Departments of Microbiology & Immunology
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Peptide methionine sulfoxide reductase: structure, mechanism of action, and biological function.
Archives of biochemistry and biophysics Jan, 2002 | Pubmed ID: 11795868
Nonredundant antioxidant defense by multiple two-cysteine peroxiredoxins in human prostate cancer cells.
Molecular medicine (Cambridge, Mass.) Feb, 2002 | Pubmed ID: 12080185
Inducible nitric oxide synthase in the tuberculous human lung.
American journal of respiratory and critical care medicine Jul, 2002 | Pubmed ID: 12119220
Immunology. Catalytic antibody bridges innate and adaptive immunity.
Science (New York, N.Y.) Dec, 2002 | Pubmed ID: 12481124
Points of control in inflammation.
Nature Dec 19-26, 2002 | Pubmed ID: 12490957
Critical role of the carboxyl terminus of proline-rich tyrosine kinase (Pyk2) in the activation of human neutrophils by tumor necrosis factor: separation of signals for the respiratory burst and degranulation.
The Journal of experimental medicine Jan, 2003 | Pubmed ID: 12515814
Conversion of proepithelin to epithelins: roles of SLPI and elastase in host defense and wound repair.
Cell Dec, 2002 | Pubmed ID: 12526812
Specificity of a third kind: reactive oxygen and nitrogen intermediates in cell signaling.
The Journal of clinical investigation Mar, 2003 | Pubmed ID: 12639979
Immunology: Oxygen and the inflammatory cell.
Nature Apr, 2003 | Pubmed ID: 12700748
Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages: Insights into the Phagosomal Environment.
The Journal of experimental medicine Sep, 2003 | Pubmed ID: 12953091
MyD88 primes macrophages for full-scale activation by interferon-gamma yet mediates few responses to Mycobacterium tuberculosis.
The Journal of experimental medicine Oct, 2003 | Pubmed ID: 14517275
The proteasome of Mycobacterium tuberculosis is required for resistance to nitric oxide.
Science (New York, N.Y.) Dec, 2003 | Pubmed ID: 14671303
Identification of Mycobacterium tuberculosis counterimmune (cim) mutants in immunodeficient mice by differential screening.
Infection and immunity Sep, 2004 | Pubmed ID: 15322028
Antibiotics at the crossroads.
Nature Oct, 2004 | Pubmed ID: 15496893
The moving frontier in nitric oxide-dependent signaling.
Science's STKE : signal transduction knowledge environment Nov, 2004 | Pubmed ID: 15523044
S-nitroso proteome of Mycobacterium tuberculosis: Enzymes of intermediary metabolism and antioxidant defense.
Proceedings of the National Academy of Sciences of the United States of America Jan, 2005 | Pubmed ID: 15626759
Characterization of a Mycobacterium tuberculosis proteasomal ATPase homologue.
Molecular microbiology Jan, 2005 | Pubmed ID: 15659170
A glutamate-alanine-leucine (EAL) domain protein of Salmonella controls bacterial survival in mice, antioxidant defence and killing of macrophages: role of cyclic diGMP.
Molecular microbiology Jun, 2005 | Pubmed ID: 15882417
Mycobacterium tuberculosis and the host response.
The Journal of experimental medicine Jun, 2005 | Pubmed ID: 15939785
Variant tricarboxylic acid cycle in Mycobacterium tuberculosis: identification of alpha-ketoglutarate decarboxylase.
Proceedings of the National Academy of Sciences of the United States of America Jul, 2005 | Pubmed ID: 16027371
Role for nucleotide excision repair in virulence of Mycobacterium tuberculosis.
Infection and immunity Aug, 2005 | Pubmed ID: 16040969
Calcium-sensing soluble adenylyl cyclase mediates TNF signal transduction in human neutrophils.
The Journal of experimental medicine Aug, 2005 | Pubmed ID: 16043520
Mycobacterium tuberculosis appears to lack alpha-ketoglutarate dehydrogenase and encodes pyruvate dehydrogenase in widely separated genes.
Molecular microbiology Aug, 2005 | Pubmed ID: 16045627
Crystal structure and functional analysis of lipoamide dehydrogenase from Mycobacterium tuberculosis.
