Rodrigo A. Cunha

Long-term effect of convulsive behavior on the density of adenosine A1 and A 2A receptors in the rat cerebral cortex.

Modulation of the rat hippocampal dinucleotide receptor by adenosine receptor activation.

Effects of carbamazepine and novel 10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide derivatives on synaptic transmission in rat hippocampal slices.

Transducing system operated by adenosine A(2A) receptors to facilitate acetylcholine release in the rat hippocampus.

Solubilization and immunological identification of presynaptic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors in the rat hippocampus.

Pharmacology of adenosine A2A receptors and therapeutic applications.

ATP is released from nerve terminals and from activated muscle fibres on stimulation of the rat phrenic nerve.

Adenosine promotes neuronal recovery from reactive oxygen species induced lesion in rat hippocampal slices.

Ecto-AMP deaminase blunts the ATP-derived adenosine A2A receptor facilitation of acetylcholine release at rat motor nerve endings.

Neuroprotection by caffeine and adenosine A2A receptor blockade of beta-amyloid neurotoxicity.

Heteroexchange of purines in the hippocampus: mixing-up or messing-up ATP and adenosine.

Enhanced adenosine A2A receptor facilitation of synaptic transmission in the hippocampus of aged rats.

Decrease of adenosine A1 receptor density and of adenosine neuromodulation in the hippocampus of kindled rats.

Subcellular localization of adenosine A(1) receptors in nerve terminals and synapses of the rat hippocampus.

Adenosine A3 receptors are located in neurons of the rat hippocampus.

Presynaptic modulation controlling neuronal excitability and epileptogenesis: role of kainate, adenosine and neuropeptide Y receptors.

Presynaptic kainate receptors modulating glutamatergic transmission in the rat hippocampus are inhibited by arachidonic acid.

Binding of the prototypical adenosine A(2A) receptor agonist CGS 21680 to the cerebral cortex of adenosine A(1) and A(2A) receptor knockout mice.

Effect of free radicals on adenosine A(2A) and dopamine D2 receptors in the striatum of young adult and aged rats.

Binding of adenosine receptor ligands to brain of adenosine receptor knock-out mice: evidence that CGS 21680 binds to A1 receptors in hippocampus.

Co-localization and functional interaction between adenosine A(2A) and metabotropic group 5 receptors in glutamatergic nerve terminals of the rat striatum.

Involvement of cannabinoid receptors in the regulation of neurotransmitter release in the rodent striatum: a combined immunochemical and pharmacological analysis.

Adenosine and brain function.

Adenosine A2A receptors control the extracellular levels of adenosine through modulation of nucleoside transporters activity in the rat hippocampus.

Dual presynaptic control by ATP of glutamate release via facilitatory P2X1, P2X2/3, and P2X3 and inhibitory P2Y1, P2Y2, and/or P2Y4 receptors in the rat hippocampus.

Different roles of adenosine A1, A2A and A3 receptors in controlling kainate-induced toxicity in cortical cultured neurons.

Modification of adenosine A1 and A2A receptor density in the hippocampus of streptozotocin-induced diabetic rats.

Trkb receptors modulation of glutamate release is limited to a subset of nerve terminals in the adult rat hippocampus.

Presynaptic control of striatal glutamatergic neurotransmission by adenosine A1-A2A receptor heteromers.

Lack of evidence for functional TRPV1 vanilloid receptors in rat hippocampal nerve terminals.

CB1 receptor antagonism increases hippocampal acetylcholine release: site and mechanism of action.

Caffeine and adenosine A(2a) receptor antagonists prevent beta-amyloid (25-35)-induced cognitive deficits in mice.

Interaction between P2X and nicotinic acetylcholine receptors in glutamate nerve terminals of the rat hippocampus.

Increase of cannabinoid CB1 receptor density in the hippocampus of streptozotocin-induced diabetic rats.

Differential glutamate-dependent and glutamate-independent adenosine A1 receptor-mediated modulation of dopamine release in different striatal compartments.

Short-term plasticity of kainate receptor-mediated EPSCs induced by NMDA receptors at hippocampal mossy fiber synapses.

Modification of adenosine modulation of acetylcholine release in the hippocampus of aged rats.

Blockade of adenosine A(2A) receptors prevents staurosporine-induced apoptosis of rat hippocampal neurons.

Different cellular sources and different roles of adenosine: A1 receptor-mediated inhibition through astrocytic-driven volume transmission and synapse-restricted A2A receptor-mediated facilitation of plasticity.

Adenosine receptor heteromers and their integrative role in striatal function.

