Mahendra S. Rao

Stable expression of the alkaline phosphatase marker gene by neural cells in culture and after transplantation into the CNS using cells derived from a transgenic rat.

Isolation of a glial-restricted tripotential cell line from embryonic spinal cord cultures.

Isolation of stem and precursor cells from fetal tissue.

Oligodendrocyte and astrocyte development in rodents: an in situ and immunohistological analysis during embryonic development.

Grafted lineage-restricted precursors differentiate exclusively into neurons in the adult spinal cord.

Properties of a fetal multipotent neural stem cell (NEP cell).

Transdifferentiation--fact or artifact.

Disruption of neurogenesis by amyloid beta-peptide, and perturbed neural progenitor cell homeostasis, in models of Alzheimer's disease.

Neural stem cells in aging and disease.

Stem cell and precursor cell therapy.

Hes1 but not Hes5 regulates an astrocyte versus oligodendrocyte fate choice in glial restricted precursors.

Nitric oxide acts in a positive feedback loop with BDNF to regulate neural progenitor cell proliferation and differentiation in the mammalian brain.

The stem-cell menagerie.

Identifying and tracking neural stem cells.

A central nervous system specific mouse model for thanatophoric dysplasia type II.

Distinguishing features of progenitor cells in the late embryonic and adult hippocampus.

Toward cell replacement therapy: promises and caveats.

Transplantation of glial-restricted precursor cells into the adult spinal cord: survival, glial-specific differentiation, and preferential migration in white matter.

Olig genes are expressed in a heterogeneous population of precursor cells in the developing spinal cord.

Membrane properties of rat embryonic multipotent neural stem cells.

Glutamate transporter expression and function in human glial progenitors.

Properties of four human embryonic stem cell lines maintained in a feeder-free culture system.

Long-term culture of human embryonic stem cells in feeder-free conditions.

Neural stem cell therapy in the aging brain: pitfalls and possibilities.

Gene expression in human embryonic stem cell lines: unique molecular signature.

Differences between human and mouse embryonic stem cells.

Glial progenitors in the CNS and possible lineage relationships among them.

Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.

Properties of pluripotent human embryonic stem cells BG01 and BG02.

In search of "stemness".

CD44 overexpression by oligodendrocytes: a novel mouse model of inflammation-independent demyelination and dysmyelination.

CD44 expression identifies astrocyte-restricted precursor cells.

Dopaminergic differentiation of human embryonic stem cells.

Aging and neuronal replacement.

Cellular lifespan and senescence signaling in embryonic stem cells.

Stem sense: a proposal for the classification of stem cells.

Glial restricted precursors protect against chronic glutamate neurotoxicity of motor neurons in vitro.

Karyotypic stability, genotyping, differentiation, feeder-free maintenance, and gene expression sampling in three human embryonic stem cell lines derived prior to August 9, 2001.

Monitoring early differentiation events in human embryonic stem cells by massively parallel signature sequencing and expressed sequence tag scan.

Endogenous Nkx2.2+/Olig2+ oligodendrocyte precursor cells fail to remyelinate the demyelinated adult rat spinal cord in the absence of astrocytes.

Fate of immortalized human neuronal progenitor cells transplanted in rat spinal cord.

Characterization of progenitor-cell-specific genes identified by subtractive suppression hybridization.

BG01V: a variant human embryonic stem cell line which exhibits rapid growth after passaging and reliable dopaminergic differentiation.

Functional SDF1 alpha/CXCR4 signaling in the developing spinal cord.

Neural precursor cells can be delivered into the injured cervical spinal cord by intrathecal injection at the lumbar cord.

Immortalized neural stem cells differ from nonimmortalized cortical neurospheres and cerebellar granule cell progenitors.

Sox2 expression defines a heterogeneous population of neurosphere-forming cells in the adult murine brain.

Monitoring differentiation of human embryonic stem cells using real-time PCR.

Hyaluronan accumulates in demyelinated lesions and inhibits oligodendrocyte progenitor maturation.

Comparison of the gene expression profile of undifferentiated human embryonic stem cell lines and differentiating embryoid bodies.

Human umbilical cord matrix stem cells: preliminary characterization and effect of transplantation in a rodent model of Parkinson's disease.

Conservation and variation of gene regulation in embryonic stem cells assessed by comparative genomics.

Establishing standards for the characterization of human embryonic stem cell lines.

Assessing self-renewal and differentiation in human embryonic stem cell lines.

Characterization of a new NIH-registered variant human embryonic stem cell line, BG01V: a tool for human embryonic stem cell research.

Translational research: toward better characterization of human embryonic stem cell lines.

Stem cells: shibboleths of development, part II: Toward a functional definition.

NTera2: a model system to study dopaminergic differentiation of human embryonic stem cells.

