Focused Ultrasound in combination with circulating micro-bubbles can be used to provide temporary millimeter size openings in the blood-brain barrier. This enables non-invasive delivery of systemically circulating agents to target brain regions. T
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Focused ultrasound with microbubble agents can open the blood brain barrier focally and transiently. This technique has been used to deliver a wide range of agents across the blood brain barrier. This article provides a detailed protocol for the localized delivery to the rodent brain with or without MRI guidance.