Frank Edenhofer

Ability of the hydrophobic FGF and basic TAT peptides to promote cellular uptake of recombinant Cre recombinase: a tool for efficient genetic engineering of mammalian genomes.

Efficient in vitro and in vivo excision of floxed sequences with a high-capacity adenoviral vector expressing Cre recombinase.

mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells.

Site-specific recombination in human embryonic stem cells induced by cell-permeant Cre recombinase.

Merging fields: stem cells in neurogenesis, transplantation, and disease modeling.

Cargo-dependent mode of uptake and bioavailability of TAT-containing proteins and peptides in living cells.

Stage-specific conditional mutagenesis in mouse embryonic stem cell-derived neural cells and postmitotic neurons by direct delivery of biologically active Cre recombinase.

Peroxisome proliferator-activated receptor gamma control of dendritic cell function contributes to development of CD4+ T cell anergy.

Enhanced purification of cell-permeant Cre and germline transmission after transduction into mouse embryonic stem cells.

Stem cell engineering using transducible Cre recombinase.

Runx genes are direct targets of Scl/Tal1 in the yolk sac and fetal liver.

Generation of transducible versions of transcription factors Oct4 and Sox2.

Protein transduction revisited: novel insights into the mechanism underlying intracellular delivery of proteins.

Increased antigen cross-presentation but impaired cross-priming after activation of peroxisome proliferator-activated receptor gamma is mediated by up-regulation of B7H1.

Deciphering the stem cell machinery as a basis for understanding the molecular mechanism underlying reprogramming.

Novel reporter mouse reveals constitutive and inflammatory expression of IFN-beta in vivo.

Dre recombinase, like Cre, is a highly efficient site-specific recombinase in E. coli, mammalian cells and mice.

Monodispersity of recombinant Cre recombinase correlates with its effectiveness in vivo.

Inhibition of notch signaling in human embryonic stem cell-derived neural stem cells delays G1/S phase transition and accelerates neuronal differentiation in vitro and in vivo.

Engineering cell-permeant FLP recombinase for tightly controlled inducible and reversible overexpression in embryonic stem cells.

Transcription factor-based modulation of neural stem cell differentiation using direct protein transduction.

Peroxisome proliferator-activated receptor (PPAR)gamma can inhibit chronic renal allograft damage.

Sox2 is essential for formation of trophectoderm in the preimplantation embryo.

Genetic engineering of mammalian cells by direct delivery of FLP recombinase protein.

Exploring refined conditions for reprogramming cells by recombinant Oct4 protein.

Non-Genetic Modulation of Notch Activity by Artificial Delivery of Notch Intracellular Domain into Neural Stem Cells.

Direct conversion of fibroblasts into stably expandable neural stem cells.

Cellular reprogramming employing recombinant sox2 protein.

MicroRNAs are indispensable for reprogramming mouse embryonic fibroblasts into induced stem cell-like cells.

A thermoresponsive and chemically defined hydrogel for long-term culture of human embryonic stem cells.

Automated selection and harvesting of pluripotent stem cell colonies.

A LewisX glycoprotein screen identifies the low density lipoprotein receptor-related protein 1 (LRP1) as a modulator of oligodendrogenesis in mice.

Cell-permeant recombinant Nanog protein promotes pluripotency by inhibiting endodermal specification.

Excision of viral reprogramming cassettes by Cre protein transduction enables rapid, robust and efficient derivation of transgene-free human induced pluripotent stem cells.

Robust Generation of Cardiomyocytes from Human iPS Cells Requires Precise Modulation of BMP and WNT Signaling.

Characterization of a novel cell penetrating peptide derived from human Oct4.

Quantification of cell fusion events human breast cancer cells and breast epithelial cells using a Cre-LoxP-based double fluorescence reporter system.