The Journal of biological chemistry Oct, 2005 | Pubmed ID: 16093239
Progress and new directions in genetics of tuberculosis: an NHLBI working group report.
American journal of respiratory and critical care medicine Dec, 2005 | Pubmed ID: 16192449
Outlook: the profit problem in antibiotic R&D.
Nature reviews. Drug discovery Nov, 2005 | Pubmed ID: 16247440
Protection from Alzheimer's-like disease in the mouse by genetic ablation of inducible nitric oxide synthase.
The Journal of experimental medicine Nov, 2005 | Pubmed ID: 16260491
Chemical inhibitors of TNF signal transduction in human neutrophils point to distinct steps in cell activation.
Journal of leukocyte biology Jan, 2006 | Pubmed ID: 16275893
Abrupt expression of TLR4 in TLR4-deficient macrophages imposes a selective disadvantage: genetic evidence for TLR4-dependent responses to endogenous, nonmicrobial stimuli.
Journal of immunology (Baltimore, Md. : 1950) Jan, 2006 | Pubmed ID: 16394008
Mycobacterium tuberculosis prcBA genes encode a gated proteasome with broad oligopeptide specificity.
Molecular microbiology Mar, 2006 | Pubmed ID: 16468985
Structure of the Mycobacterium tuberculosis proteasome and mechanism of inhibition by a peptidyl boronate.
Molecular microbiology Mar, 2006 | Pubmed ID: 16468986
Cytosolic phospholipase A2 enzymes are not required by mouse bone marrow-derived macrophages for the control of Mycobacterium tuberculosis in vitro.
Infection and immunity Mar, 2006 | Pubmed ID: 16495548
Neutrophils and immunity: challenges and opportunities.
Nature reviews. Immunology Mar, 2006 | Pubmed ID: 16498448
Role of iNOS in human host defense.
Science (New York, N.Y.) Jun, 2006 | Pubmed ID: 16809512
Man is not a mouse: reply.
Journal of leukocyte biology Mar, 2007 | Pubmed ID: 17332374
Aligning pharmaceutical innovation with medical need.
Nature medicine Mar, 2007 | Pubmed ID: 17342145
MyD88-5 links mitochondria, microtubules, and JNK3 in neurons and regulates neuronal survival.
The Journal of experimental medicine Sep, 2007 | Pubmed ID: 17724133
New approaches to filling the gap in tuberculosis drug discovery.
PLoS medicine Nov, 2007 | Pubmed ID: 17988169
Selective killing of nonreplicating mycobacteria.
Cell host & microbe Mar, 2008 | Pubmed ID: 18329613
Epidemic inflammation: pondering obesity.
Molecular medicine (Cambridge, Mass.) Jul-Aug, 2008 | Pubmed ID: 18431463
Metchnikoff's Legacy in 2008.
Nature immunology Jul, 2008 | Pubmed ID: 18563074
A membrane protein preserves intrabacterial pH in intraphagosomal Mycobacterium tuberculosis.
Nature medicine Aug, 2008 | Pubmed ID: 18641659
Identification of a copper-binding metallothionein in pathogenic mycobacteria.
Nature chemical biology Oct, 2008 | Pubmed ID: 18724363
Pulmonary nodules in an infliximab-treated rheumatoid arthritis patient: a clinical pathology conference held by the Division of Rheumatology at Hospital for Special Surgery.
HSS journal : the musculoskeletal journal of Hospital for Special Surgery Feb, 2007 | Pubmed ID: 18751782
A philosophy of anti-infectives as a guide in the search for new drugs for tuberculosis.
Tuberculosis (Edinburgh, Scotland) Aug, 2008 | Pubmed ID: 18762150
Distinct specificities of Mycobacterium tuberculosis and mammalian proteasomes for N-acetyl tripeptide substrates.
The Journal of biological chemistry Dec, 2008 | Pubmed ID: 18829465
Acid-susceptible mutants of Mycobacterium tuberculosis share hypersusceptibility to cell wall and oxidative stress and to the host environment.
