Michael V. Norgard

DNA microarray analysis of differential gene expression in Borrelia burgdorferi, the Lyme disease spirochete.

The crystal structure of Zn(II)-free Treponema pallidum TroA, a periplasmic metal-binding protein, reveals a closed conformation.

Central nervous system infection in congenital syphilis.

Crystal structure of the 47-kDa lipoprotein of Treponema pallidum reveals a novel penicillin-binding protein.

Activation and regulation of Toll-like receptors 2 and 1 in human leprosy.

Expression of a luxS gene is not required for Borrelia burgdorferi infection of mice via needle inoculation.

Regulation of expression of the paralogous Mlp family in Borrelia burgdorferi.

The response regulator Rrp2 is essential for the expression of major membrane lipoproteins in Borrelia burgdorferi.

OspC facilitates Borrelia burgdorferi invasion of Ixodes scapularis salivary glands.

Essential role for OspA/B in the life cycle of the Lyme disease spirochete.

The Tp38 (TpMglB-2) lipoprotein binds glucose in a manner consistent with receptor function in Treponema pallidum.

The luxS gene is not required for Borrelia burgdorferi tick colonization, transmission to a mammalian host, or induction of disease.

Structural evidence that the 32-kilodalton lipoprotein (Tp32) of Treponema pallidum is an L-methionine-binding protein.

bptA (bbe16) is essential for the persistence of the Lyme disease spirochete, Borrelia burgdorferi, in its natural tick vector.

Analysis of the ospC regulatory element controlled by the RpoN-RpoS regulatory pathway in Borrelia burgdorferi.

The Lyme disease agent exploits a tick protein to infect the mammalian host.

The PnrA (Tp0319; TmpC) lipoprotein represents a new family of bacterial purine nucleoside receptor encoded within an ATP-binding cassette (ABC)-like operon in Treponema pallidum.

Characterization of Francisella tularensis outer membrane proteins.

Evidence that RpoS (sigmaS) in Borrelia burgdorferi is controlled directly by RpoN (sigma54/sigmaN).

Crystal structure of the Tp34 (TP0971) lipoprotein of treponema pallidum: implications of its metal-bound state and affinity for human lactoferrin.

Adaptation of a luciferase gene reporter and lac expression system to Borrelia burgdorferi.

Structural and biochemical basis for polyamine binding to the Tp0655 lipoprotein of Treponema pallidum: putative role for Tp0655 (TpPotD) as a polyamine receptor.

Assessment of cell-surface exposure and vaccinogenic potentials of Treponema pallidum candidate outer membrane proteins.

Effect of genital ulcer disease on HIV-1 coreceptor expression in the female genital tract.

Native outer membrane proteins protect mice against pulmonary challenge with virulent type A Francisella tularensis.

Assessment of decorin-binding protein A to the infectivity of Borrelia burgdorferi in the murine models of needle and tick infection.

Characterization of fig operon mutants of Francisella novicida U112.

Differential expression of a putative CarD-like transcriptional regulator, LtpA, in Borrelia burgdorferi.

Transcriptional interplay among the regulators Rrp2, RpoN and RpoS in Borrelia burgdorferi.

Abrogation of ospAB constitutively activates the Rrp2-RpoN-RpoS pathway (sigmaN-sigmaS cascade) in Borrelia burgdorferi.

The effect of progesterone levels and pregnancy on HIV-1 coreceptor expression.

Rrp2, a sigma54-dependent transcriptional activator of Borrelia burgdorferi, activates rpoS in an enhancer-independent manner.

A manganese transporter, BB0219 (BmtA), is required for virulence by the Lyme disease spirochete, Borrelia burgdorferi.

BosR (BB0647) governs virulence expression in Borrelia burgdorferi.

Analysis of the dbpBA upstream regulatory region controlled by RpoS in Borrelia burgdorferi.

Invariant NKT cell development requires a full complement of functional CD3 zeta immunoreceptor tyrosine-based activation motifs.

Determination of protein complex stoichiometry through multisignal sedimentation velocity experiments.

BosR (BB0647) controls the RpoN-RpoS regulatory pathway and virulence expression in Borrelia burgdorferi by a novel DNA-binding mechanism.

Cyclic di-GMP is essential for the survival of the lyme disease spirochete in ticks.

Structural, Bioinformatic, and In Vivo Analyses of Two Treponema pallidum Lipoproteins Reveal a Unique TRAP Transporter.