<meta charset="utf8"></head><body>准分子激光多焦点双非球面消融术用于老花眼矫正

<ol>
	<li>Wolffsohn, J. S., Davies, L. N. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Presbyopia:+Effectiveness+of+correction+strategies.">Presbyopia: Effectiveness of correction strategies.</a> Prog Retin Eye Res. 68, 124-143 (2019).</li><li>Frick, K. D., Joy, S. M., Wilson, D. A., Naidoo, K. S., Holden, B. A. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=The+global+burden+of+potential+productivity+loss+from+uncorrected+presbyopia.">The global burden of potential productivity loss from uncorrected presbyopia.</a> Ophthalmology. 122 (8), 1706-1710 (2015).</li><li>Nanavaty, M. A., Daya, S. M. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Refractive+lens+exchange+versus+phakic+intraocular+lenses.">Refractive lens exchange versus phakic intraocular lenses.</a> Curr Opin Ophthalmol. 23 (1), 54-61 (2012).</li><li>Soler Tom&#225;s, J. R., Fuentes-P&#225;ez, G., Burillo, S. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Symmetrical+versus+asymmetrical+PresbyLASIK:+Results+after+18+months+and+patient+satisfaction.">Symmetrical versus asymmetrical PresbyLASIK: Results after 18 months and patient satisfaction.</a> Cornea. 34 (6), 651-657 (2015).</li><li>Shetty, R., Brar, S., Sharma, M., Dadachanji, Z., Lalgudi, V. G. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=PresbyLASIK:+A+review+of+PresbyMAX,+Supracor,+and+laser+blended+vision:+Principles,+planning,+and+outcomes.">PresbyLASIK: A review of PresbyMAX, Supracor, and laser blended vision: Principles, planning, and outcomes.</a> Indian J Ophthalmol. 68 (12), 2723-2731 (2020).</li><li>Pinelli, R., Ortiz, D., Simonetto, A., Bacchi, C., Sala, E., Ali&#243;, J. L. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Correction+of+presbyopia+in+hyperopia+with+a+center-distance,+paracentral-near+technique+using+the+Technolas+217z+platform.">Correction of presbyopia in hyperopia with a center-distance, paracentral-near technique using the Technolas 217z platform.</a> J Refract Surg. 24 (5), 494-500 (2008).</li><li>Ali&#243;, J. L., Chaubard, J. J., Caliz, A., Sala, E., Patel, S. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Correction+of+presbyopia+by+technovision+central+multifocal+LASIK+(presbyLASIK).">Correction of presbyopia by technovision central multifocal LASIK (presbyLASIK).</a> J Refract Surg. 22 (5), 453-460 (2006).</li><li>Vargas-Fragoso, V., Ali&#243;, J. L. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Corneal+compensation+of+presbyopia:+PresbyLASIK:+An+updated+review.">Corneal compensation of presbyopia: PresbyLASIK: An updated review.</a> Eye Vis (Lond). 4, 11 (2017).</li><li>Pallikaris, I. G., Panagopoulou, S. I. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=PresbyLASIK+approach+for+the+correction+of+presbyopia.">PresbyLASIK approach for the correction of presbyopia.</a> Curr Opin Ophthalmol. 26 (4), 265-272 (2015).</li><li>Ryu, S., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Presbyopia+correction+using+the+monocular+bi-aspheric+ablation+profile+in+myopic+eyes.">Presbyopia correction using the monocular bi-aspheric ablation profile in myopic eyes.</a> J Cataract Refract Surg. 49 (1), 69-75 (2023).</li><li>Fu, D., Zhao, J., Zeng, L., Zhou, X. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=One+year+outcome+and+satisfaction+of+presbyopia+correction+using+the+PresbyMAX&#174;+monocular+ablation+profile.">One year outcome and satisfaction of presbyopia correction using the PresbyMAX&#174; monocular ablation profile.</a> Front Med (Lausanne). 7, 589275 (2020).</li><li>Fu, D., Zhao, J., Zhou, X. T. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Objective+optical+quality+and+visual+outcomes+after+the+PresbyMAX+monocular+ablation+profile.">Objective optical quality and visual outcomes after the PresbyMAX monocular ablation profile.