A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions

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4.1K Views

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07:40 min

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May 27th, 2021

DOI :

10.3791/60328-v

May 27th, 2021

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Maximilian Marhold¹, Andreas Heinzel², Almas Merchant¹, Paul Perco³, Michael Krainer¹

¹Department of Internal Medicine I - Division of Oncology, Comprehensive Cancer Center, Medical University of Vienna, ²Department of Nephrology, Medical University of Vienna, ³Department of Internal Medicine IV, Medical University Innsbruck

Podsumowanie

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Negative Genetic Interactions

Computational Predictions

Breast Cancer

Ensembl BioMart

Orthologous Gene Pairs

Model Organisms

Gene Interactions

Rozdziały w tym wideo

0:04

Introduction

1:03

Retrieving Synthetic Lethal Gene Pairs

1:48

Translating Synthetic Lethal Gene Pairs to Human Orthologs

3:20

Mapping Synthetic Lethal Interaction Partners to Drugs

4:28

Establish the Set of Currently Tested Drug Combinations in Clinical Trials

4:45

Testing Proposed Drug Combinations In Vitro

5:28

Results: Proposed Novel Drug Combinations for Ovarian and Breast Cancer

6:37

Conclusion

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