Isabelle Broutin

Crystal structures of the SH2 domain of Grb2: highlight on the binding of a new high-affinity inhibitor.

The PIR domain of Grb14 is an intrinsically unstructured protein: implication in insulin signaling.

Changes in structural dynamics of the Grb2 adaptor protein upon binding of phosphotyrosine ligand to its SH2 domain.

Solution NMR structure of the SH3 domain of human nephrocystin and analysis of a mutation-causing juvenile nephronophthisis.

Expression, purification, crystallization and preliminary X-ray studies of the outer membrane efflux proteins OprM and OprN from Pseudomonas aeruginosa.

High affinity Grb2-SH3 domain ligand incorporating Cbeta-substituted prolines in a Sos-derived decapeptide.

Structural and thermodynamic bases for the design of pure prolactin receptor antagonists: X-ray structure of Del1-9-G129R-hPRL.

A non-canonical Grb2-PLC-gamma1-Sos cascade triggered by lipovitellin 1, an apolipoprotein B homologue.

Enzyme structural plasticity and the emergence of broad-spectrum antibiotic resistance.

Molecular determinants of Grb14-mediated inhibition of insulin signaling.

NKX2-1 mutations leading to surfactant protein promoter dysregulation cause interstitial lung disease in "Brain-Lung-Thyroid Syndrome".

Crystal structure of an affinity-matured prolactin complexed to its dimerized receptor reveals the topology of hormone binding site 2.

Structural and dynamical insights into the opening mechanism of P. aeruginosa OprM channel.

Structural characterization of the stem-stem dimerization interface between prolactin receptor chains complexed with the natural hormone.

Mutations in INF2 are a major cause of autosomal dominant focal segmental glomerulosclerosis.

Novel NOBOX loss-of-function mutations account for 6.2% of cases in a large primary ovarian insufficiency cohort.

INF2 mutations in Charcot-Marie-Tooth disease with glomerulopathy.

Targeting the proangiogenic VEGF-VEGFR protein-protein interface with drug-like compounds by in silico and in vitro screening.

Activity monitoring of functional OprM using a biomimetic microfluidic device.

Photo-induced proton gradients for the in vitro investigation of bacterial efflux pumps.

Stoichiometry of the MexA-OprM binding, as investigated by blue native gel electrophoresis.

Unusual binding of Grb2 protein to a bivalent polyproline-ligand immobilized on a SPR sensor: intermolecular bivalent binding.

Hoechst likes to play hide and seek...use it with caution!

Contribution of asparagine 346 residue to the carbapenemase activity of CMY-2 β-lactamase.

Multiple mutations lead to MexXY-OprM-dependent aminoglycoside resistance in clinical strains of Pseudomonas aeruginosa.