</a> Int J Ophthalmol. 13 (7), 1060-1065 (2020).</li><li>Braun, E. H., Lee, J., Steinert, R. F. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Monovision+in+LASIK.">Monovision in LASIK.</a> Ophthalmology. 115 (7), 1196-1202 (2008).</li><li>Kohnen, T., B&#246;hm, M., Herzog, M., Hemkeppler, E., Petermann, K., Lwowski, C. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Near+visual+acuity+and+patient-reported+outcomes+in+presbyopic+patients+after+bilateral+multifocal+aspheric+laser+in+situ+keratomileusis+excimer+laser+surgery.">Near visual acuity and patient-reported outcomes in presbyopic patients after bilateral multifocal aspheric laser in situ keratomileusis excimer laser surgery.</a> J Cataract Refract Surg. 46 (7), 944-952 (2020).</li><li>Uthoff, D., P&#246;lzl, M., Hepper, D., Holland, D. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=A+new+method+of+cornea+modulation+with+excimer+laser+for+simultaneous+correction+of+presbyopia+and+ametropia.">A new method of cornea modulation with excimer laser for simultaneous correction of presbyopia and ametropia.</a> Graefes Arch Clin Exp Ophthalmol. 250 (11), 1649-1661 (2012).</li><li>Baudu, P., Penin, F., Mosquera Arba, S. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Uncorrected+binocular+performance+after+biaspheric+ablation+profile+for+presbyopic+corneal+treatment+using+AMARIS+with+the+PresbyMAX+module.">Uncorrected binocular performance after biaspheric ablation profile for presbyopic corneal treatment using AMARIS with the PresbyMAX module.</a> Am J Ophthalmol. 155 (4), 636-647 (2013).</li><li>Luger, M. H., McAlinden, C., Buckhurst, P. J., Wolffsohn, J. S., Verma, S., Arba-Mosquera, S. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Presbyopic+LASIK+using+hybrid+bi-aspheric+micro-monovision+ablation+profile+for+presbyopic+corneal+treatments.">Presbyopic LASIK using hybrid bi-aspheric micro-monovision ablation profile for presbyopic corneal treatments.</a> Am J Ophthalmol. 160 (3), 493-505 (2015).</li><li>Luger, M. H., Ewering, T., Arba-Mosquera, S. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=One-year+experience+in+presbyopia+correction+with+biaspheric+multifocal+central+presbyopia+laser+in+situ+keratomileusis.">One-year experience in presbyopia correction with biaspheric multifocal central presbyopia laser in situ keratomileusis.</a> Cornea. 32 (5), 644-652 (2013).</li><li>Chan, T. C., Kwok, P. S., Jhanji, V., Woo, V. C., Ng, A. L. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Presbyopic+correction+using+monocular+bi-aspheric+ablation+profile+(PresbyMAX)+in+hyperopic+eyes:+1-year+outcomes.">Presbyopic correction using monocular bi-aspheric ablation profile (PresbyMAX) in hyperopic eyes: 1-year outcomes.</a> J Refract Surg. 33 (1), 37-43 (2017).</li><li>El Danasoury, A. M., Gamaly, T. O., Hantera, M. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Multizone+LASIK+with+peripheral+near+zone+for+correction+of+presbyopia+in+myopic+and+hyperopic+eyes:+1-year+results.">Multizone LASIK with peripheral near zone for correction of presbyopia in myopic and hyperopic eyes: 1-year results.</a> J Refract Surg. 25 (3), 296-305 (2009).</li><li>Yebra-Pimentel, E., Gonz&#225;lez-J&#233;ijome, J. M., Cervi&#241;o, A., Gir&#225;ldez, M. J., Gonz&#225;lez-P&#233;rez, J., Parafita, M. A. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Corneal+asphericity+in+a+young+adult+population.+Clinical+implications.">Corneal asphericity in a young adult population. Clinical implications.</a> Arch Soc Esp Oftalmol. 79 (8), 385-392 (2004).</li><li>Calossi, A. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Corneal+asphericity+and+spherical+aberration.">Corneal asphericity and spherical aberration.</a> J Refract Surg. 23 (5), 505-514 (2007).</li></ol>

