Ke Ren

Inflammatory Models of Pain and Hyperalgesia.

Plasticity in excitatory amino acid receptor-mediated descending pain modulation after inflammation.

Age-dependency of analgesia elicited by intraoral sucrose in acute and persistent pain models.

Tyrosine phosphorylation of the NR2B subunit of the NMDA receptor in the spinal cord during the development and maintenance of inflammatory hyperalgesia.

Activation of spinal kainate receptors after inflammation: behavioral hyperalgesia and subunit gene expression.

Descending modulation in persistent pain: an update.

Proton transfer within the active-site cavity of carbonic anhydrase III.

Inflammation-induced upregulation of AMPA receptor subunit expression in brain stem pain modulatory circuitry.

Swan-shaped bone fixation device made of Ni-Ti shape memory alloy for treating humeral fracture in rabbits.

Differential rostral projections of caudal brainstem neurons receiving trigeminal input after masseter inflammation.

The medulla oblongata: the vital center for descending modulation.

Trigeminal neuronal recording in animal models of orofacial pain.

Changes in AMPA receptor phosphorylation in the rostral ventromedial medulla after inflammatory hyperalgesia in rats.

Electroacupuncture combined with indomethacin enhances antihyperalgesia in inflammatory rats.

Involvement of opioid receptors in electroacupuncture-produced anti-hyperalgesia in rats with peripheral inflammation.

A parametric study of electroacupuncture on persistent hyperalgesia and Fos protein expression in rats.

Alteration of the second branch of the trigeminal nerve activity following inferior alveolar nerve transection in rats.

Group I metabotropic glutamate receptor NMDA receptor coupling and signaling cascade mediate spinal dorsal horn NMDA receptor 2B tyrosine phosphorylation associated with inflammatory hyperalgesia.

Cultured cell and transgenic mouse models for tau pathology linked to beta-amyloid.

Central neuronal changes after nerve injury: neuroplastic influences of injury and aging.

Brainstem mechanisms of persistent pain following injury.

Effect of chronic inflammation on dorsal horn nociceptive neurons in aged rats.

Electroacupuncture attenuates inflammation in a rat model.

[Noninvasive image diagnosis of Budd-Chiari syndrome and its evaluation study].

Effects of pertussis toxin on electroacupuncture-produced anti-hyperalgesia in inflamed rats.

Electroacupuncture combined with MK-801 prolongs anti-hyperalgesia in rats with peripheral inflammation.

Electroacupuncture suppresses spinal expression of neurokinin-1 receptors induced by persistent inflammation in rats.

Antibody array analysis of peripheral and blood cytokine levels in rats after masseter inflammation.

Mu opioid receptor-containing neurons mediate electroacupuncture-produced anti-hyperalgesia in rats with hind paw inflammation.

Multiple calcium channels and kinases mediate alpha7 nicotinic receptor neuroprotection in PC12 cells.

Activation of trigeminal intranuclear pathway in rats with temporomandibular joint inflammation.

Spinal glial activation in a new rat model of bone cancer pain produced by prostate cancer cell inoculation of the tibia.

Neonatal local noxious insult affects gene expression in the spinal dorsal horn of adult rats.

Involvement of dorsal column nucleus neurons in nociceptive transmission in aged rats.

Trigeminal transition zone/rostral ventromedial medulla connections and facilitation of orofacial hyperalgesia after masseter inflammation in rats.

Supraspinal brain-derived neurotrophic factor signaling: a novel mechanism for descending pain facilitation.

Phosphorylation of Extracellular Signal-Regulated Kinase in medullary and upper cervical cord neurons following noxious tooth pulp stimulation.

Demonstration of a trigeminothalamic pathway to the oval paracentral intralaminar thalamic nucleus and its involvement in the processing of noxious orofacial deep inputs.

Involvement of peripheral opioid mechanisms in electroacupuncture analgesia.

Differential responses of rostral subnucleus caudalis and upper cervical dorsal horn neurons to mechanical and chemical stimulation of the parotid gland in rats.

Selective distribution and function of primary afferent nociceptive inputs from deep muscle tissue to the brainstem trigeminal transition zone.

Anti-hyperalgesic and anti-inflammatory effects of the modified Chinese herbal formula Huo Luo Xiao Ling Dan (HLXL) in rats.

Reversal of agonist selectivity by mutations of conserved amino acids in the binding site of nicotinic acetylcholine receptors.

Recent advances in basic neurosciences and brain disease: from synapses to behavior.

Application and evaluation of non-invasive examination for Budd-Chiari syndrome.

Preliminary evaluation of magnetic resonance fresh blood imaging for diagnosis of Budd-Chiari syndrome.

Brain-derived neurotrophic factor prevents the nigrostriatal degeneration induced by human immunodeficiency virus-1 glycoprotein 120 in vivo.

