Lei Fang

PTEN-L is a novel protein phosphatase for ubiquitin dephosphorylation to inhibit PINK1-Parkin-mediated mitophagy.

[A fast non-local means algorithm for denoising of computed tomography images].

TNF-α impairs differentiation and function of TGF-β-induced Treg cells in autoimmune diseases through Akt and Smad3 signaling pathway.

Occurrence of glycerol uptake in Dunaliella tertiolecta under hyperosmotic stress.

Inactivation of MARCH5 prevents mitochondrial fragmentation and interferes with cell death in a neuronal cell model.

Current progresses of novel natural products and their derivatives/ analogs as anti-Alzheimer candidates: an update.

Propylene glycol-linked amino acid/dipeptide diester prodrugs of oleanolic acid for PepT1-mediated transport: synthesis, intestinal permeability, and pharmacokinetics.

Synthesis of cationic polylactides with tunable charge densities as nanocarriers for effective gene delivery.

Design and synthesis of dimethylaminomethyl-substituted curcumin derivatives/analogues: potent antitumor and antioxidant activity, improved stability and aqueous solubility compared with curcumin.

Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-α in rheumatoid arthritis.

Scalable and selective dispersion of semiconducting arc-discharged carbon nanotubes by dithiafulvalene/thiophene copolymers for thin film transistors.

Integrated materials design of organic semiconductors for field-effect transistors.

Continual production of glycerol from carbon dioxide by Dunaliella tertiolecta.

Secondary metabolites from the endophytic fungi Penicillium polonicum and Aspergillus fumigatus.

Meningothelial cells as part of the central nervous system host defense.

A universal pedicle screw and V-rod system for lumbar isthmic spondylolysis: a retrospective analysis of 21 cases.

Cigarette smoke component acrolein modulates chromatin assembly by inhibiting histone acetylation.

Improved heterologous erythromycin A production through expression plasmid re-design.

Preparation and in vivo characterization of a cocaine hydrolase engineered from human butyrylcholinesterase for metabolizing cocaine.

Evaluation of the effects of food on the single-dose pharmacokinetics of trametinib, a first-in-class MEK inhibitor, in patients with cancer.

Large-scale separation of alkaloids from Gelsemium elegans by pH-zone-refining counter-current chromatography with a new solvent system screening method.

Adult Hirschsprung's disease: report of four cases.

Pneumocystis jiroveci pneumonia in patients with non-Hodgkin's lymphoma after Rituximab-containing regimen: two cases of report and literature review.

Synthesis and anticancer activity of some novel 2-phenazinamine derivatives.

Substrate selectivity of high-activity mutants of human butyrylcholinesterase.

Degradation of atenolol by UV/peroxymonosulfate: kinetics, effect of operational parameters and mechanism.

Fundamental reaction pathway for peptide metabolism by proteasome: insights from first-principles quantum mechanical/molecular mechanical free energy calculations.

Platinum(II) complexes with N-monoalkyl 1R,2R-diaminocyclohexane derivatives as carrier ligands and 3-hydroxycyclobutane-1,1-dicarboxylate as a leaving group: potent cytotoxicity and DNA binding ability.

MARCH5 inactivation supports mitochondrial function during neurodegenerative stress.

De novo transcriptome profiling uncovers a drastic downregulation of photosynthesis upon nitrogen deprivation in the nonmodel green alga Botryosphaerella sudeticus.

Shuang-Huang-Lian exerts anti-inflammatory and anti-oxidative activities in lipopolysaccharide-stimulated murine alveolar macrophages.

Bisindole alkaloids with neural anti-inflammatory activity from Gelsemium elegans.

Curcumol exhibits anti-inflammatory properties by interfering with the JNK-mediated AP-1 pathway in lipopolysaccharide-activated RAW264.7 cells.

A model of glycosylated human butyrylcholinesterase.

Ruthmycin, a new tetracyclic polyketide from Streptomyces sp. RM-4-15.

Design, synthesis and anti-Alzheimer properties of dimethylaminomethyl-substituted curcumin derivatives.

