This protocol can be used to measure the membrane potential of normal and diseased blood vessels and to evaluate pharmacological agents that modulate membrane potential, vascular tone, and blood flow. The membrane potentials generated from this te
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The primary goal of this article is to provide details of how to record membrane potential (Vm) from the middle cerebral artery using the microelectrode impalement method. The cannulated middle cerebral artery is equilibrated to gain myogenic tone, and the vessel wall is impaled using high resistance microelectrodes.