Journal of bacteriology Jan, 2009 | Pubmed ID: 19011036
Microbiology. An antibiotic mimics immunity.
Science (New York, N.Y.) Nov, 2008 | Pubmed ID: 19039126
Mycobacterium tuberculosis expresses methionine sulphoxide reductases A and B that protect from killing by nitrite and hypochlorite.
Molecular microbiology Feb, 2009 | Pubmed ID: 19040639
Triterpenoid CDDO-methylamide improves memory and decreases amyloid plaques in a transgenic mouse model of Alzheimer's disease.
Journal of neurochemistry Apr, 2009 | Pubmed ID: 19200343
Taming tuberculosis: a challenge for science and society.
Cell host & microbe Mar, 2009 | Pubmed ID: 19286131
Acid resistance in Mycobacterium tuberculosis.
Journal of bacteriology Aug, 2009 | Pubmed ID: 19465648
Nitazoxanide kills replicating and nonreplicating Mycobacterium tuberculosis and evades resistance.
Journal of medicinal chemistry Oct, 2009 | Pubmed ID: 19736929
Inhibitors selective for mycobacterial versus human proteasomes.
Nature Oct, 2009 | Pubmed ID: 19759536
Structural insights on the Mycobacterium tuberculosis proteasomal ATPase Mpa.
Structure (London, England : 1993) Oct, 2009 | Pubmed ID: 19836337
N-iminoethyl-L-lysine improves memory and reduces amyloid pathology in a transgenic mouse model of amyloid deposition.
Neurochemistry international Jan, 2010 | Pubmed ID: 19914323
Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice.
The Journal of experimental medicine Jan, 2010 | Pubmed ID: 20026663
Triazaspirodimethoxybenzoyls as selective inhibitors of mycobacterial lipoamide dehydrogenase .
Biochemistry Mar, 2010 | Pubmed ID: 20078138
Nonresolving inflammation.
Cell Mar, 2010 | Pubmed ID: 20303877
SnapShot: Reactive Oxygen Intermediates (ROI).
Cell Mar, 2010 | Pubmed ID: 20303882
Activity-based metabolomic profiling of enzymatic function: identification of Rv1248c as a mycobacterial 2-hydroxy-3-oxoadipate synthase.
Chemistry & biology Apr, 2010 | Pubmed ID: 20416504
Killing of non-replicating Mycobacterium tuberculosis by 8-hydroxyquinoline.
The Journal of antimicrobial chemotherapy Jul, 2010 | Pubmed ID: 20435781
Fellutamide B is a potent inhibitor of the Mycobacterium tuberculosis proteasome.
Archives of biochemistry and biophysics Sep, 2010 | Pubmed ID: 20558127
Behavioral deficits and progressive neuropathology in progranulin-deficient mice: a mouse model of frontotemporal dementia.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Dec, 2010 | Pubmed ID: 20667979
Induction of ER stress in macrophages of tuberculosis granulomas.
PloS one Sep, 2010 | Pubmed ID: 20856677
A protecting group-free synthesis of deazathiamine: a step toward inhibitor design.
Bioorganic & medicinal chemistry letters Nov, 2010 | Pubmed ID: 20943392
Metabolomics of Mycobacterium tuberculosis reveals compartmentalized co-catabolism of carbon substrates.
Chemistry & biology Oct, 2010 | Pubmed ID: 21035735
Genome-wide screen for Mycobacterium tuberculosis genes that regulate host immunity.
PloS one Dec, 2010 | Pubmed ID: 21170273
Identification of a chemical that inhibits the mycobacterial UvrABC complex in nucleotide excision repair.
Biochemistry Mar, 2011 | Pubmed ID: 21235228
Virulence of Mycobacterium tuberculosis depends on lipoamide dehydrogenase, a member of three multienzyme complexes.
Cell host & microbe Jan, 2011 | Pubmed ID: 21238944
Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier.
Trends in microbiology Jul, 2011 | Pubmed ID: 21561773
Making space for anti-infective drug discovery.
Cell host & microbe May, 2011 | Pubmed ID: 21575903
Identification of new inhibitors of protein kinase R guided by statistical modeling.