Adenosine A2A receptors are essential for long-term potentiation of NMDA-EPSCs at hippocampal mossy fiber synapses.

Adenosine A2A receptor blockade prevents memory dysfunction caused by beta-amyloid peptides but not by scopolamine or MK-801.

Adenosine A2A receptor antagonists exert motor and neuroprotective effects by distinct cellular mechanisms.

Modification upon aging of the density of presynaptic modulation systems in the hippocampus.

A critical role of the adenosine A2A receptor in extrastriatal neurons in modulating psychomotor activity as revealed by opposite phenotypes of striatum and forebrain A2A receptor knock-outs.

Electrophysiological and immunocytochemical evidence for P2X purinergic receptors in pancreatic beta cells.

Neuroprotection by adenosine in the brain: From A(1) receptor activation to A (2A) receptor blockade.

GABA release by basket cells onto Purkinje cells, in rat cerebellar slices, is directly controlled by presynaptic purinergic receptors, modulating Ca2+ influx.

Potential therapeutic interest of adenosine A2A receptors in psychiatric disorders.

[Caffeine, adenosine receptors, memory and Alzheimer disease].

N-acyldopamines control striatal input terminals via novel ligand-gated cation channels.

GDNF control of the glutamatergic cortico-striatal pathway requires tonic activation of adenosine A receptors.

Spermine improves recognition memory deficit in a rodent model of Huntington's disease.

Caffeine consumption attenuates neurochemical modifications in the hippocampus of streptozotocin-induced diabetic rats.

Caffeine and an adenosine A(2A) receptor antagonist prevent memory impairment and synaptotoxicity in adult rats triggered by a convulsive episode in early life.

Key modulatory role of presynaptic adenosine A2A receptors in cortical neurotransmission to the striatal direct pathway.

Adenosine A2A receptor blockade prevents synaptotoxicity and memory dysfunction caused by beta-amyloid peptides via p38 mitogen-activated protein kinase pathway.

Caffeine, adenosine receptors, and synaptic plasticity.

Chronic caffeine consumption prevents memory disturbance in different animal models of memory decline.

Therapeutic opportunities for caffeine in Alzheimer's disease and other neurodegenerative disorders.

Putative neuroprotective effects of caffeine in clinical trials. Concluding remarks.

Neuroinflammation, oxidative stress and the pathogenesis of Alzheimer's disease.

Pre-synaptic adenosine A2A receptors control cannabinoid CB1 receptor-mediated inhibition of striatal glutamatergic neurotransmission.

Adenosine receptors and brain diseases: neuroprotection and neurodegeneration.

Adenosine A2A receptors control neuroinflammation and consequent hippocampal neuronal dysfunction.

Cannabinoids inhibit the synaptic uptake of adenosine and dopamine in the rat and mouse striatum.

Pre-synaptic glycine GlyT1 transporter--NMDA receptor interaction: relevance to NMDA autoreceptor activation in the presence of Mg2+ ions.

Enhanced role of adenosine A(2A) receptors in the modulation of LTP in the rat hippocampus upon ageing.

CB₁ receptor activation inhibits neuronal and astrocytic intermediary metabolism in the rat hippocampus.

Adenosine A2A receptors modulate glutamate uptake in cultured astrocytes and gliosomes.

Caffeine consumption prevents diabetes-induced memory impairment and synaptotoxicity in the hippocampus of NONcZNO10/LTJ mice.

Caffeine regulates frontocorticostriatal dopamine transporter density and improves attention and cognitive deficits in an animal model of attention deficit hyperactivity disorder.

Astrocytic adenosine A2A receptors control the amyloid-β peptide-induced decrease of glutamate uptake.

Blockade of adenosine A2A receptors prevents interleukin-1β-induced exacerbation of neuronal toxicity through a p38 mitogen-activated protein kinase pathway.

Caffeine consumption prevents memory impairment, neuronal damage, and adenosine A2A receptors upregulation in the hippocampus of a rat model of sporadic dementia.

Activation of microglial cells triggers a release of brain-derived neurotrophic factor (BDNF) inducing their proliferation in an adenosine A2A receptor-dependent manner: A2A receptor blockade prevents BDNF release and proliferation of microglia.

Caffeine and adenosine A(2A) receptor inactivation decrease striatal neuropathology in a lentiviral-based model of Machado-Joseph disease.

Regulation of fear responses by striatal and extrastriatal adenosine A2A receptors in forebrain.

Ecto-5'-nucleotidase (CD73)-mediated formation of adenosine is critical for the striatal adenosine A2A receptor functions.

