Kevin D. Foust

Recombinant adeno-associated viral vectors as therapeutic agents to treat neurological disorders.

Neonatal intraperitoneal or intravenous injections of recombinant adeno-associated virus type 8 transduce dorsal root ganglia and lower motor neurons.

Recombinant adeno-associated virus-mediated global anterograde delivery of glial cell line-derived neurotrophic factor to the spinal cord: comparison of rubrospinal and corticospinal tracts in the rat.

Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytes.

Nigrostriatal rAAV-mediated GDNF overexpression induces robust weight loss in a rat model of age-related obesity.

AAV as a gene transfer vector for the treatment of neurological disorders: novel treatment thoughts for ALS.

Over the barrier and through the blood: to CNS delivery we go.

Rescue of the spinal muscular atrophy phenotype in a mouse model by early postnatal delivery of SMN.

Early heart failure in the SMNDelta7 model of spinal muscular atrophy and correction by postnatal scAAV9-SMN delivery.

A role for glia in the progression of Rett's syndrome.

Systemic gene delivery in large species for targeting spinal cord, brain, and peripheral tissues for pediatric disorders.

Astrocytes from familial and sporadic ALS patients are toxic to motor neurons.

Recombinant AAV delivery to the central nervous system.

A single administration of morpholino antisense oligomer rescues spinal muscular atrophy in mouse.

Adeno-associated virus serotype 9 transduction in the central nervous system of nonhuman primates.

Targeted delivery of self-complementary adeno-associated virus serotype 9 to the brain, using magnetic resonance imaging-guided focused ultrasound.

Systemic delivery of MeCP2 rescues behavioral and cellular deficits in female mouse models of Rett syndrome.

Therapeutic AAV9-mediated suppression of mutant SOD1 slows disease progression and extends survival in models of inherited ALS.

Microglia induce motor neuron death via the classical NF-κB pathway in amyotrophic lateral sclerosis.

Improving single injection CSF delivery of AAV9-mediated gene therapy for SMA - a dose response study in mice and nonhuman primates.

Intravenous AAV9 efficiently transduces myenteric neurons in neonate and juvenile mice.