TLR2 mediates phagocytosis and autophagy through JNK signaling pathway in Staphylococcus aureus-stimulated RAW264.7 cells.

Combination of amino acid/dipeptide with nitric oxide donating oleanolic acid derivatives as PepT1 targeting antitumor prodrugs.

Comparison of Uv/PDS and UV/H2O2 processes for the degradation of atenolol in water.

Anti-inflammatory response following uptake of apoptotic bodies by meningothelial cells.

Amino-acid mutations to extend the biological half-life of a therapeutically valuable mutant of human butyrylcholinesterase.

Design, synthesis and biological evaluation of D-ring opened galantamine analogs as multifunctional anti-Alzheimer agents.

Author Correction: PTEN-L is a novel protein phosphatase for ubiquitin dephosphorylation to inhibit PINK1-Parkin-mediated mitophagy.

Concomitant oral and intravenous pharmacokinetics of trametinib, a MEK inhibitor, in subjects with solid tumours.

DNA microarray analysis reveals that antibiotic resistance-gene diversity in human gut microbiota is age related.

High performance all-polymer solar cell via polymer side-chain engineering.

Transmigration and phagocytosis of macrophages in an airway infection model using four-dimensional techniques.

Rhein exerts pro- and anti-inflammatory actions by targeting IKKβ inhibition in LPS-activated macrophages.

Suppressive effects of irisflorentin on LPS-induced inflammatory responses in RAW 264.7 macrophages.

Transcriptomic analysis of fiber strength in upland cotton chromosome introgression lines carrying different Gossypium barbadense chromosomal segments.

Integration of modeling and simulation to support changes to ondansetron dosing following a randomized, double-blind, placebo-, and active-controlled thorough QT study.

Genkwanin inhibits proinflammatory mediators mainly through the regulation of miR-101/MKP-1/MAPK pathway in LPS-activated macrophages.

Expression and effects of JMJD2A histone demethylase in endometrial carcinoma.

Rational design, preparation, and characterization of a therapeutic enzyme mutant with improved stability and function for cocaine detoxification.

[Mechanism of signal molecule high mobility group box protein 1 mediated by Toll-like receptor 2 in murine asthma].

Heat shock protein 70 from Trichinella spiralis induces protective immunity in BALB/c mice by activating dendritic cells.

AR-regulated TWEAK-FN14 pathway promotes prostate cancer bone metastasis.

High fever as an initial symptom of primary gastric inflammatory myofibroblastic tumor in an adult woman.

Loss of EGFR signaling regulated miR-203 promotes prostate cancer bone metastasis and tyrosine kinase inhibitors resistance.

Comparison of the endothelial toxicity induced by short-term amiodarone and diazepam exposure in a human umbilical vein endothelial cell line (EVC304).

Environmental-stress-induced Chromatin Regulation and its Heritability.

The new phase [Tl₄Sb₆Se₁₀][Sn₅Sb₂Se₁₄]: a naturally formed semiconducting heterostructure with two-dimensional conductance.

[Comparison on surface ultrastructure characteristic and drought resistance of different Trichosanthes kirilowii strains].

Assessment of the effect of ofatumumab on cardiac repolarization.

Implementation and evaluation of the chronic-disease self-management program among Chinese immigrant older adults in the U.S.

Lack of clinically significant pharmacokinetic interaction between the thrombopoietin receptor agonist eltrombopag and hepatitis C virus protease inhibitors boceprevir and telaprevir.

High-quality draft genome sequence of nematocidal Bacillus thuringiensis Sbt003.

Arsenic induces polyadenylation of canonical histone mRNA by down-regulating stem-loop-binding protein gene expression.

Cotton fiber elongation network revealed by expression profiling of longer fiber lines introgressed with different Gossypium barbadense chromosome segments.

[Effects of plant-derived smoke water on accumulation of biomass and active substance of Salvia miltiorrhiza f. alba].

Design and synthesis of Lapatinib derivatives containing a branched side chain as HER1/HER2 targeting antitumor drug candidates.

The effect of flammer-syndrome on retinal venous pressure.

Postsynthetic lanthanide functionalization of nanosized metal-organic frameworks for highly sensitive ratiometric luminescent thermometry.

