Department of Medicine
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The LOV domain family: photoresponsive signaling modules coupled to diverse output domains.
Biochemistry Jan, 2003 | Pubmed ID: 12515534
Crystal structure of a photoactive yellow protein from a sensor histidine kinase: conformational variability and signal transduction.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2003 | Pubmed ID: 12563032
Application of singular value decomposition to the analysis of time-resolved macromolecular x-ray data.
Biophysical journal Mar, 2003 | Pubmed ID: 12609912
Protein kinetics: structures of intermediates and reaction mechanism from time-resolved x-ray data.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2004 | Pubmed ID: 15041745
Analysis of experimental time-resolved crystallographic data by singular value decomposition.
Acta crystallographica. Section D, Biological crystallography May, 2004 | Pubmed ID: 15103131
Chromophore conformation and the evolution of tertiary structural changes in photoactive yellow protein.
Structure (London, England : 1993) Jun, 2004 | Pubmed ID: 15274923
Analytical trapping: extraction of time-independent structures from time-dependent crystallographic data.
Journal of structural biology Sep, 2004 | Pubmed ID: 15450291
Purification and initial characterization of a putative blue light-regulated phosphodiesterase from Escherichia coli.
Photochemistry and photobiology Nov-Dec, 2004 | Pubmed ID: 15453820
A structural pathway for signaling in the E46Q mutant of photoactive yellow protein.
Structure (London, England : 1993) Jan, 2005 | Pubmed ID: 15642261
Visualizing reaction pathways in photoactive yellow protein from nanoseconds to seconds.
Proceedings of the National Academy of Sciences of the United States of America May, 2005 | Pubmed ID: 15870207
Total chemical synthesis and biophysical characterization of the minimal isoform of the KChIP2 potassium channel regulatory subunit.
Protein science : a publication of the Protein Society Sep, 2007 | Pubmed ID: 17660260
Beta-arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7.
Proceedings of the National Academy of Sciences of the United States of America Jan, 2010 | Pubmed ID: 20018651
Teaching old receptors new tricks: biasing seven-transmembrane receptors.
Nature reviews. Drug discovery May, 2010 | Pubmed ID: 20431569
Global phosphorylation analysis of beta-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR).
Proceedings of the National Academy of Sciences of the United States of America Aug, 2010 | Pubmed ID: 20686112
Therapeutic potential of β-arrestin- and G protein-biased agonists.
Trends in molecular medicine Mar, 2011 | Pubmed ID: 21183406
Quantifying ligand bias at seven-transmembrane receptors.
Molecular pharmacology Sep, 2011 | Pubmed ID: 21610196
Multiple ligand-specific conformations of the β2-adrenergic receptor.
Nature chemical biology Oct, 2011 | Pubmed ID: 21857662
A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1.
Nature Sep, 2011 | Pubmed ID: 21857681
Distinct phosphorylation sites on the β(2)-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin.
Science signaling Aug, 2011 | Pubmed ID: 21868357
Quantifying biased agonism: understanding the links between affinity and efficacy.
Nature reviews. Drug discovery Jun, 2013 | Pubmed ID: 23681006
Biased Agonism as a Mechanism for Differential Signaling by Chemokine Receptors.
The Journal of biological chemistry Oct, 2013 | Pubmed ID: 24145037
Right ventricular mechanics using a novel comprehensive three-view echocardiographic strain analysis in a normal population.
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography Apr, 2014 | Pubmed ID: 24508364
Comprehensive assessment of right ventricular function in patients with pulmonary hypertension with global longitudinal peak systolic strain derived from multiple right ventricular views.
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography Jun, 2014 | Pubmed ID: 24656881
Monitoring protein conformational changes and dynamics using stable-isotope labeling and mass spectrometry.
Nature protocols , 2014 | Pubmed ID: 24810039
What is biased efficacy? Defining the relationship between intrinsic efficacy and free energy coupling.
Trends in pharmacological sciences Dec, 2014 | Pubmed ID: 25448316
The influence of angle of insonation and target depth on speckle-tracking strain.
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography May, 2015 | Pubmed ID: 25655402
Use of outcome measures in pulmonary hypertension clinical trials.
American heart journal Sep, 2015 | Pubmed ID: 26385024
Safety and Tolerability of High-dose Inhaled Treprostinil in Pulmonary Hypertension.
Journal of cardiovascular pharmacology Apr, 2016 | Pubmed ID: 26828324
The β-arrestins: Multifunctional regulators of G protein-coupled receptors.
The Journal of biological chemistry Mar, 2016 | Pubmed ID: 26984408