Interleukin-1ra inhibits Fos expression and hyperalgesia in rats.

Glial-cytokine-neuronal interactions underlying the mechanisms of persistent pain.

[The research on the mechanism of Pim-2 suppressing the apoptosis of tumor cell].

IL-1ra alleviates inflammatory hyperalgesia through preventing phosphorylation of NMDA receptor NR-1 subunit in rats.

Corticosterone mediates electroacupuncture-produced anti-edema in a rat model of inflammation.

Pain facilitation and activity-dependent plasticity in pain modulatory circuitry: role of BDNF-TrkB signaling and NMDA receptors.

Electroacupuncture attenuates bone cancer pain and inhibits spinal interleukin-1 beta expression in a rat model.

Electroacupuncture suppresses hyperalgesia and spinal Fos expression by activating the descending inhibitory system.

Brain-derived neurotrophic factor prevents human immunodeficiency virus type 1 protein gp120 neurotoxicity in the rat nigrostriatal system.

Electroacupuncture attenuates bone-cancer-induced hyperalgesia and inhibits spinal preprodynorphin expression in a rat model.

Modulation of spontaneous hippocampal synaptic events with 5-hydroxyindole, 4OH-GTS-21, and rAAV-mediated alpha7 nicotinic receptor gene transfer.

Electroacupuncture activates corticotrophin-releasing hormone-containing neurons in the paraventricular nucleus of the hypothalammus to alleviate edema in a rat model of inflammation.

Serine/threonine kinase Pim-2 promotes liver tumorigenesis induction through mediating survival and preventing apoptosis of liver cell.

Modulation of paratrigeminal nociceptive neurons following temporomandibular joint inflammation in rats.

Neuron-glia crosstalk gets serious: role in pain hypersensitivity.

Supraspinal glial-neuronal interactions contribute to descending pain facilitation.

Role of interleukin-1beta during pain and inflammation.

[Effects of Swan-like Shape Memory Connector on stress shielding rate and callus development during experimental fracture healing process].

Increased phosphorylation of extracellular signal-regulated kinase in trigeminal nociceptive neurons following propofol administration in rats.

[Preparation, identification and thermodynamic stability of capsaicin-hydroxypropyl-beta-cyclodextrin inclusion compound].

Self-nanoemulsifying drug delivery system (SNEDDS) for oral delivery of Zedoary essential oil: formulation and bioavailability studies.

Physicochemical characteristics and oral bioavailability of andrographolide complexed with hydroxypropyl-beta-cyclodextrin.

Pim-2 activates API-5 to inhibit the apoptosis of hepatocellular carcinoma cells through NF-kappaB pathway.

Differential involvement of trigeminal transition zone and laminated subnucleus caudalis in orofacial deep and cutaneous hyperalgesia: the effects of interleukin-10 and glial inhibitors.

Lipid nanoparticles loaded with 10-hydroxycamptothecin-phospholipid complex developed for the treatment of hepatoma in clinical application.

Emerging role of astroglia in pain hypersensitivity.

[Hath1 gene transfer inhibits the proliferation of colonic cancer cells in vitro].

Dual Roles for Endothelin-B Receptors in Modulating Adjuvant-Induced Inflammatory Hyperalgesia in Rats.

Molecular depletion of descending serotonin unmasks its novel facilitatory role in the development of persistent pain.

Ectopic over-expression of oncogene Pim-2 induce malignant transformation of nontumorous human liver cell line L02.

Long lasting pain hypersensitivity following ligation of the tendon of the masseter muscle in rats: a model of myogenic orofacial pain.

Inhibition of class II histone deacetylases in the spinal cord attenuates inflammatory hyperalgesia.

Interactions between the immune and nervous systems in pain.

Enhanced aqueous solubility and bioavailability of capsaicin by the preparation of an inclusion complex.

Neuron, Glia and Reciprocal Relationships in Pain Processing.

Early detection and treatment of wear particle-induced inflammation and bone loss in a mouse calvarial osteolysis model using HPMA copolymer conjugates.

Involvement of spinal serotonin receptors in electroacupuncture anti-hyperalgesia in an inflammatory pain rat model.

Rostral ventromedial medulla μ, but not κ, opioid receptors are involved in electroacupuncture anti-hyperalgesia in an inflammatory pain rat model.

[The operative treatment of Ruedi II-III Pilon fractures with the ventr-lateral approach].

Bone marrow stromal cells produce long-term pain relief in rat models of persistent pain.

Acupuncture alleviates the affective dimension of pain in a rat model of inflammatory hyperalgesia.

The role of trigeminal interpolaris-caudalis transition zone in persistent orofacial pain.

