Translating Synthetic Lethal Gene Pairs to Human Orthologs
3:20
Mapping Synthetic Lethal Interaction Partners to Drugs
4:28
Establish the Set of Currently Tested Drug Combinations in Clinical Trials
4:45
Testing Proposed Drug Combinations In Vitro
5:28
Results: Proposed Novel Drug Combinations for Ovarian and Breast Cancer
6:37
Conclusion
Transcript
A synthetic lethal interaction between two genes occurs when a single knockdown of either one does not affect cell viability but knockdown of both synthetic lethal partners leads to loss of cell viability or cell death. Combining heterogeneous dat
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Large genetic screens in model organisms have led to the identification of negative genetic interactions. Here, we describe a data integration workflow using data from genetic screens in model organisms to delineate drug combinations targeting synthetic lethal interactions in cancer.