<table><tbody><tr><td>0.9% Sodium Chloride Physiological Solution</td><td>Shandong Qidu Pharmaceutical Co., Ltd.</td><td>H37020764</td><td></td></tr><tr><td>AMARIS 1050RS Excimer Laser System</td><td>SCHWIND eye-tech-solutions,DE</td><td>https://www.eye-tech-solutions.com/amaris1050-excimer-laser</td><td></td></tr><tr><td>Compound Electrolyte Intraocular Irrigating Solution</td><td>Shenyang Xingqi Ophthalmic Co.</td><td>http://sinqi.com/html/SYXQ/202006/948671948671019061.html</td><td></td></tr><tr><td>Dexamethasone Eye Drops</td><td>Alcon-Couvreur</td><td>H20150119</td><td></td></tr><tr><td>Dextran 70</td><td>Chengdu Qingshan Likang Pharmaceutical Co.</td><td>6941684920076</td><td></td></tr><tr><td>Glycerol Eye Drops</td><td>Chengdu Qingshan Likang Pharmaceutical Co.</td><td>6941684920076</td><td></td></tr><tr><td>Hypromellose 2910</td><td>Chengdu Qingshan Likang Pharmaceutical Co.</td><td>6941684920076</td><td></td></tr><tr><td>Levofloxacin Hydrochloride Eye Drops</td><td>Shandong Bausch &amp;amp; Lomb Freda Pharmaceutical Co., Ltd</td><td>6924090700180</td><td></td></tr><tr><td>Proparacaine hydrochloride Eye Drops</td><td>Alcon-Couvreur</td><td>H20103352</td><td></td></tr><tr><td>SCHWIND Cutom Ablation Manager for Amaris</td><td>Consorzio Servizi Ortopedici,Turin,IT</td><td>N/A</td><td></td></tr><tr><td>Sirius 3D anterior segment and corneal aberration analyzer</td><td>Consorzio Servizi Ortopedici,Turin,IT</td><td>YM0020207&amp;nbsp;</td><td></td></tr><tr><td>Skin disinfectant</td><td>Jinan Xinyongtai Shiye Co., Ltd</td><td>http://www.sdxyt.cn/zh/products_detail.asp?id=23</td><td></td></tr><tr><td>Sterile Irrigator for Single Use</td><td>Shandong Weigao Group Medical Polymer CO.,Ltd</td><td>https://weigaogroup.com/photo/show-114.aspx</td><td></td></tr><tr><td>Sterile medical sponge for Single Use</td><td>Beijing Kang&#039;an Kelin Technology Co., Ltd</td><td>SS-96A</td><td></td></tr><tr><td>Tobramycin Eye Drops</td><td>Alcon-Couvreur</td><td>H20150119</td><td></td></tr><tr><td>Transparent Film Dressing Frame Style</td><td>Minnesota Mining and Manufacturing</td><td>1624WCN</td><td></td></tr><tr><td>VisuMax femtosecond laser system</td><td>Carl Zeiss Meditec, Inc., Dublin, CA</td><td>20183241728</td><td></td></tr></tbody></table>

correction of presbyopia by monocular bi-aspheric ablation profile

<meta charset="utf8"></head><body>作者聚焦:老花眼屈光手术矫正的进展和探索术后视力

通过单眼双非球面消融剖面矫正老花眼

The study aims to evaluate visual acuity and objective visual quality before and after the monocular bi-aspheric ablation profile for correction of ...

correction-of-presbyopia-by-monocular-bi-aspheric-ablation-profile

Research

JoVE Journal

Medicine

Correction of Presbyopia by Monocular Bi-Aspheric Ablation Profile

329 次观看.  Shandong University of Traditional Chinese Medicine. 我们致力于老花眼的屈光手术矫正，探索其术后视力效应和冠状位形态，以期为该技术的临床应用提供可靠的参考价值。本文应用的矫正技术改善了以往多焦点矫正后远视力不足、适应困难的现象，更适合对远视力要求较高的患者。未来，我们将更加注重几种不同矫正方法的比较研究，尝试为不同情况下的老花眼患者提供最佳的治疗方案。

