Sudarshan Rajagopal

The LOV domain family: photoresponsive signaling modules coupled to diverse output domains.

Crystal structure of a photoactive yellow protein from a sensor histidine kinase: conformational variability and signal transduction.

Application of singular value decomposition to the analysis of time-resolved macromolecular x-ray data.

Protein kinetics: structures of intermediates and reaction mechanism from time-resolved x-ray data.

Analysis of experimental time-resolved crystallographic data by singular value decomposition.

Chromophore conformation and the evolution of tertiary structural changes in photoactive yellow protein.

Analytical trapping: extraction of time-independent structures from time-dependent crystallographic data.

Purification and initial characterization of a putative blue light-regulated phosphodiesterase from Escherichia coli.

A structural pathway for signaling in the E46Q mutant of photoactive yellow protein.

Visualizing reaction pathways in photoactive yellow protein from nanoseconds to seconds.

Total chemical synthesis and biophysical characterization of the minimal isoform of the KChIP2 potassium channel regulatory subunit.

Beta-arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7.

Teaching old receptors new tricks: biasing seven-transmembrane receptors.

Global phosphorylation analysis of beta-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR).

Therapeutic potential of β-arrestin- and G protein-biased agonists.

Quantifying ligand bias at seven-transmembrane receptors.

Multiple ligand-specific conformations of the β2-adrenergic receptor.

A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1.

Distinct phosphorylation sites on the β(2)-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin.

Quantifying biased agonism: understanding the links between affinity and efficacy.

Biased Agonism as a Mechanism for Differential Signaling by Chemokine Receptors.

Right ventricular mechanics using a novel comprehensive three-view echocardiographic strain analysis in a normal population.

Comprehensive assessment of right ventricular function in patients with pulmonary hypertension with global longitudinal peak systolic strain derived from multiple right ventricular views.

Monitoring protein conformational changes and dynamics using stable-isotope labeling and mass spectrometry.

What is biased efficacy? Defining the relationship between intrinsic efficacy and free energy coupling.

The influence of angle of insonation and target depth on speckle-tracking strain.

Use of outcome measures in pulmonary hypertension clinical trials.

Safety and Tolerability of High-dose Inhaled Treprostinil in Pulmonary Hypertension.

The β-arrestins: Multifunctional regulators of G protein-coupled receptors.