Application of chitosan microparticles for reduction of vibrio species in seawater and live oysters (Crassostrea virginica).

Repeated inhalation of sevoflurane inhibits airway inflammation in an OVA-induced mouse model of allergic airway inflammation.

Safety and efficacy of laparoscopy-assisted gastrectomy for advanced gastric cancer in the elderly.

The BRCA1/2-directed miRNA signature predicts a good prognosis in ovarian cancer patients with wild-type BRCA1/2.

Exploring the association between interleukin-1β and its interacting proteins in Alzheimer's disease.

[Curative effects of kinesitherapy in combination with self-made simple orthosis in treatment of scar contracture of burned hand in children].

Two-dimensional mineral [Pb2BiS3][AuTe2]: high-mobility charge carriers in single-atom-thick layers.

Pharmacophore modeling using site-identification by ligand competitive saturation (SILCS) with multiple probe molecules.

Evaluation of the intestinal transport of a phenylethanoid glycoside-rich extract from Cistanche deserticola across the Caco-2 cell monolayer model.

Mapping functional group free energy patterns at protein occluded sites: nuclear receptors and G-protein coupled receptors.

Construction of stable polymeric vesicles based on azobenzene and beta-cyclodextrin grafted poly(glycerol methacrylate)s for potential applications in colon-specific drug delivery.

Mitochondrial function in neuronal cells depends on p97/VCP/Cdc48-mediated quality control.

An Open-Label, Single-Arm, Phase 1 Study to Assess Biomarker Effects, Efficacy, and Safety of Ofatumumab in Patients With Refractory Chronic Lymphocytic Leukemia.

[Study on secondary metabolites of endophytic fungi Penicillium polonicum].

Loss of Androgen-Regulated MicroRNA 1 Activates SRC and Promotes Prostate Cancer Bone Metastasis.

A meta-analysis of the fusion rate from surgical treatment for odontoid factures: anterior odontoid screw versus posterior C1-C2 arthrodesis.

HOTAIR is a potential target for the treatment of cisplatin‑resistant ovarian cancer.

Erratum for Wire et al., Lack of Clinically Significant Pharmacokinetic Interaction between the Thrombopoietin Receptor Agonist Eltrombopag and Hepatitis C Virus Protease Inhibitors Boceprevir and Telaprevir.

A Potential New Mechanism of Arsenic Carcinogenesis: Depletion of Stem-Loop Binding Protein and Increase in Polyadenylated Canonical Histone H3.1 mRNA.

Sequencing of allotetraploid cotton (Gossypium hirsutum L. acc. TM-1) provides a resource for fiber improvement.

Shuang-huang-lian attenuates lipopolysaccharide-induced acute lung injury in mice involving anti-inflammatory and antioxidative activities.

Mechanisms Underlying Acrolein-Mediated Inhibition of Chromatin Assembly.

The effects of acetaldehyde exposure on histone modifications and chromatin structure in human lung bronchial epithelial cells.

HSPA12A is a Novel Player in Nonalcoholic Steatohepatitis via Promoting Nuclear PKM2-mediated M1 Macrophage Polarization.

A cytosolic chaperone complex controls folding and degradation of type III CD38.

Evidence for a role of geranylgeranylation in renal angiomyolipoma and renal epithelioid angiomyolipoma.

Significant Down-Regulation of Urea Cycle Generates Clinically Relevant Proteomic Signature in Hepatocellular Carcinoma Patients with Macrovascular Invasion.

The transferrin receptor CD71 regulates type II CD38, revealing tight topological compartmentalization of intracellular cyclic ADP-ribose production.

CENP-A Ubiquitylation Is Indispensable to Cell Viability.

Vitamin D Receptor Inhibits NLRP3 Activation by Impeding Its BRCC3-Mediated Deubiquitination.

FAM134B oligomerization drives endoplasmic reticulum membrane scission for ER-phagy.

Liver governs adipose remodelling via extracellular vesicles in response to lipid overload.

Global Phosphoproteomic Analysis Reveals Significant Metabolic Reprogramming in the Termination of Liver Regeneration in Mice.