视频: 作者聚焦:老花眼屈光手术矫正的进展和探索术后视力

Corneal Confocal Microscopy: A Novel Non-invasive Technique to Quantify Small Fibre Pathology in Peripheral Neuropathies

The accurate quantification of peripheral neuropathy is important to define at risk patients, anticipate deterioration, and assess new therapies. Conventional methods assess neurological deficits and electrophysiology and quantitative sensory testing quantifies functional alterations to detect neuropathy. However, the earliest damage appears to be to the small fibres and yet these tests primarily assess large fibre dysfunction and have a limited ability to demonstrate regeneration and repair. The only techniques which allow a direct examination of unmyelinated nerve fibre damage and repair are sural nerve biopsy with electron microscopy and skin-punch biopsy. However, both are invasive procedures and require lengthy laboratory procedures and considerable expertise. Corneal Confocal microscopy is a non-invasive clinical technique which provides in-vivo imaging of corneal nerve fibres. We have demonstrated early nerve damage, which precedes loss of intraepidermal nerve fibres in skin biopsies together with stratification of neuropathic severity and repair following pancreas transplantation in diabetic patients. We have also demonstrated nerve damage in idiopathic small fibre neuropathy and Fabry's disease.

Corneal Confocal microscopy is a non-invasive clinical technique which may be used to quantify C fibre damage to diagnose and stratify patients with increasing neuropathic severity.

角膜共聚焦显微镜：一种新型的非侵入性技术来量化小纤维病变周围神经病变

The accurate quantification of peripheral neuropathy is important to define at risk patients, anticipate deterioration, and assess new therapies. ...

科研

医学

Thermal Ablation for the Treatment of Abdominal Tumors

Percutaneous thermal ablation is an emerging treatment option for many tumors of the abdomen not amenable to conventional treatments. During a thermal ablation procedure, a thin applicator is guided into the target tumor under imaging guidance. Energy is then applied to the tissue until temperatures rise to cytotoxic levels (50-60 &deg;C). Various energy sources are available to heat biological tissues, including radiofrequency (RF) electrical current, microwaves, laser light and ultrasonic waves. Of these, RF and microwave ablation are most commonly used worldwide.
During RF ablation, alternating electrical current (~500 kHz) produces resistive heating around the interstitial electrode. Skin surface electrodes (ground pads) are used to complete the electrical circuit. RF ablation has been in use for nearly 20 years, with good results for local tumor control, extended survival and low complication rates1,2. Recent studies suggest RF ablation may be a first-line treatment option for small hepatocellular carcinoma and renal-cell carcinoma3-5. However, RF heating is hampered by local blood flow and high electrical impedance tissues (eg, lung, bone, desiccated or charred tissue)6,7. Microwaves may alleviate some of these problems by producing faster, volumetric heating8-10. To create larger or conformal ablations, multiple microwave antennas can be used simultaneously while RF electrodes require sequential operation, which limits their efficiency. Early experiences with microwave systems suggest efficacy and safety similar to, or better than RF devices11-13.
Alternatively, cryoablation freezes the target tissues to lethal levels (-20 to -40 &deg;C). Percutaneous cryoablation has been shown to be effective against RCC and many metastatic tumors, particularly colorectal cancer, in the liver14-16. Cryoablation may also be associated with less post-procedure pain and faster recovery for some indications17. Cryoablation is often contraindicated for primary liver cancer due to underlying coagulopathy and associated bleeding risks frequently seen in cirrhotic patients. In addition, sudden release of tumor cellular contents when the frozen tissue thaws can lead to a potentially serious condition known as cryoshock 16.
Thermal tumor ablation can be performed at open surgery, laparoscopy or using a percutaneous approach. When performed percutaneously, the ablation procedure relies on imaging for diagnosis, planning, applicator guidance, treatment monitoring and follow-up. Ultrasound is the most popular modality for guidance and treatment monitoring worldwide, but computed tomography (CT) and magnetic resonance imaging (MRI) are commonly used as well. Contrast-enhanced CT or MRI are typically employed for diagnosis and follow-up imaging.

A thermal tumor ablation procedure is described. The entire procedure is detailed, including pretreatment planning and imaging studies, anesthesia, adjuvant techniques to facilitate a percutaneous approach, imaging guidance of the ablation device to the tumor, thermal treatment, post-treatment care and follow-up.