Development of antibodies to human embryonic stem cell antigens.

Brg1 is required for murine neural stem cell maintenance and gliogenesis.

Neurogenesis in Talpha-1 tubulin transgenic mice during development and after injury.

An efficient method for the derivation of mouse embryonic stem cells.

A focused microarray to assess dopaminergic and glial cell differentiation from fetal tissue or embryonic stem cells.

SDF1alpha/CXCR4 signaling stimulates beta-catenin transcriptional activity in rat neural progenitors.

Estimating human embryonic stem-cell numbers.

Differential fate of multipotent and lineage-restricted neural precursors following transplantation into the adult CNS.

Characterization and in vitro differentiation potential of a new human embryonic stem cell line, ReliCellhES1.

How many human embryonic stem cell lines are sufficient? A U.S. perspective.

Are there morally acceptable alternatives to blastocyst derived ESC?

Massively parallel signature sequencing profiling of fetal human neural precursor cells.

Transcriptome coexpression map of human embryonic stem cells.

Genome wide profiling of human embryonic stem cells (hESCs), their derivatives and embryonal carcinoma cells to develop base profiles of U.S. Federal government approved hESC lines.

Embryonic stem cell research and U.S. policy.

Cytoplasmic translocation of Olig2 in adult glial progenitors marks the generation of reactive astrocytes following autoimmune inflammation.

Inflammation stimulates myelination by transplanted oligodendrocyte precursor cells.

Derivation and characterization of neuronal precursors and dopaminergic neurons from human embryonic stem cells in vitro.

Designing, testing, and validating a microarray for stem cell characterization.

Massively parallel signature sequencing.

Large-scale analysis of neural stem cells and progenitor cells.

A molecular scheme for improved characterization of human embryonic stem cell lines.

Schwann cell-like differentiation by adult oligodendrocyte precursor cells following engraftment into the demyelinated spinal cord is BMP-dependent.

The therapeutic potential of embryonic stem cells: A focus on stem cell stability.

Mired in the quagmire of uncertainty: The "catch-22" of embryonic stem cell research.

Cross-species transcriptional profiles establish a functional portrait of embryonic stem cells.

Mechanisms controlling embryonic stem cell self-renewal and differentiation.

An in vitro model of human dopaminergic neurons derived from embryonic stem cells: MPP+ toxicity and GDNF neuroprotection.

Human embryonic stem cells.

Whole genome analysis of human neural stem cells derived from embryonic stem cells and stem and progenitor cells isolated from fetal tissue.

Stem cell myths.

Qualification of embryonal carcinoma 2102Ep as a reference for human embryonic stem cell research.

Truncated tyrosine kinase B brain-derived neurotrophic factor receptor directs cortical neural stem cells to a glial cell fate by a novel signaling mechanism.

Stage-dependent Olig2 expression in motor neurons and oligodendrocytes differentiated from embryonic stem cells.

Revisiting the astrocyte-oligodendrocyte relationship in the adult CNS.

A panel of tests to standardize the characterization of human embryonic stem cells.

Increased dentate neurogenesis after grafting of glial restricted progenitors or neural stem cells in the aging hippocampus.

Evidence that nucleocytoplasmic Olig2 translocation mediates brain-injury-induced differentiation of glial precursors to astrocytes.

Impaired SDF1/CXCR4 signaling in glial progenitors derived from SOD1(G93A) mice.

Disease progression after bone marrow transplantation in a model of multiple sclerosis is associated with chronic microglial and glial progenitor response.

Self-renewal of human embryonic stem cells requires insulin-like growth factor-1 receptor and ERBB2 receptor signaling.

The microenvironment of the embryonic neural stem cell: lessons from adult niches?

Patterns of laminins and integrins in the embryonic ventricular zone of the CNS.

Creation of engineered human embryonic stem cell lines using phiC31 integrase.

Adult glial precursor proliferation in mutant SOD1G93A mice.

A large-scale proteomic analysis of human embryonic stem cells.

Gene expression profile of neuronal progenitor cells derived from hESCs: activation of chromosome 11p15.5 and comparison to human dopaminergic neurons.

Generation and transplantation of dopaminergic neurons derived from embryonic stem cells.

Stem cells for the treatment of neurological disorders.

PDGF, TGF-beta, and FGF signaling is important for differentiation and growth of mesenchymal stem cells (MSCs): transcriptional profiling can identify markers and signaling pathways important in differentiation of MSCs into adipogenic, chondrogenic, and osteogenic lineages.

Isolation of neural stem and precursor cells from rodent tissue.

Controlled genetic modification of stem cells for developing drug discovery tools and novel therapeutic applications.

Regulatory networks define phenotypic classes of human stem cell lines.

