Douglas A. Melton

Pancreatic lineage analysis using a retroviral vector in embryonic mice demonstrates a common progenitor for endocrine and exocrine cells.

Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors.

Functional genomics of the endocrine pancreas: the pancreas clone set and PancChip, new resources for diabetes research.

"Stemness": transcriptional profiling of embryonic and adult stem cells.

Direct lineage tracing reveals the ontogeny of pancreatic cell fates during mouse embryogenesis.

Insulin staining of ES cell progeny from insulin uptake.

Single-cell transcript analysis of pancreas development.

Endothelial signaling during development.

Role of VEGF-A in vascularization of pancreatic islets.

Genes, signals, and lineages in pancreas development.

Notch signaling controls multiple steps of pancreatic differentiation.

Global expression analysis of gene regulatory pathways during endocrine pancreatic development.

Derivation of embryonic stem-cell lines from human blastocysts.

Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation.

The Src family of tyrosine kinases is important for embryonic stem cell self-renewal.

How important are adult stem cells for tissue maintenance?

Altered nuclear transfer in stem-cell research - a flawed proposal.

The molecular biography of the cell.

Direct regulation of intestinal fate by Notch.

Nuclear reprogramming of somatic cells after fusion with human embryonic stem cells.

Core transcriptional regulatory circuitry in human embryonic stem cells.

Pten constrains centroacinar cell expansion and malignant transformation in the pancreas.

Beta-catenin is essential for pancreatic acinar but not islet development.

The vascular basement membrane: a niche for insulin gene expression and Beta cell proliferation.

Control of developmental regulators by Polycomb in human embryonic stem cells.

Reversal of type 1 diabetes in mice.

Notch signaling reveals developmental plasticity of Pax4(+) pancreatic endocrine progenitors and shunts them to a duct fate.

Organ size is limited by the number of embryonic progenitor cells in the pancreas but not the liver.

Prospective isolation and global gene expression analysis of definitive and visceral endoderm.

A multipotent progenitor domain guides pancreatic organogenesis.

Recovery from diabetes in mice by beta cell regeneration.

A gene regulatory network in mouse embryonic stem cells.

Genetic targeting of the endoderm with claudin-6CreER.

Facultative endocrine progenitor cells in the adult pancreas.

Marked differences in differentiation propensity among human embryonic stem cell lines.

Wnt7b stimulates embryonic lung growth by coordinately increasing the replication of epithelium and mesenchyme.

Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds.

In vivo reprogramming of adult pancreatic exocrine cells to beta-cells.

Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2.

Extreme makeover: converting one cell into another.

Transcriptional dynamics of endodermal organ formation.

Optimal timing of inner cell mass isolation increases the efficiency of human embryonic stem cell derivation and allows generation of sibling cell lines.

Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells.

Notch signaling promotes airway mucous metaplasia and inhibits alveolar development.

Generation of pluripotent stem cells from patients with type 1 diabetes.

How to make beta cells?

Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal.

Wnt signaling specifies and patterns intestinal endoderm.

Reprogramming within hours following nuclear transfer into mouse but not human zygotes.

Impracticality of egg donor recruitment in the absence of compensation.