热消融治疗腹部肿瘤

Percutaneous thermal ablation is an emerging treatment option for many tumors of the abdomen not amenable to conventional treatments. During a thermal ...

Ultrasound Cyclo Plasty in Eyes with Glaucoma

Glaucoma is a chronic disease caused by the progressive degeneration of the optical nerve fibers, resulting in decreased visual field that can lead to severe visual impairment, and eventually blindness. This manuscript describes a simple, surgeon-friendly, non-incisional technique, named Ultrasound Cyclo Plasty (UCP), for reducing intraocular pressure (IOP) in glaucoma patients. The technique determines a selective coagulation necrosis of the ciliary body; in addition, the stimulation of supra-choroidal and trans-scleral portions of the uveo-scleral outflow pathway has been recently proposed. UCP shows several technical improvements in ultrasound technology compared to previous techniques, providing more precise focusing on the target zone. The procedure is performed in the operating room under peribulbar anesthesia. Briefly, the coupling cone is put in contact with the eye and the ring probe, that contains six piezoelectric transducers which produce the ultrasound beams, is inserted inside it. Their proper centering over the ocular surface represents a crucial step for the correct targeting of the ciliary body. Sterile balanced salt solution is used to fill the empty spaces to ensure ultrasound acoustic propagation. Surgical treatment consists in the sequential automatic activation of each of the six transducers, for a total duration of less than 3 min. The patient leaves the hospital 1 h after the procedure with the treated eye patched. In the present study, 10 patients with open-angle glaucoma were followed-up during at least 12 months after the procedure. IOP was reduced at each interval compared to pre-operative, as well as the number of hypotensive medications. Twenty percent of patients did not respond to the treatment, and needed subsequent surgery to better control IOP. Treatment tolerability was good, with no cases of hypotony or phthisis. The UCP procedure is simpler, faster, safer, and less invasive than traditional cyclodestructive procedures with similar results in reducing IOP.

Glaucoma is a chronic disease with progressive degeneration of optic nerve fibers resulting in decreased visual field. Elevated intraocular pressure is considered the most important and the only treatable risk factor. This manuscript describes a simple, surgeon-friendly, non-incisional technique, named Ultrasound Cyclo Plasty, for reducing intraocular pressure in glaucoma patients.

青光眼眼中的超声环成形术

Glaucoma is a chronic disease caused by the progressive degeneration of the optical nerve fibers, resulting in decreased visual field that can lead to ...

行为学

Stereoacuity Improvement using Random-Dot Video Games

Conventional amblyopia therapy involves occlusion or penalization of the dominant eye, though these methods enhance stereoscopic visual acuity in fewer than 30% of cases. To improve these results, we propose a treatment in the form of a video game, using random-dot stimuli and perceptual learning techniques to stimulate stereoacuity. The protocol is defined for stereo-deficient patients between 7-14 years of age who have already received treatment for amblyopia and have a monocular best corrected distance visual acuity of at least 0.1 logMAR. Patients are required to complete a perceptual learning program at home using the video game. While compliance is stored automatically in the cloud, periodic optometry center visits are used to track patient evolution and adjust the game&#39;s stereoscopic demand until the smallest detectable disparity is achieved. The protocol has proved to be successful, and effectiveness is gauged in terms of a two-level gain on a random stereoacuity test (global stereoacuity or cyclopean stereoacuity reference test). Moreover, the random-dot stimuli learning transfers to medial lateral stereoscopic acuity according to a Wirt Circles test, in which success criteria is a final stereoacuity of over 140&#34;, and the attained enhancement corresponds to no less than two levels of stereoscopic acuity. Six months later, a random-dot stereoacuity test recorded no reduction in the stereoacuity that was achieved.

Presented here is a protocol to improve stereoacuity using gamified perceptual learning software based on random-dot stimuli. Patients are stereo-deficient subjects without strabismus. The protocol combines optometry center visits with home exercises using software. Compliance and stereoacuity evolution are stored in the cloud.

使用随机点视频游戏提高立体性

Conventional amblyopia therapy involves occlusion or penalization of the dominant eye, though these methods enhance stereoscopic visual acuity in fewer ...