Bioorganic & medicinal chemistry letters Jul, 2011 | Pubmed ID: 21632247
Mycobacterium tuberculosis gene Rv2136c is dispensable for acid resistance and virulence in mice.
Tuberculosis (Edinburgh, Scotland) Sep, 2011 | Pubmed ID: 21778115
In vitro differentiation of human macrophages with enhanced antimycobacterial activity.
The Journal of clinical investigation Oct, 2011 | Pubmed ID: 21911939
Is iNOS beginning to smoke?
Cell Oct, 2011 | Pubmed ID: 22000003
Nitazoxanide Disrupts Membrane Potential and Intrabacterial pH Homeostasis of Mycobacterium tuberculosis.
ACS medicinal chemistry letters , 2011 | Pubmed ID: 22096616
Remembering Ralph Steinman.
The Journal of experimental medicine Nov, 2011 | Pubmed ID: 22216461
Improved control of tuberculosis and activation of macrophages in mice lacking protein kinase R.
PloS one , 2012 | Pubmed ID: 22359543
Secretory products of macrophages: twenty-five years on.
The Journal of clinical investigation Apr, 2012 | Pubmed ID: 22570864
dSarm/Sarm1 is required for activation of an injury-induced axon death pathway.
Science (New York, N.Y.) Jul, 2012 | Pubmed ID: 22678360
Fresh approaches to anti-infective therapies.
Science translational medicine Jun, 2012 | Pubmed ID: 22745440
Nonsteroidal anti-inflammatory drug sensitizes Mycobacterium tuberculosis to endogenous and exogenous antimicrobials.
Proceedings of the National Academy of Sciences of the United States of America Oct, 2012 | Pubmed ID: 23012453
Efficacy of nitazoxanide against clinical isolates of Mycobacterium tuberculosis.
Antimicrobial agents and chemotherapy Jun, 2013 | Pubmed ID: 23507275
Beyond oxidative stress: an immunologist's guide to reactive oxygen species.
Nature reviews. Immunology May, 2013 | Pubmed ID: 23618831
SARM Is Required for Neuronal Injury and Cytokine Production in Response to Central Nervous System Viral Infection.
Journal of immunology (Baltimore, Md. : 1950) Jun, 2013 | Pubmed ID: 23749635
Influence of allosteric regulators on individual steps in the reaction catalyzed by Mycobacterium tuberculosis 2-hydroxy-3-oxoadipate synthase.
The Journal of biological chemistry Jul, 2013 | Pubmed ID: 23760263
N,C-Capped dipeptides with selectivity for mycobacterial proteasome over human proteasomes: role of S3 and S1 binding pockets.
Journal of the American Chemical Society Jul, 2013 | Pubmed ID: 23782398
Whole cell screen for inhibitors of pH homeostasis in Mycobacterium tuberculosis.
PloS one , 2013 | Pubmed ID: 23935911
Nitrite impacts the survival of Mycobacterium tuberculosis in response to isoniazid and hydrogen peroxide.
MicrobiologyOpen Dec, 2013 | Pubmed ID: 24019302
A journey in science: promise, purpose, privilege.
Molecular medicine (Cambridge, Mass.) Oct, 2013 | Pubmed ID: 24089245
Perspective: Graduation time.
Nature Oct, 2013 | Pubmed ID: 24108080
Nitrite produced by Mycobacterium tuberculosis in human macrophages in physiologic oxygen impacts bacterial ATP consumption and gene expression.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2013 | Pubmed ID: 24145454
Genetic regulation of vesiculogenesis and immunomodulation in Mycobacterium tuberculosis.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2013 | Pubmed ID: 24248369
Lipoamide channel-binding sulfonamides selectively inhibit mycobacterial lipoamide dehydrogenase.
Biochemistry Dec, 2013 | Pubmed ID: 24251446
Drug-resistant tuberculosis: a new shot on goal.
Nature medicine Feb, 2014 | Pubmed ID: 24504402
Benzimidazole-based compounds kill Mycobacterium tuberculosis.
European journal of medicinal chemistry Mar, 2014 | Pubmed ID: 24556148
Synthetic calanolides with bactericidal activity against replicating and nonreplicating Mycobacterium tuberculosis.
