of Kidney and Peyer's Patch Isolated from an IgAN Murine Model for Histological and Immunohistochemical Analyses

4:38

Histological Analysis of Kidney Tissue and Peyer's Patch Isolated from an IgAN Murine Model

6:16

Immunohistochemical Analysis of Peyer's Patch Isolated from an IgAN Murine Model

8:44

Assays for Screening Safe Concentrations and Effects of DIO on Normal DAKIKI Cells

10:51

Detecting the Effect of DIO on the mRNA and Protein Levels of C1GALT1 and Cosmc in DAKIKI Cells

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