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model

Myopic individuals, especially those with severe myopia, are at higher-than-normal risk of cataract, glaucoma, retinal detachment and chorioretinal abnormalities. In addition, pathological myopia is a common irreversible cause of visual impairment and blindness1-3. Our study demonstrates the effect of scleral crosslinking using riboflavin and ultraviolet-A radiation on the development of axial myopia in a rabbit model. The axial length of the eyeball was measured by A-scan ultrasound in New Zealand white rabbits aged 13 days (male and female). The eye then underwent 360&#176; conjunctival peritomy with scleral crosslinking, followed by tarsorrhaphy. Axial elongation was induced in 13 day-old New Zealand rabbits by suturing their right eye eyelids (tarsorrhaphy). The eyes were divided into quadrants, and every quadrant had two scleral irradiation zones, each with an area of 0.2 cm&#178; and a radius of 4 mm. Crosslinking was performed by dropping 0.1% dextran-free riboflavin-5-phosphate onto the irradiation zones 20 sec before ultraviolet-A irradiation and every 20 sec during the 200 sec irradiation time. UVA radiation (370 nm) was applied perpendicular to the sclera at 57 mW/cm&#178; (total UVA light dose, 57 J/cm&#178;). Tarsorrhaphies were removed on day 55, followed by repeated axial length measurements. This study demonstrates that scleral crosslinking with riboflavin and ultraviolet-A radiation effectively prevents occlusion-induced axial elongation in a rabbit model.

We demonstrate the effect of scleral crosslinking with riboflavin and UVA on an axial elongation rabbit eye. Axial elongation was induced in 13 day-old New Zealand rabbits (male and female) by suturing their right eye eyelids (tarsorrhaphy).

巩膜交联兔模型使用核黄素和紫外辐射的轴性近视防治

Myopic individuals, especially those with severe myopia, are at higher-than-normal risk of cataract, glaucoma, retinal detachment and chorioretinal ...

Iris Fixation via External Pentagram Suturing

Extensive anterior synechia of the iris can result in the gradual disappearance of the anterior chamber. It is one of the most common outcomes of both oculopathy and complicated post anterior segment surgery. This can impact visual function and lead to bullous keratopathy, making it one of the most complex clinical problems. Conventional anterior chamber plasty will partially create the anterior chamber, but the anterior chamber disappears again in some cases. The main reasons are: (1) the iris lens diaphragm is loose with atrophied and tension-free iris so that the aqueous humor circulation will push and squeeze the iris forward; (2) the effect of "roller" formed in the process of inflammation or restoration will change the iris structure from peripheral anterior synechia (PAS) to extensive anterior synechia again; (3) the fibration will result in synechia from iris to the cornea. In such cases, corneal endothelium deficiency can't stop the aqueous humor from entering the cornea. This results in persistent corneal edema post-conventional anterior chamber plasty, resulting in progressive rubbing and lachrymation. Therefore, anterior chamber plasty is not the first choice for patients without surgical indications of Descemet's stripping automated endothelial keratoplasty (DSAEK). However, this can be performed in patients with surgical indications who plan to receive DSAEK. A unique method of iris fixation via external pentagram suturing anterior chamber plasty (PSACP) is described here. The present technique is also compared with the conventional anterior chamber plasty. PSACP and DSAEK might be an effective way to cure the bullous keratopathy with extensive anterior synechia of the iris and disappeared anterior chamber.

Iris Fixation via External Pentagram Suturing

The present protocol describes how a 10-0 polypropylene suture crosses the anterior surface of the iris, forming a pentagram to prevent both iris and pupil from moving toward the cornea. This can be combined with subsequent keratoplasty to cure bullous keratopathy with extensive anterior synechia of the iris.

虹膜通过外部五角星缝合固定

Extensive anterior synechia of the iris can result in the gradual disappearance of the anterior chamber. It is one of the most common outcomes of both ...