Serotonin Receptor 2A/C Is Involved in Electroacupuncture Inhibition of Pain in an Osteoarthritis Rat Model.

The effects of opioid receptor antagonists on electroacupuncture-produced anti-allodynia/hyperalgesia in rats with paclitaxel-evoked peripheral neuropathy.

Spinal 5-HT(3) receptor activation induces behavioral hypersensitivity via a neuronal-glial-neuronal signaling cascade.

Activation of group I mGlu receptors contributes to facilitation of NMDA receptor membrane current in spinal dorsal horn neurons after hind paw inflammation in rats.

Common deficiencies with bioequivalence submissions in abbreviated new drug applications assessed by FDA.

[A clinical study of pituitrin versus norepinephrine in the treatment of patients with septic shock].

Laparoscopic radical cystectomy for bladder cancer with prostatic and neurovascular sparing: initial experience.

Primary clavicle tumors and tumorous lesions: a review of 206 cases in East Asia.

[Clinical manifestation and strategy for surgical resection and reconstruction of thoracolumbar vertebral osteoid osteoma].

Chemokine signaling involving chemokine (C-C motif) ligand 2 plays a role in descending pain facilitation.

Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors.

Further evidence on a role of chemokines in injury-related pain hypersensitivity: commentary on a paper by Saika et al. (2012, this issue).

Trigeminal-rostral ventromedial medulla circuitry is involved in orofacial hyperalgesia contralateral to tissue injury.

RADIATION DOSE STUDY OF 64-SLICE SPIRAL CT CORONARY ANGIOGRAPHY: A PAIRED DESIGN.

Spinal interleukin-17 promotes thermal hyperalgesia and NMDA NR1 phosphorylation in an inflammatory pain rat model.

PrP octarepeats region determined the interaction with caveolin-1 and phosphorylation of caveolin-1 and Fyn.

[Value of multidetector CT on aiding intraoperative judgement of serosal invasion of gastric cancer].

Hath1 inhibits proliferation of colon cancer cells probably through up-regulating expression of Muc2 and p27 and down-regulating expression of cyclin D1.

Transition to persistent orofacial pain after nerve injury involves supraspinal serotonin mechanisms.

[Mutant D178N prion protein converts spontaneously in RT-QuIC assay].

Flotillin-1 mediates PrPc endocytosis in the cultured cells during Cu²⁺ stimulation through molecular interaction.

Abortive cell cycle events in the brains of scrapie-infected hamsters with remarkable decreases of PLK3/Cdc25C and increases of PLK1/cyclin B1.

[Study on the correlation between membrane protein Flotillin-1 and PrPc endocytosis].

[Analysis of the expressions of alphaB-crystallin in the brain tissues of agent 263K-infected hamsters at terminal stage].

The over-expression of Pim-2 promote the tumorigenesis of prostatic carcinoma through phosphorylating eIF4B.

Brain microglia were activated in sporadic CJD but almost unchanged in fatal familial insomnia and G114V genetic CJD.

Mouse lymphatic endothelial cell targeted probes: anti-LYVE-1 antibody-based magnetic nanoparticles.

Abnormally upregulated αB-crystallin was highly coincidental with the astrogliosis in the brains of scrapie-infected hamsters and human patients with prion diseases.

Celastrol protects kidney against ischemia-reperfusion-induced injury in rats.

Development of inclusion complex of brinzolamide with hydroxypropyl-β-cyclodextrin.

Overexpression of p62/SQSTM1 promotes the degradations of abnormally accumulated PrP mutants in cytoplasm and relieves the associated cytotoxicities via autophagy-lysosome-dependent way.

Significant reduction of the GLUT3 level, but not GLUT1 level, was observed in the brain tissues of several scrapie experimental animals and scrapie-infected cell lines.

Mechanisms of acupuncture-electroacupuncture on persistent pain.

Macromolecular prodrug of dexamethasone prevents particle-induced peri-implant osteolysis with reduced systemic side effects.

Induction of bone loss in DBA/1J mice immunized with citrullinated autologous mouse type II collagen in the absence of adjuvant.

Disruption of glycosylation enhances ubiquitin-mediated proteasomal degradation of Shadoo in Scrapie-infected rodents and cultured cells.

Development of polymeric nanocarrier system for early detection and targeted therapeutic treatment of peri-implant osteolysis.

Central terminal sensitization of TRPV1 by descending serotonergic facilitation modulates chronic pain.

Dual agent loaded PLGA nanoparticles enhanced antitumor activity in a multidrug-resistant breast tumor eenograft model.

Development of lipid-shell and polymer core nanoparticles with water-soluble salidroside for anti-cancer therapy.

Early diagnosis of orthopedic implant failure using macromolecular imaging agents.

Multipotent stromal cells for arthritic joint pain therapy and beyond.

