Dagmar Wirth

Green fluorescent protein-tagged retroviral envelope protein for analysis of virus-cell interactions.

Stable and strictly controlled expression of LTR-flanked autoregulated expression cassettes upon adenoviral transfer.

Flp-mediated integration of expression cassettes into FRT-tagged chromosomal loci in mammalian cells.

Interleukin-6 is a direct mediator of T cell migration.

Transcriptional control of SV40 T-antigen expression allows a complete reversion of immortalization.

Transcriptionally regulated immortalization overcomes side effects of temperature-sensitive SV40 large T antigen.

Simultaneous blockade of NFkappaB, JNK, and p38 MAPK by a kinase-inactive mutant of the protein kinase TAK1 sensitizes cells to apoptosis and affects a distinct spectrum of tumor necrosis factor [corrected] target genes.

Establishment of murine cell lines by constitutive and conditional immortalization.

Epigenetic silencing and tissue independent expression of a novel tetracycline inducible system in double-transgenic pigs.

A new generation of retroviral producer cells: predictable and stable virus production by Flp-mediated site-specific integration of retroviral vectors.

Health status of transgenic pigs expressing the human complement regulatory protein CD59.

Road to precision: recombinase-based targeting technologies for genome engineering.

In vitro expansion of tissue cells by conditional proliferation.

Bimodal and hysteretic expression in mammalian cells from a synthetic gene circuit.

Current status of transcriptional regulation systems.

Application of a reversible immortalization system for the generation of proliferation-controlled cell lines.

Synthetic gene regulation circuits for control of cell expansion.

Precise regulation of transgene expression level and control of cell physiology.

Recombinant protein expression by targeting pre-selected chromosomal loci.

Integrated strategy for the production of therapeutic retroviral vectors.

Rapid establishment of G-protein-coupled receptor-expressing cell lines by site-specific integration.

Lentivirus production is influenced by SV40 large T-antigen and chromosomal integration of the vector in HEK293 cells.

Manufacturing of retroviruses.

Deletion of Kaposi's sarcoma-associated herpesvirus FLICE inhibitory protein, vFLIP, from the viral genome compromises the activation of STAT1-responsive cellular genes and spindle cell formation in endothelial cells.

Streamlining homogeneous glycoprotein production for biophysical and structural applications by targeted cell line development.

Towards rational engineering of cells: Recombinant gene expression in defined chromosomal loci.

The ROSA26-iPSC mouse: a conditional, inducible, and exchangeable resource for studying cellular (De)differentiation.

A new reporter mouse cytomegalovirus reveals maintained immediate-early gene expression but poor virus replication in cycling liver sinusoidal endothelial cells.

Eternity and functionality - rational access to physiologically relevant cell lines.

An inducible transgenic mouse model for immune mediated hepatitis showing clearance of antigen expressing hepatocytes by CD8+ T cells.

Efficient ROSA26-based conditional and/or inducible transgenesis using RMCE-compatible F1 hybrid mouse embryonic stem cells.

Reversible silencing of cytomegalovirus genomes by type I interferon governs virus latency.

Uncoupling of the dynamics of host-pathogen interaction uncovers new mechanisms of viral interferon antagonism at the single-cell level.

Stability of single copy transgene expression in CHOK1 cells is affected by histone modifications but not by DNA methylation.

Single-cell analysis reveals heterogeneity in onset of transgene expression from synthetic tetracycline-dependent promoters.

A permanently growing human endothelial cell line supports productive infection with human cytomegalovirus under conditional cell growth arrest.

Effective intrahepatic CD8+ T-cell immune responses are induced by low but not high numbers of antigen-expressing hepatocytes.

Evidence that hepatitis B virus replication in mouse cells is limited by the lack of a host cell dependency factor.

Impaired antiviral response of adenovirus-transformed cell lines supports virus replication.

Extracellular-signal regulated kinase (Erk1/2), mitogen-activated protein kinase-activated protein kinase 2 (MK2) and tristetraprolin (TTP) comprehensively regulate injury-induced immediate early gene (IEG) response in in vitro liver organ culture.

Human alveolar epithelial cells expressing tight junctions to model the air-blood barrier.

Evaluation of the inflammatory potential of implant materials in a mouse model by bioluminescent imaging of intravenously injected bone marrow cells.

p120 Catenin-Mediated Stabilization of E-Cadherin Is Essential for Primitive Endoderm Specification.

Epigenetic modulations rendering cell-to-cell variability and phenotypic metastability.

Proliferation status defines functional properties of endothelial cells.

Diet induced obesity has an influence on intrahepatic T cell responses.