Binocular Dynamic Visual Acuity in Eyeglass-Corrected Myopic Patients

Current clinical visual assessment mainly focuses on static vision. However, static vision may not sufficiently reflect real-life visual function as moving optotypes are frequently observed daily. Dynamic visual acuity (DVA) might reflect real-life situations better, especially when objects are moving at high speeds. Myopia impacts static uncorrected distance visual acuity, conveniently corrected with eyeglasses. However, due to peripheral defocus and prism effects, eyeglass correction might affect DVA. The present research demonstrates a standard method to examine eyeglass-corrected DVA in myopia patients, and aimed to explore the influence of eyeglass correction on DVA. 
Initially, standard subjective refraction was performed to provide the eyeglass prescription to correct the refractive error. Then, binocular distance vision-corrected DVA was examined using the object-moving DVA protocol. Software was designed to display the moving optotypes according to the preset velocity and size on a screen. The optotype was the standard logarithmic visual chart letter E and moves from the middle of the left to the right side horizontally during the test. Moving optotypes with randomized opening direction for each size are displayed. The subjects were required to identify the opening direction of the optotype, and the DVA is defined as the minimum optotype that subjects could recognize, calculated according to the algorithm of logarithmic visual acuity.
Then, the method was applied in 181 young myopic subjects with eyeglass-corrected-to-normal static visual acuity. Dominant eye, cycloplegic subjective refraction (sphere and cylinder), accommodation function (negative and positive relative accommodation, binocular cross-cylinder), and binocular DVA at 40 and 80 degrees per second (dps) were examined. The results showed that with increasing age, DVA first increased and then decreased. When myopia was fully corrected with eyeglasses, a worse binocular DVA was associated with more significant myopic refractive error. There was no correlation between the dominant eye, accommodation function, and binocular DVA.

The present research demonstrates a method to accurately examine dynamic visual acuity (DVA) in myopic subjects with eyeglass correction. Further analysis indicated that the closer the refraction state to emmetropia, the better the eyeglass-corrected binocular DVA is at both 40 and 80 degrees per second.

眼镜矫正近视患者的双眼动态视力

Current clinical visual assessment mainly focuses on static vision. However, static vision may not sufficiently reflect real-life visual function as ...

在白内障手术中通过 IOL 旋转预防后囊膜混浊

Rotating the Intraocular Lens to Prevent Posterior Capsular Opacification in Cataract Surgeries

Posterior capsule opacification (PCO) is a common postoperative complication of extracapsular cataract surgery, which is caused by the proliferation and migration of lens epithelial cells and can affect long-term visual outcomes significantly. The most effective treatment for PCO is neodymium-doped yttrium aluminum garnet (Nd:YAG) laser capsulotomy; however, this treatment is associated with posterior segment complication and can break the stability of capsular bag, affecting the position and function of trifocal or toric intraocular lenses (IOLs). Advances in surgical procedures, IOL design, and pharmacy have reduced the rate of PCO in recent years, concentrating on the inhibition of proliferative lens epithelial cells (LECs). This protocol aimed to clear LECs more thoroughly during phacoemulsification and IOL implantation. The first several steps, including clear corneal incision, continuous circular capsulorhexis, hydrodissection, hydrodelineation, and phacoemulsification, were completed as conventional procedures. After placing the IOL into the capsular bag, rotation of the IOL by at least 360&#176; was performed using an irrigation/aspiration tip or a hook, with slight stress on the posterior capsule. Some residuals occurred in the originally transparent capsular bag after rotation of the IOLs. Then, these materials and the viscoelastic were cleared completely using an irrigation/aspiration system. A clear posterior capsule was observed after the surgery in patients undergoing this method. This method of rotating IOLs is a simple, effective, and safe way to prevent PCO by clearing residual LECs and can be carried out without extra tools or skills.

作者聚焦：增强白内障手术的视觉效果：一种通过 IOL 旋转防止后囊膜混浊的新技术 

The present protocol describes removing residual epithelial cells by rotating the intraocular lens in extracapsular cataract surgery without extra tools for preventing posterior capsular opacification.

在白内障手术中旋转人工晶状体以防止后囊混浊

Posterior capsule opacification (PCO) is a common postoperative complication of extracapsular cataract surgery, which is caused by the proliferation and ...

通过单眼双非球面消融剖面矫正老花眼

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在白内障手术中旋转人工晶状体以防止后囊混浊