Journal of medicinal chemistry May, 2014 | Pubmed ID: 24694175
Oxathiazolones Selectively Inhibit the Human Immunoproteasome over the Constitutive Proteasome.
ACS medicinal chemistry letters Apr, 2014 | Pubmed ID: 24900849
Isocitrate lyase mediates broad antibiotic tolerance in Mycobacterium tuberculosis.
Nature communications Jun, 2014 | Pubmed ID: 24978671
Antibiotic resistance--problems, progress, and prospects.
The New England journal of medicine Nov, 2014 | Pubmed ID: 25271470
Target-based screen against a periplasmic serine protease that regulates intrabacterial pH homeostasis in Mycobacterium tuberculosis.
ACS chemical biology Feb, 2015 | Pubmed ID: 25457457
Stressed mycobacteria use the chaperone ClpB to sequester irreversibly oxidized proteins asymmetrically within and between cells.
Cell host & microbe Feb, 2015 | Pubmed ID: 25620549
Video podcast: Tuberculosis.
Immunological reviews Mar, 2015 | Pubmed ID: 25703547
What can immunology contribute to the control of the world's leading cause of death from bacterial infection?
Immunological reviews Mar, 2015 | Pubmed ID: 25703548
TB drug development: immunology at the table.
Immunological reviews Mar, 2015 | Pubmed ID: 25703568
A multi-stress model for high throughput screening against non-replicating Mycobacterium tuberculosis.
Methods in molecular biology (Clifton, N.J.) , 2015 | Pubmed ID: 25779324
Identification of Rv3852 as an Agrimophol-Binding Protein in Mycobacterium tuberculosis.
PloS one , 2015 | Pubmed ID: 25978362
Rapid, Semiquantitative Assay To Discriminate among Compounds with Activity against Replicating or Nonreplicating Mycobacterium tuberculosis.
Antimicrobial agents and chemotherapy Oct, 2015 | Pubmed ID: 26239979
Cooperative development of antimicrobials: looking back to look ahead.
Nature reviews. Microbiology Oct, 2015 | Pubmed ID: 26373373
E1 of α-ketoglutarate dehydrogenase defends Mycobacterium tuberculosis against glutamate anaplerosis and nitroxidative stress.
Proceedings of the National Academy of Sciences of the United States of America Oct, 2015 | Pubmed ID: 26430237
IMMUNOLOGY. From transient infection to chronic disease.
Science (New York, N.Y.) Oct, 2015 | Pubmed ID: 26450196
Comparison of transposon and deletion mutants in Mycobacterium tuberculosis: The case of rv1248c, encoding 2-hydroxy-3-oxoadipate synthase.
Tuberculosis (Edinburgh, Scotland) Dec, 2015 | Pubmed ID: 26547230
Human studies at JEM: Immunology and beyond.
The Journal of experimental medicine Apr, 2016 | Pubmed ID: 26976629
Novel Cephalosporins Selectively Active on Nonreplicating Mycobacterium tuberculosis.
Journal of medicinal chemistry Jul, 2016 | Pubmed ID: 27144688
N-methylation of a bactericidal compound as a resistance mechanism in Mycobacterium tuberculosis.
Proceedings of the National Academy of Sciences of the United States of America Aug, 2016 | Pubmed ID: 27432954
Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.
PLoS pathogens Jul, 2016 | Pubmed ID: 27467575
Immunoproteasome β5i-Selective Dipeptidomimetic Inhibitors.
ChemMedChem Oct, 2016 | Pubmed ID: 27561172
Identification of Novel Anti-mycobacterial Compounds by Screening a Pharmaceutical Small-Molecule Library against Nonreplicating Mycobacterium tuberculosis.
ACS infectious diseases Dec, 2015 | Pubmed ID: 27623055
Macrophages' Choice: Take It In or Keep It Out.
Immunity Oct, 2016 | Pubmed ID: 27760333
Reconstitution of a Mycobacterium tuberculosis proteostasis network highlights essential cofactor interactions with chaperone DnaK.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2016 | Pubmed ID: 27872278
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