Woo Jin Park

An engineered viral protease exhibiting substrate specificity for a polyglutamine stretch prevents polyglutamine-induced neuronal cell death.

SUMO1-dependent modulation of SERCA2a in heart failure.

Transcription coactivator Eya2 is a critical regulator of physiological hypertrophy.

Detection of site-specific proteolysis in secretory pathways.

Increased Ca2+ storage capacity in the sarcoplasmic reticulum by overexpression of HRC (histidine-rich Ca2+ binding protein).

Cell-based assay for beta-secretase activity.

Negatively charged amino acids within the intraluminal loop of ryanodine receptor are involved in the interaction with triadin.

Elucidation of the interactions between C99, presenilin, and nicastrin by the split-ubiquitin assay.

Identification of CED-3 substrates by a yeast-based screening method.

Regulation of myocardial function by histidine-rich, calcium-binding protein.

Structure-based virtual screening and biological evaluation of potent and selective ADAM12 inhibitors.

Complementary DNA cloning, genomic characterization and expression analysis of a mammalian gene encoding histidine-rich calcium binding protein.

Cloning and characterization of TMPRSS6, a novel type 2 transmembrane serine protease.

Altered patterns of gene expression in response to chronic atrial fibrillation.

Engineering of Kex2 variants exhibiting altered substrate specificity.

Histidine-rich Ca binding protein: a regulator of sarcoplasmic reticulum calcium sequestration and cardiac function.

PICOT inhibits cardiac hypertrophy and enhances ventricular function and cardiomyocyte contractility.

Neuronal vulnerability of CLN3 deletion to calcium-induced cytotoxicity is mediated by calsenilin.

Targeted gene transfer increases contractility and decreases oxygen cost of contractility in normal rat hearts.

Restoration of mechanical and energetic function in failing aortic-banded rat hearts by gene transfer of calcium cycling proteins.

Gene profiling during regression of pressure overload-induced cardiac hypertrophy.

Development of potent inhibitors of the coxsackievirus 3C protease.

An integrated genetic and functional analysis of the role of type II transmembrane serine proteases (TMPRSSs) in hearing loss.

Preservation of mechanical and energetic function after adenoviral gene transfer in normal rat hearts.

PICOT attenuates cardiac hypertrophy by disrupting calcineurin-NFAT signaling.

Identification of mouse heart transcriptomic network sensitive to various heart diseases.

Engineering of protease variants exhibiting altered substrate specificity.

Protection of cardiomyocytes from ischemic/hypoxic cell death via Drbp1 and pMe2GlyDH in cardio-specific ARC transgenic mice.

PICOT is a critical regulator of cardiac hypertrophy and cardiomyocyte contractility.

The transcription factor Eya2 prevents pressure overload-induced adverse cardiac remodeling.

A 4-year retrospective study of facial fractures on Jeju, Korea.

Retroperitoneal laparoendoscopic single-site surgery in urology: initial experience.

Parathyroid hormone accelerates decompensation following left ventricular hypertrophy.

Dehydropolymerization of 1,1-dihydrotetraphenylsilole and 1,1-dihydrotetraphenylgermole to optoelectronic copolymers catalyzed by colloidal silver nanoparticles.

The opposing effects of CCN2 and CCN5 on the development of cardiac hypertrophy and fibrosis.

Myosin regulatory light chains are required to maintain the stability of myosin II and cellular integrity.

The nuclear inclusion a (NIa) protease of turnip mosaic virus (TuMV) cleaves amyloid-β.

Receptor activator of nuclear factor-κB ligand is a novel inducer of myocardial inflammation.

PICOT increases cardiac contractility by inhibiting PKCζ activity.

Cardiomyocyte specific deficiency of serine palmitoyltransferase subunit 2 reduces ceramide but leads to cardiac dysfunction.

AAV-mediated knock-down of HRC exacerbates transverse aorta constriction-induced heart failure.

Identification of novel microRNAs negatively regulating cardiac hypertrophy.

Epigenetic reprogramming in somatic cells induced by extract from germinal vesicle stage pig oocytes.

Expression of the plant viral protease NIa in the brain of a mouse model of Alzheimer's disease mitigates Aβ pathology and improves cognitive function.

Decoy peptides targeted to protein phosphatase 1 inhibit dephosphorylation of phospholamban in cardiomyocytes.

Cardiomyocyte specific deletion of Crif1 causes mitochondrial cardiomyopathy in mice.

Caspase-3-mediated cleavage of PICOT in apoptosis.

Targeted ablation of the histidine-rich Ca(2+)-binding protein (HRC) gene is associated with abnormal SR Ca(2+)-cycling and severe pathology under pressure-overload stress.

SERCA2a: a prime target for modulation of cardiac contractility during heart failure.

NQO1 activation regulates angiotensin-converting enzyme shedding in spontaneously hypertensive rats.

Pharmacological activation of Sirt1 ameliorates polyglutamine-induced toxicity through the regulation of autophagy.

MG53-induced IRS-1 ubiquitination negatively regulates skeletal myogenesis and insulin signalling.

IGF-1 receptor deficiency in thyrocytes impairs thyroid hormone secretion and completely inhibits TSH-stimulated goiter.

Activation of Autophagy Pathway Suppresses the Expression of iNOS, IL6 and Cell Death of LPS-Stimulated Microglia Cells.

Residues Arg703, Asp777, and Arg781 of the RNase H domain of hepatitis B virus polymerase are critical for viral DNA synthesis.

Cucurbitacin B and cucurbitacin I suppress adipocyte differentiation through inhibition of STAT3 signaling.

SPIN90 knockdown attenuates the formation and movement of endosomal vesicles in the early stages of epidermal growth factor receptor endocytosis.

A novel mutation of TMPRSS3 related to milder auditory phenotype in Korean postlingual deafness: a possible future implication for a personalized auditory rehabilitation.

Regulation of acetylation of histone deacetylase 2 by p300/CBP-associated factor/histone deacetylase 5 in the development of cardiac hypertrophy.

Beta-lapachone inhibits pathological retinal neovascularization in oxygen-induced retinopathy via regulation of HIF-1α.

β-Lapachone ameliorates lipotoxic cardiomyopathy in acyl CoA synthase transgenic mice.

Inhibition of miR-25 improves cardiac contractility in the failing heart.

Intracellular amyloid beta alters the tight junction of retinal pigment epithelium in 5XFAD mice.

Ablation of cereblon attenuates myocardial ischemia-reperfusion injury.

Intracellular cleavage of amyloid β by a viral protease NIa prevents amyloid β-mediated cytotoxicity.

Hydroesterification of alkenes with sodium formate and alcohols promoted by cooperative catalysis of Ru3(CO)12 and 2-pyridinemethanol.

Gallic acid regulates body weight and glucose homeostasis through AMPK activation.

β-Lapachone attenuates mitochondrial dysfunction in MELAS cybrid cells.

Pik3ip1 modulates cardiac hypertrophy by inhibiting PI3K pathway.

MiR-195a Inhibits Adipocyte Differentiation by Targeting the Preadipogenic Determinator Zfp423.

The FDA approved drug irbesartan inhibits HBV-infection in HepG2 cells stably expressing sodium taurocholate co-transporting polypeptide.