Cell-extracellular matrix interactions regulate neural differentiation of human embryonic stem cells.

Evolutionarily conserved transcriptional co-expression guiding embryonic stem cell differentiation.

Focal transplantation-based astrocyte replacement is neuroprotective in a model of motor neuron disease.

Expression profiling of human glial precursors.

Generation of platform human embryonic stem cell lines that allow efficient targeting at a predetermined genomic location.

Neural transplantation and stem cells.

Self-renewal and differentiation capabilities are variable between human embryonic stem cell lines I3, I6 and BG01V.

A targeted neuroglial reporter line generated by homologous recombination in human embryonic stem cells.

Developing safe therapies from human pluripotent stem cells.

Xeno-free defined conditions for culture of human embryonic stem cells, neural stem cells and dopaminergic neurons derived from them.

beta1 integrin maintains integrity of the embryonic neocortical stem cell niche.

Identification by automated screening of a small molecule that selectively eliminates neural stem cells derived from hESCs but not dopamine neurons.

Stage-specific role for shh in dopaminergic differentiation of human embryonic stem cells induced by stromal cells.

Human cord blood stem cell applications in cell therapy.

Markers of murine embryonic and neural stem cells, neurons and astrocytes: reference points for developmental neurotoxicity testing.

Global Characterization and Genomic Stability of Human MultiStem, A Multipotent Adult Progenitor Cell.

A novel serum-free medium for the expansion of human mesenchymal stem cells.

Efficient generation of functional dopaminergic neurons from human induced pluripotent stem cells under defined conditions.

Seeing is believing: are cancer stem cells the Loch Ness monster of tumor biology?

Mesenchymal stem cell assays and applications.

Concise review: non-cell autonomous reprogramming: a nucleic acid-free approach to induction of pluripotency.

Chromatin insulator elements block transgene silencing in engineered human embryonic stem cell lines at a defined chromosome 13 locus.

Funding translational work in cell-based therapy.

Cell-based therapy for neural disorders--anticipating challenges.

Human glial-restricted progenitor transplantation into cervical spinal cord of the SOD1 mouse model of ALS.

Novel live alkaline phosphatase substrate for identification of pluripotent stem cells.

Stromal factors SDF1α, sFRP1, and VEGFD induce dopaminergic neuron differentiation of human pluripotent stem cells.

Assessing iPSC reprogramming methods for their suitability in translational medicine.

Cell therapy in critical limb ischemia: current developments and future progress.

Evaluation of cholesterol reduction activity of methyl-β-cyclodextrin using differentiated human neurons and astrocytes.

Nucleic acid and non-nucleic acid-based reprogramming of adult limbal progenitors to pluripotency.

Steering a new course for stem cell research: NIH's intramural Center for Regenerative Medicine.

Human neural crest stem cells derived from human ESCs and induced pluripotent stem cells: induction, maintenance, and differentiation into functional schwann cells.

Efficient generation of astrocytes from human pluripotent stem cells in defined conditions.

Using human pluripotent stem cell-derived dopaminergic neurons to evaluate candidate Parkinson's disease therapeutic agents in MPP+ and rotenone models.

A review of the methods for human iPSC derivation.

Optimizing dopaminergic differentiation of pluripotent stem cells for the manufacture of dopaminergic neurons for transplantation.

Pluripotent stem cells in translation: a Food and Drug Administration-National Institutes of Health collaboration.

hESC-derived Olig2+ progenitors generate a subtype of astroglia with protective effects against ischaemic brain injury.

Tumorigenicity as a clinical hurdle for pluripotent stem cell therapies.

LULL(ed) into complacency: a perspective on licenses and stem cell translational science.

Functional screening assays with neurons generated from pluripotent stem cell-derived neural stem cells.

Genome wide profiling of dopaminergic neurons derived from human embryonic and induced pluripotent stem cells.

RISC in PD: the impact of microRNAs in Parkinson's disease cellular and molecular pathogenesis.

Comparison of the molecular profiles of human embryonic and induced pluripotent stem cells of isogenic origin.

Soliciting strategies for developing cell-based reference materials to advance mesenchymal stromal cell research and clinical translation.

Genetic Modification in Human Pluripotent Stem Cells by Homologous Recombination and CRISPR/Cas9 System.

Stable enhanced green fluorescent protein expression after differentiation and transplantation of reporter human induced pluripotent stem cells generated by AAVS1 transcription activator-like effector nucleases.

Survival and engraftment of dopaminergic neurons manufactured by a Good Manufacturing Practice-compatible process.

Compounds with species and cell type specific toxicity identified in a 2000 compound drug screen of neural stem cells and rat mixed cortical neurons.

Banking on iPSC- Is it Doable and is it Worthwhile.

Need for DISCUSS(ion).