Shandong Medical and Health Science and Technology Development Plan Project (202207020806)

The following protocol was reviewed and approved by the Ethics Committee of the Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine (Grant No. HEC-KS-2020002KY), and was strictly adhered to the Declaration of Helsinki. All patients signed an informed consent form.
1. Patient selection
NOTE: 20 patients (38 eyes) with presbyopia treated by excimer laser monocular multifocal bi-aspheric ablation were admitted to the Department...

Excimer Laser Multifocal Double Aspheric Ablation for Presbyopia Correction

<ol>
	<li>Wolffsohn, J. S., Davies, L. N. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Presbyopia:+Effectiveness+of+correction+strategies.">Presbyopia: Effectiveness of correction strategies.</a> Prog Retin Eye Res. 68, 124-143 (2019).</li><li>Frick, K. D., Joy, S. M., Wilson, D. A., Naidoo, K. S., Holden, B. A. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=The+global+burden+of+potential+productivity+loss+from+uncorrected+presbyopia.">The global burden of potential productivity loss from uncorrected presbyopia.</a> Ophthalmology. 122 (8), 1706-1710 (2015).</li><li>Nanavaty, M. A., Daya, S. M. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Refractive+lens+exchange+versus+phakic+intraocular+lenses.">Refractive lens exchange versus phakic intraocular lenses.</a> Curr Opin Ophthalmol. 23 (1), 54-61 (2012).</li><li>Soler Tom&#225;s, J. R., Fuentes-P&#225;ez, G., Burillo, S. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Symmetrical+versus+asymmetrical+PresbyLASIK:+Results+after+18+months+and+patient+satisfaction.">Symmetrical versus asymmetrical PresbyLASIK: Results after 18 months and patient satisfaction.</a> Cornea. 34 (6), 651-657 (2015).</li><li>Shetty, R., Brar, S., Sharma, M., Dadachanji, Z., Lalgudi, V. G. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=PresbyLASIK:+A+review+of+PresbyMAX,+Supracor,+and+laser+blended+vision:+Principles,+planning,+and+outcomes.">PresbyLASIK: A review of PresbyMAX, Supracor, and laser blended vision: Principles, planning, and outcomes.</a> Indian J Ophthalmol. 68 (12), 2723-2731 (2020).</li><li>Pinelli, R., Ortiz, D., Simonetto, A., Bacchi, C., Sala, E., Ali&#243;, J. L. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Correction+of+presbyopia+in+hyperopia+with+a+center-distance,+paracentral-near+technique+using+the+Technolas+217z+platform.">Correction of presbyopia in hyperopia with a center-distance, paracentral-near technique using the Technolas 217z platform.</a> J Refract Surg. 24 (5), 494-500 (2008).</li><li>Ali&#243;, J. L., Chaubard, J. J., Caliz, A., Sala, E., Patel, S. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Correction+of+presbyopia+by+technovision+central+multifocal+LASIK+(presbyLASIK).">Correction of presbyopia by technovision central multifocal LASIK (presbyLASIK).</a> J Refract Surg. 22 (5), 453-460 (2006).</li><li>Vargas-Fragoso, V., Ali&#243;, J. L. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Corneal+compensation+of+presbyopia:+PresbyLASIK:+An+updated+review.">Corneal compensation of presbyopia: PresbyLASIK: An updated review.</a> Eye Vis (Lond). 4, 11 (2017).</li><li>Pallikaris, I. G., Panagopoulou, S. I. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=PresbyLASIK+approach+for+the+correction+of+presbyopia.">PresbyLASIK approach for the correction of presbyopia.</a> Curr Opin Ophthalmol. 26 (4), 265-272 (2015).</li><li>Ryu, S., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Presbyopia+correction+using+the+monocular+bi-aspheric+ablation+profile+in+myopic+eyes.">Presbyopia correction using the monocular bi-aspheric ablation profile in myopic eyes.</a> J Cataract Refract Surg. 49 (1), 69-75 (2023).</li><li>Fu, D., Zhao, J., Zeng, L., Zhou, X. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=One+year+outcome+and+satisfaction+of+presbyopia+correction+using+the+PresbyMAX&#174;+monocular+ablation+profile.">One year outcome and satisfaction of presbyopia correction using the PresbyMAX&#174; monocular ablation profile.