Chien-Kuo Lee
Graduate Institute of Immunology
National Taiwan University College of Medicine
Chien-Kuo Lee is a Professor in the Graduate Institute of Immunology, National Taiwan University College of Medicine. He received a Ph.D. degree in 1998 at New York University School of Medicine, USA.
Dr. Lee did his postdoctoral trainings at NYUSM and National Institute for Medical Research, UK (1998-2002). He has been interested in cytokine signal transduction and unveiling the roles of type I IFN and its downstream signal mediators, particularly STAT1 and STAT3, in immunomodulation, including dendritic cell development and functions, B cell differentiation and antiviral response.
What does Stat3 do?
The Journal of clinical investigation May, 2002 | Pubmed ID: 11994402
STAT3 is a negative regulator of granulopoiesis but is not required for G-CSF-dependent differentiation.
Immunity Jul, 2002 | Pubmed ID: 12150892
Tissue-specific positive feedback requirements for production of type I interferon following virus infection.
The Journal of biological chemistry May, 2005 | Pubmed ID: 15767254
Stat1 and Stat2 but not Stat3 arbitrate contradictory growth signals elicited by alpha/beta interferon in T lymphocytes.
Molecular and cellular biology Jul, 2005 | Pubmed ID: 15964802
STAT3 positively regulates an early step in B-cell development.
Blood Nov, 2006 | Pubmed ID: 16825489
Tie2-R849W mutant in venous malformations chronically activates a functional STAT1 to modulate gene expression.
The Journal of investigative dermatology Sep, 2008 | Pubmed ID: 18401423
CLEC5A is critical for dengue-virus-induced lethal disease.
Nature May, 2008 | Pubmed ID: 18496526
STAT2 hypomorphic mutant mice display impaired dendritic cell development and antiviral response.
Journal of biomedical science , 2009 | Pubmed ID: 19272190
Suppressor of cytokine signaling and accelerated atherosclerosis in kidney disease.
Acta biochimica Polonica , 2010 | Pubmed ID: 20725646
STAT3 negatively regulates type I IFN-mediated antiviral response.
Journal of immunology (Baltimore, Md. : 1950) Sep, 2011 | Pubmed ID: 21810606
Intrahepatic infiltrating NK and CD8 T cells cause liver cell death in different phases of dengue virus infection.
PloS one , 2012 | Pubmed ID: 23050007
A type I IFN-Flt3 ligand axis augments plasmacytoid dendritic cell development from common lymphoid progenitors.
The Journal of experimental medicine Nov, 2013 | Pubmed ID: 24145513
Immunodeficient mouse models with different disease profiles by in vivo infection with the same clinical isolate of enterovirus 71.
Journal of virology Nov, 2014 | Pubmed ID: 25142603
The pathological effects of CCR2+ inflammatory monocytes are amplified by an IFNAR1-triggered chemokine feedback loop in highly pathogenic influenza infection.
Journal of biomedical science , 2014 | Pubmed ID: 25407417
STAT2/IRF9 directs a prolonged ISGF3-like transcriptional response and antiviral activity in the absence of STAT1.
The Biochemical journal Mar, 2015 | Pubmed ID: 25564224
Effects of RING-SH2Grb², a chimeric protein containing the E3 ligase domain of Cbl, on the EGFR pathway.
The Chinese journal of physiology Dec, 2014 | Pubmed ID: 25575524
An alternatively spliced IL-15 isoform modulates abrasion-induced keratinocyte activation.
The Journal of investigative dermatology May, 2015 | Pubmed ID: 25615554
Efficient Generation of Plasmacytoid Dendritic Cell from Common Lymphoid Progenitors by Flt3 Ligand.
PloS one , 2015 | Pubmed ID: 26263178
STAT1 regulates marginal zone B cell differentiation in response to inflammation and infection with blood-borne bacteria.
The Journal of experimental medicine 12, 2016 | Pubmed ID: 27849553
Antibodies against nonstructural protein 1 protect mice from dengue virus-induced mast cell activation.
Laboratory investigation; a journal of technical methods and pathology Feb, 2017 | Pubmed ID: 28240747
Phosphodiesterase 4B negatively regulates endotoxin-activated interleukin-1 receptor antagonist responses in macrophages.
Scientific reports 04, 2017 | Pubmed ID: 28383060
Therapeutic Effects of Monoclonal Antibody against Dengue Virus NS1 in a STAT1 Knockout Mouse Model of Dengue Infection.
Journal of immunology (Baltimore, Md. : 1950) 10, 2017 | Pubmed ID: 28904127
Signal Integration of IFN-I and IFN-II With TLR4 Involves Sequential Recruitment of STAT1-Complexes and NFκB to Enhance Pro-inflammatory Transcription.
Frontiers in immunology , 2019 | Pubmed ID: 31231385
Fine-Tuning of Type I Interferon Response by STAT3.
Frontiers in immunology , 2019 | Pubmed ID: 31293595
Editorial: STATs and IRFs in Innate Immunity: From Transcriptional Regulators to Therapeutic Targets.
Frontiers in immunology , 2019 | Pubmed ID: 31447843
In Vitro Generation of Murine Plasmacytoid Dendritic Cells from Common Lymphoid Progenitors using the AC-6 Feeder System
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