Wiltrud Lederle

Platelet-derived growth factor-BB controls epithelial tumor phenotype by differential growth factor regulation in stromal cells.

Assessment of vascular remodeling under antiangiogenic therapy using DCE-MRI and vessel size imaging.

Distinct progression-associated expression of tumor and stromal MMPs in HaCaT skin SCCs correlates with onset of invasion.

MMP13 as a stromal mediator in controlling persistent angiogenesis in skin carcinoma.

Comparison of conventional time-intensity curves vs. maximum intensity over time for post-processing of dynamic contrast-enhanced ultrasound.

Platelet-derived growth factor-B normalizes micromorphology and vessel function in vascular endothelial growth factor-A-induced squamous cell carcinomas.

MMP inhibition blocks fibroblast-dependent skin cancer invasion, reduces vascularization and alters VEGF-A and PDGF-BB expression.

IL-6 promotes malignant growth of skin SCCs by regulating a network of autocrine and paracrine cytokines.

Molecular and functional ultrasound imaging in differently aggressive breast cancer xenografts using two novel ultrasound contrast agents (BR55 and BR38).

FMN-coated fluorescent iron oxide nanoparticles for RCP-mediated targeting and labeling of metabolically active cancer and endothelial cells.

Comparison of μCT, MRI and optical reflectance imaging for assessing the growth of GFP/RFP-expressing tumors.

Evaluation of high frequency ultrasound methods and contrast agents for characterising tumor response to anti-angiogenic treatment.

Failure of annexin-based apoptosis imaging in the assessment of antiangiogenic therapy effects.

Targeted near-infrared imaging of the erythropoietin receptor in human lung cancer xenografts.

Vascular endothelial growth factor-induced skin carcinogenesis depends on recruitment and alternative activation of macrophages.

Ultrasound microbubbles for molecular diagnosis, therapy, and theranostics.

High accuracy of mesoscopic epi-fluorescence tomography for non-invasive quantitative volume determination of fluorescent protein-expressing tumours in mice.

The high angiogenic activity in very early breast cancer enables reliable imaging with VEGFR2-targeted microbubbles (BR55).

Riboflavin carrier protein-targeted fluorescent USPIO for the assessment of vascular metabolism in tumors.

Molecular and functional ultrasound imaging of breast tumors.

Cell type specific interleukin-6 induced responses in tumor keratinocytes and stromal fibroblasts are essential for invasive growth.

Liver dysplasia: US molecular imaging with targeted contrast agent enables early assessment.

Regorafenib inhibits growth, angiogenesis and metastasis in a highly aggressive, orthotopic colon cancer model.

Phase shift variance imaging - a new technique for destructive microbubble imaging.

Ultrasound molecular imaging of E-selectin in tumor vessels using poly n-butyl cyanoacrylate microbubbles covalently coupled to a short targeting peptide.

A low molecular weight zinc2+-dipicolylamine-based probe detects apoptosis during tumour treatment better than an annexin V-based probe.

Micro-CT imaging of tumor angiogenesis: quantitative measures describing micromorphology and vascularization.

Recent advances in molecular, multimodal and theranostic ultrasound imaging.

Passive versus active tumor targeting using RGD- and NGR-modified polymeric nanomedicines.

Optical tomography of MMP activity allows a sensitive noninvasive characterization of the invasiveness and angiogenesis of SCC xenografts.

Influence of repetitive contrast agent injections on functional and molecular ultrasound measurements.

Absorption reconstruction improves biodistribution assessment of fluorescent nanoprobes using hybrid fluorescence-mediated tomography.

In-vivo detection of the erythropoietin receptor in tumours using positron emission tomography.

Bioactive gyroid scaffolds formed by sacrificial templating of nanocellulose and nanochitin hydrogels as instructive platforms for biomimetic tissue engineering.

RGD-decorated conjugated polymer particles as fluorescent biomedical probes prepared by Sonogashira dispersion polymerization.

Erythropoietin improves the accumulation and therapeutic effects of Carboplatin by enhancing tumor vascularization and perfusion.