</a> Front Med (Lausanne). 7, 589275 (2020).</li><li>Fu, D., Zhao, J., Zhou, X. T. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Objective+optical+quality+and+visual+outcomes+after+the+PresbyMAX+monocular+ablation+profile.">Objective optical quality and visual outcomes after the PresbyMAX monocular ablation profile.</a> Int J Ophthalmol. 13 (7), 1060-1065 (2020).</li><li>Braun, E. H., Lee, J., Steinert, R. F. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Monovision+in+LASIK.">Monovision in LASIK.</a> Ophthalmology. 115 (7), 1196-1202 (2008).</li><li>Kohnen, T., B&#246;hm, M., Herzog, M., Hemkeppler, E., Petermann, K., Lwowski, C. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Near+visual+acuity+and+patient-reported+outcomes+in+presbyopic+patients+after+bilateral+multifocal+aspheric+laser+in+situ+keratomileusis+excimer+laser+surgery.">Near visual acuity and patient-reported outcomes in presbyopic patients after bilateral multifocal aspheric laser in situ keratomileusis excimer laser surgery.</a> J Cataract Refract Surg. 46 (7), 944-952 (2020).</li><li>Uthoff, D., P&#246;lzl, M., Hepper, D., Holland, D. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=A+new+method+of+cornea+modulation+with+excimer+laser+for+simultaneous+correction+of+presbyopia+and+ametropia.">A new method of cornea modulation with excimer laser for simultaneous correction of presbyopia and ametropia.</a> Graefes Arch Clin Exp Ophthalmol. 250 (11), 1649-1661 (2012).</li><li>Baudu, P., Penin, F., Mosquera Arba, S. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Uncorrected+binocular+performance+after+biaspheric+ablation+profile+for+presbyopic+corneal+treatment+using+AMARIS+with+the+PresbyMAX+module.">Uncorrected binocular performance after biaspheric ablation profile for presbyopic corneal treatment using AMARIS with the PresbyMAX module.</a> Am J Ophthalmol. 155 (4), 636-647 (2013).</li><li>Luger, M. H., McAlinden, C., Buckhurst, P. J., Wolffsohn, J. S., Verma, S., Arba-Mosquera, S. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Presbyopic+LASIK+using+hybrid+bi-aspheric+micro-monovision+ablation+profile+for+presbyopic+corneal+treatments.">Presbyopic LASIK using hybrid bi-aspheric micro-monovision ablation profile for presbyopic corneal treatments.</a> Am J Ophthalmol. 160 (3), 493-505 (2015).</li><li>Luger, M. H., Ewering, T., Arba-Mosquera, S. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=One-year+experience+in+presbyopia+correction+with+biaspheric+multifocal+central+presbyopia+laser+in+situ+keratomileusis.">One-year experience in presbyopia correction with biaspheric multifocal central presbyopia laser in situ keratomileusis.</a> Cornea. 32 (5), 644-652 (2013).</li><li>Chan, T. C., Kwok, P. S., Jhanji, V., Woo, V. C., Ng, A. L. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Presbyopic+correction+using+monocular+bi-aspheric+ablation+profile+(PresbyMAX)+in+hyperopic+eyes:+1-year+outcomes.">Presbyopic correction using monocular bi-aspheric ablation profile (PresbyMAX) in hyperopic eyes: 1-year outcomes.</a> J Refract Surg. 33 (1), 37-43 (2017).</li><li>El Danasoury, A. M., Gamaly, T. O., Hantera, M. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Multizone+LASIK+with+peripheral+near+zone+for+correction+of+presbyopia+in+myopic+and+hyperopic+eyes:+1-year+results.">Multizone LASIK with peripheral near zone for correction of presbyopia in myopic and hyperopic eyes: 1-year results.</a> J Refract Surg. 25 (3), 296-305 (2009).</li><li>Yebra-Pimentel, E., Gonz&#225;lez-J&#233;ijome, J. M., Cervi&#241;o, A., Gir&#225;ldez, M. J., Gonz&#225;lez-P&#233;rez, J., Parafita, M. A. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Corneal+asphericity+in+a+young+adult+population.+Clinical+implications.">Corneal asphericity in a young adult population. Clinical implications.</a> Arch Soc Esp Oftalmol. 79 (8), 385-392 (2004).</li><li>Calossi, A. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Corneal+asphericity+and+spherical+aberration.">Corneal asphericity and spherical aberration.</a> J Refract Surg. 23 (5), 505-514 (2007).</li></ol>