Apparent reduction of ADAM10 in scrapie-infected cultured cells and in the brains of scrapie-infected rodents.

Study on biopharmaceutics classification and oral bioavailability of a novel multikinase inhibitor NCE for cancer therapy.

Radiology-guided forceps biopsy and airway stenting in severe airway stenosis.

Remarkable reductions of PAKs in the brain tissues of scrapie-infected rodent possibly linked closely with neuron loss.

Primary osseous hemangiopericytoma in the thoracic spine.

Spinal 5-HT3 receptors mediate descending facilitation and contribute to behavioral hypersensitivity via a reciprocal neuron-glial signaling cascade.

Epigenetic regulation of persistent pain.

Effects of transplantation with marrow-derived mesenchymal stem cells modified with survivin on renal ischemia-reperfusion injury in mice.

Vasculogenic mimicry: a new prognostic sign of human osteosarcoma.

Effects of iodinated contrast agents on renal oxygenation level determined by blood oxygenation level dependent magnetic resonance imaging in rabbit models of type 1 and type 2 diabetic nephropathy.

PD806: a novel oral vascular disrupting agent shows antitumor and antivascular effects in vitro and in vivo.

In reply.

Identification of primary thyroid lymphoma with medical imaging: A case report and review of the literature.

α, ω-Cholesterol-functionalized low molecular weight polyethylene glycol as a novel modifier of cationic liposomes for gene delivery.

Simvastatin prodrug micelles target fracture and improve healing.

FBXW7-Induced MTOR Degradation Forces Autophagy to Counteract Persistent Prion Infection.

Gliotoxin potentiates osteoblast differentiation by inhibiting nuclear factor-κB signaling.

Macromolecular glucocorticoid prodrug improves the treatment of dextran sulfate sodium-induced mice ulcerative colitis.

The primary study of low-dose pancreas perfusion by 640- slice helical CT: a whole-organ perfusion.

Combretastatin A4 phosphate treatment induces vasculogenic mimicry formation of W256 breast carcinoma tumor in vitro and in vivo.

Novel quinazoline derivatives exhibit antitumor activity by inhibiting JAK2/STAT3.

The Evaluation of the Therapeutic Efficacy and Side Effects of a Macromolecular Dexamethasone Prodrug in the Collagen-Induced Arthritis Mouse Model.

Liposomes as a Novel Ocular Delivery System for Brinzolamide: In Vitro and In Vivo Studies.

Focal adhesion kinase overexpression and its impact on human osteosarcoma.

Activation of the AMPK-ULK1 pathway plays an important role in autophagy during prion infection.

Activity-triggered tetrapartite neuron-glial interactions following peripheral injury.

Surface Thiolation of Al Microspheres to Deposite Thin and Compact Ag Shells for High Conductivity.

ROS activates JNK-mediated autophagy to counteract apoptosis in mouse mesenchymal stem cells in vitro.

Polymeric Nanomedicine for Combined Gene/chemo-therapy Elicits Enhanced Tumor Suppression.

Pigment epithelial-derived factor gene loaded novel COOH-PEG-PLGA-COOH nanoparticles promoted tumor suppression by systemic administration.

The Evaluation of Therapeutic Efficacy and Safety Profile of Simvastatin Prodrug Micelles in a Closed Fracture Mouse Model.

Suppression of IRG-1 Reduces Inflammatory Cell Infiltration and Lung Injury in Respiratory Syncytial Virus Infection by Reducing Production of Reactive Oxygen Species.

Further observations on the behavioral and neural effects of bone marrow stromal cells in rodent pain models.

Correction: Yan Chen, et al. Dual Agent Loaded PLGA Nanoparticles Enhanced Antitumor Activity in a Multidrug-Resistant Breast Tumor Eenograft Model. Int. J. Mol. Sci. 2014, 15, 2761-2772.

An Epigenetic Compound Library Screen Identifies BET Inhibitors That Promote HSV-1 and -2 Replication by Bridging P-TEFb to Viral Gene Promoters through BRD4.

Baicalin from Scutellaria baicalensis blocks respiratory syncytial virus (RSV) infection and reduces inflammatory cell infiltration and lung injury in mice.

Application of BOLD MRI and DTI for the evaluation of renal effect related to viscosity of iodinated contrast agent in a rat model.

Spectral computed tomography in advanced gastric cancer: Can iodine concentration non-invasively assess angiogenesis?

Paris polyphylla Suppresses Proliferation and Vasculogenic Mimicry of Human Osteosarcoma Cells and Inhibits Tumor Growth In Vivo.

Engineering bone regeneration with novel cell-laden hydrogel microfiber-injectable calcium phosphate scaffold.

Electrospun PCL/gelatin composite nanofiber structures for effective guided bone regeneration membranes.