Mark A. Behlke

Structure-function relationships of shared-stem and conventional molecular beacons.

Hybridization of 2'-O-methyl and 2'-deoxy molecular beacons to RNA and DNA targets.

Hybridization kinetics and thermodynamics of molecular beacons.

Hybridization of 2'-O-methyl and 2'-deoxy molecular beacons to RNA and DNA targets.

Spectroscopic features of dual fluorescence/luminescence resonance energy-transfer molecular beacons.

Thermodynamic treatment of oligonucleotide duplex-simplex equilibria.

Effects of sodium ions on DNA duplex oligomers: improved predictions of melting temperatures.

Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy.

Effects of fluorescent dyes, quenchers, and dangling ends on DNA duplex stability.

A potential role for RNA interference in controlling the activity of the human LINE-1 retrotransposon.

Functional polarity is introduced by Dicer processing of short substrate RNAs.

Respiratory syncytial virus nonstructural protein 2 specifically inhibits type I interferon signal transduction.

Progress towards in vivo use of siRNAs.

Characterization of modified antisense oligonucleotides in Xenopus laevis embryos.

Stable expression of shRNAs in human CD34+ progenitor cells can avoid induction of interferon responses to siRNAs in vitro.

A structural basis for discriminating between self and nonself double-stranded RNAs in mammalian cells.

Design of LNA probes that improve mismatch discrimination.

Rational design and in vitro and in vivo delivery of Dicer substrate siRNA.

Design of active small interfering RNAs.

Avoiding false-positive signals with nuclease-vulnerable molecular beacons in single living cells.

Advances in molecular and cellular therapies for hearing loss.

TLR7 is involved in sequence-specific sensing of single-stranded RNAs in human macrophages.

Predicting stability of DNA duplexes in solutions containing magnesium and monovalent cations.

Determinants of cytokine induction by small interfering RNA in human peripheral blood mononuclear cells.

Efficient cytosolic delivery of molecular beacon conjugates and flow cytometric analysis of target RNA.

Central delivery of Dicer-substrate siRNA: a direct application for pain research.

Chemical modification patterns compatible with high potency dicer-substrate small interfering RNAs.

Assessing the sensitivity of commercially available fluorophores to the intracellular environment.

Regulation of bacteria-induced intercellular adhesion molecule-1 by CCAAT/enhancer binding proteins.

Chitosan/siRNA nanoparticle-mediated TNF-alpha knockdown in peritoneal macrophages for anti-inflammatory treatment in a murine arthritis model.

A role for the Dicer helicase domain in the processing of thermodynamically unstable hairpin RNAs.

Chemical modification of siRNAs for in vivo use.

Gene silencing by synthetic U1 adaptors.

The beta3 subunit of the Na+,K+-ATPase mediates variable nociceptive sensitivity in the formalin test.

Sub-cellular trafficking and functionality of 2'-O-methyl and 2'-O-methyl-phosphorothioate molecular beacons.

Effects of chemical modification on the potency, serum stability, and immunostimulatory properties of short shRNAs.

Rational design of immunostimulatory siRNAs.

A direct comparison of anti-microRNA oligonucleotide potency.

Ratiometric bimolecular beacons for the sensitive detection of RNA in single living cells.

Genetic modulation of TLR8 response following bacterial phagocytosis.

Intraperitoneal administration of chitosan/DsiRNA nanoparticles targeting TNFα prevents radiation-induced fibrosis.

A role for human Dicer in pre-RISC loading of siRNAs.

miRNAs control insulin content in pancreatic β-cells via downregulation of transcriptional repressors.

siRNA-induced immunostimulation through TLR7 promotes antitumoral activity against HPV-driven tumors in vivo.

Analysis of microRNA turnover in mammalian cells following Dicer1 ablation.

Small nucleolar RNAs U32a, U33, and U35a are critical mediators of metabolic stress.

Nucleotide bias observed with a short SELEX RNA aptamer library.

RNase H-dependent PCR (rhPCR): improved specificity and single nucleotide polymorphism detection using blocked cleavable primers.

Synthesis and characterization of mannosylated pegylated polyethylenimine as a carrier for siRNA.

Protection against TNFα-dependent liver toxicity by intraperitoneal liposome delivered DsiRNA targeting TNFα in vivo.

Progress toward in vivo use of siRNAs-II.

Degradation of nuclease-stabilized RNA oligonucleotides in Mycoplasma-contaminated cell culture media.

Modulating Anti-MicroRNA-21 Activity and Specificity Using Oligonucleotide Derivatives and Length Optimization.

A miR-19 regulon that controls NF-κB signaling.

RNA aptamer-based functional ligands of the neurotrophin receptor, TrkB.

Pancreas-enriched miRNA refines endocrine cell differentiation.

Right- and left-loop short shRNAs have distinct and unusual mechanisms of gene silencing.

A microRNA network regulates expression and biosynthesis of wild-type and DeltaF508 mutant cystic fibrosis transmembrane conductance regulator.

RNA inhibition highlights cyclin D1 as a potential therapeutic target for mantle cell lymphoma.

Rapid identification of cell-specific, internalizing RNA aptamers with bioinformatics analyses of a cell-based aptamer selection.

Alternative RISC assembly: binding and repression of microRNA-mRNA duplexes by human Ago proteins.

In vivo SELEX for Identification of Brain-penetrating Aptamers.

Deep Sequencing Analyses of DsiRNAs Reveal the Influence of 3' Terminal Overhangs on Dicing Polarity, Strand Selectivity, and RNA Editing of siRNAs.

Manipulation of Cell Physiology Enables Gene Silencing in Well-differentiated Airway Epithelia.

Targeting IκB proteins for HIV latency activation: the role of individual IκB and NF-κB proteins.

Altered Purkinje cell miRNA expression and SCA1 pathogenesis.

Efficient delivery of RNA interference oligonucleotides to polarized airway epithelia in vitro.

Post-transcriptional regulation of cystic fibrosis transmembrane conductance regulator expression and function by microRNAs.

U1 Adaptor Oligonucleotides Targeting BCL2 and GRM1 Suppress Growth of Human Melanoma Xenografts In Vivo.

Spinal NTS2 receptor activation reverses signs of neuropathic pain.

Quantitative assessment of ratiometric bimolecular beacons as a tool for imaging single engineered RNA transcripts and measuring gene expression in living cells.

Improved Performance of Anti-miRNA Oligonucleotides Using a Novel Non-Nucleotide Modifier.

SNP detection in mRNA in living cells using allele specific FRET probes.

Knockdown of β-catenin with dicer-substrate siRNAs reduces liver tumor burden in vivo.

In vivo comparison of local versus systemic delivery of immunostimulating siRNA in HPV-driven tumours.

Inosine-mediated modulation of RNA sensing by Toll-like receptor 7 (TLR7) and TLR8.

Correction: SNP Detection in mRNA in Living Cells Using Allele Specific FRET Probes.

Imaging the directed transport of single engineered RNA transcripts in real-time using ratiometric bimolecular beacons.

Noninvasive imaging of Staphylococcus aureus infections with a nuclease-activated probe.

Platelet Activating Factor Receptor Activation Improves siRNA Uptake and RNAi Responses in Well-differentiated Airway Epithelia.