All authors have nothing to disclose.

Currently, there are limited effective methods for restoring ocular accommodation, making presbyopia a prominent area of research in refractive surgery. The bi-aspheric ablation profile, a widely recognized clinical modality for presbyopia correction, has shown favorable safety and efficacy with satisfactory postoperative outcomes15,16,17. However, there is a paucity of studies focusing on the monocular mode. In this study, we p...

Presbyopia is an age-related reduction in amplitude of accommodation leading to loss of near vision due to the loss of function of the lens and ciliary muscle1. The global population of presbyopes is projected to exceed 2 billion by 2030, with uncorrected and undercorrected presbyopia affecting socio-economic development2. Correction of presbyopia includes lens correction, surgical approaches, and medication. Corneal surgery is one of the main forms of corneal surgery to correct presbyopia because of its less invasive nature, fewer complications, and faster recovery3.
Ruiz introduced Presby laser-assisted in situ keratomileusis (LASIK) in 1996, which ablates the cornea into a multifocal pattern and increases the negative SA to achieve simultaneous near and distance vision4,5. Depending on the proximity area, Presby LASIK can be categorized into peripheral model6 (peripheral area for near vision and central area for distance vision) and central model7(peripheral area for distance vision and central area for near vision)8,9. The monocular bi-aspheric ablation profile is a hybrid Presby LASIK that combines the advantages of multiple programs, including micro-monocular vision, bi-aspheric, and multifocal. The dominant eye is completely corrected for distance vision, the central zone of the non-dominant eye retains approximately -0.89D of refraction for near vision, the peripheral cornea is ablated for distance vision, and the range of near addition (ADD) is between +1.25D to 2.50D, and aspheric cutting is used in both the central and peripheral zones10,11.
Compared with the previous monovision LASIK, the multifocal morphology of the non-dominant eye after the monocular bi-aspheric ablation profile reduces the anisometropia between the two eyes. The negative increase of SA introduces the depth of focus, which can better improve near vision and, at the same time, improve the intermediate vision, reduce the impact on stereopsis, and improve the patient&#39;s acceptance and satisfaction11,12,13. The monocular mode will lead to complete correction of the dominant eye, which can achieve the fastest postoperative clear full vision, reduce the risk of UDVA decline, and is more suitable for patients with presbyopia who have the same requirements for UDVA and UIVA, while other algorithms are multifocal in both eyes, which need more time for adaptation after surgery and have the risk of UDVA decline14,15,16. This article describes the detailed surgical steps of excimer laser multifocal double aspheric ablation mode as a surgical guide.

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correction of presbyopia by monocular bi-aspheric ablation profile

The study aims to evaluate visual acuity and objective visual quality before and after the monocular bi-aspheric ablation profile for correction of presbyopia surgery. This prospective self-control study included 20 cases and 38 eyes of patients who underwent monocular bi-aspheric ablation profile correction of myopia with presbyopia at the Eye Hospital of Shandong University of Traditional Chinese Medicine from January 2023 to January 2024. These patients were selected for observation, and each patient's preoperative and postoperative uncorrected distance visual acuity (UDVA), uncorrected near visual acuity (UNVA), corrected distance visual acuity (CDVA), spherical aberration (SA) (within 6 mm), horizontal and vertical coma (within 6 mm), and corneal aspheric index (Q-value) (within 6 mm) were evaluated. Statistical data analysis was performed at different time points before and after the operation. There were statistically significant differences in UDVA between dominant and non-dominant eyes before and after surgery (Z = -3.784, p &lt; 0.001; Z = -3.817, p &lt; 0.001). Post-operatively, 90% of the non-dominant eyes achieved UNVA of J1 and above, and 95% of the bilateral eyes achieved UNVA of J1 and above. Significant differences were found in the SA of the dominant eyes, which showed a positive increase (Z= -3.784, p &lt; 0.001); however, compared with the dominant eye, the SA of the non-dominant eye was negatively increased, but the difference was not statistically significant (p = 0.08). There was a significant difference in the vertical coma of the dominant eye before and after the operation, but there was no significant difference in non-dominant eyes. There was no significant difference in the change of binocular horizontal coma before and after the operation. There were significant changes in the Q value of both eyes before and after the operation (Z = -3.923, p &lt; 0.001; Z = -3.51, p &lt; 0.001). After the monocular bi-aspheric ablation profile, the cornea of the non-dominant eye showed a prolate shape, negative SA increased, and the UDVA and UNVA improved after the operation.

Author Spotlight: Advancements in Refractive Surgical Correction for Presbyopia and Exploring Postoperative Visual Acuity

Correction of Presbyopia by Monocular Bi-Aspheric Ablation Profile

We are committed to a refractive surgical correction of presbyopia and exploring its postoperative visual acuity effect and coronal morphology in order to provide a reliable reference value for the clinical application of this technology. The correction technique applied in this paper has improved the phenomenon of insufficient distance vision and difficulty in adaptation after multifocal correction in the past, and is more suitable for patients with high requirements for distance vision. In the future, we will pay more attention to the comparative research of several different correction method and try to provide the best treatment plan for patients with presbyopia in different conditions.

A total of 20 patients who underwent the monocular bi-aspheric ablation profile for correction of presbyopia were analyzed in this study. The preoperative age of the patients was 47 (&#177; 3.36) years, and the preoperative spherical equivalent (SE) of the dominant and non-dominant eyes were -4.47 D (&#177; 2.16) D and -4.34 D (&#177;2.09 D), respectively. All surgeries were completed with no postoperative complications.
Visual acuity results 
There was no significant dif...

This article provides a step-by-step guide to correcting presbyopia with a monocular bi-aspheric ablation profile.

The study aims to evaluate visual acuity and objective visual quality before and after the monocular bi-aspheric ablation profile for correction of ...

correction-of-presbyopia-by-monocular-bi-aspheric-ablation-profile

Research

JoVE Journal

Medicine

211 조회수.  Shandong University of Traditional Chinese Medicine. 우리는 노안의 굴절 수술 교정에 전념하고 이 기술의 임상 적용을 위한 신뢰할 수 있는 참조 값을 제공하기 위해 수술 후 시력 효과와 관상 형태를 탐구하고 있습니다. 본 논문에 적용된 보정기법은 과거 다초점 보정 후 원거리시력이 부족하고 적응이 어려워지는 현상을 개선하였으며, 원거리시력에 대한 요구사항이 높은 환자에게 더욱 적합하다. ?...