Adenosine receptor antagonists including caffeine alter fetal brain development in mice.

Predominant loss of glutamatergic terminal markers in a β-amyloid peptide model of Alzheimer's disease.

A single neurotoxic dose of methamphetamine induces a long-lasting depressive-like behaviour in mice.

Antagonistic interaction between adenosine A2A receptors and Na+/K+-ATPase-α2 controlling glutamate uptake in astrocytes.

ATP P2Y1 receptors control cognitive deficits and neurotoxicity but not glial modifications induced by brain ischemia in mice.

Adenosine A₂A receptors in striatal glutamatergic terminals and GABAergic neurons oppositely modulate psychostimulant action and DARPP-32 phosphorylation.

Prolonged nicotine exposure down-regulates presynaptic NMDA receptors in dopaminergic terminals of the rat nucleus accumbens.

The P2X7 receptor antagonist Brilliant Blue G attenuates contralateral rotations in a rat model of Parkinsonism through a combined control of synaptotoxicity, neurotoxicity and gliosis.

Synaptic and sub-synaptic localization of amyloid-β protein precursor in the rat hippocampus.

Subsynaptic localization of nicotinic acetylcholine receptor subunits: a comparative study in the mouse and rat striatum.

Clinically relevant concentrations of ketamine mainly affect long-term potentiation rather than basal excitatory synaptic transmission and do not change paired-pulse facilitation in mouse hippocampal slices.

Cellular prion protein is present in dopaminergic neurons and modulates the dopaminergic system.

Activation of microglia bolsters synapse formation.

Cellular prion protein (PrP(C)) modulates ethanol-induced behavioral adaptive changes in mice.

Overexpression of Adenosine A2A Receptors in Rats: Effects on Depression, Locomotion, and Anxiety.

Role of microglia adenosine A(2A) receptors in retinal and brain neurodegenerative diseases.

The adenosine neuromodulation system in schizophrenia.

Hippocampal long-term potentiation in adult mice after recovery from ketamine anesthesia.

Nicotinic α7 receptor activation selectively potentiates the function of NMDA receptors in glutamatergic terminals of the nucleus accumbens.

Hyperactivation of D1 and A2A receptors contributes to cognitive dysfunction in Huntington's disease.

Behavioral phenotyping of Parkin-deficient mice: looking for early preclinical features of Parkinson's disease.

Localization and Trafficking of Amyloid-β Protein Precursor and Secretases: Impact on Alzheimer's Disease.

The Effects of Different Concentrations of the α2-Adrenoceptor Agonist Medetomidine on Basal Excitatory Synaptic Transmission and Synaptic Plasticity in Hippocampal Slices of Adult Mice.

Adenosine A2b receptors control A1 receptor-mediated inhibition of synaptic transmission in the mouse hippocampus.

The role of parkinson's disease-associated receptor GPR37 in the hippocampus: functional interplay with the adenosinergic system.

Different danger signals differently impact on microglial proliferation through alterations of ATP release and extracellular metabolism.

Deletion of adenosine A2A receptors from astrocytes disrupts glutamate homeostasis leading to psychomotor and cognitive impairment: relevance to schizophrenia.

Inactivation of adenosine A2A receptors reverses working memory deficits at early stages of Huntington's disease models.

ATP as a multi-target danger signal in the brain.

Adenosine A2AR blockade prevents neuroinflammation-induced death of retinal ganglion cells caused by elevated pressure.

Caffeine acts through neuronal adenosine A2A receptors to prevent mood and memory dysfunction triggered by chronic stress.

Temporal Dissociation of Striatum and Prefrontal Cortex Uncouples Anhedonia and Defense Behaviors Relevant to Depression in 6-OHDA-Lesioned Rats.

Ketone bodies effectively compete with glucose for neuronal acetyl-CoA generation in rat hippocampal slices.

Lack of presynaptic interaction between glucocorticoid and CB1 cannabinoid receptors in GABA- and glutamatergic terminals in the frontal cortex of laboratory rodents.

Does Caffeine Consumption Modify Cerebrospinal Fluid Amyloid-β Levels in Patients with Alzheimer's Disease?

Adenosine A2B receptor activation stimulates glucose uptake in the mouse forebrain.

The Association of Amyloid-β Protein Precursor With α- and β-Secretases in Mouse Cerebral Cortex Synapses Is Altered in Early Alzheimer's Disease.

Adenosine A2A Receptors Modulate α-Synuclein Aggregation and Toxicity.

Characterization of extracellular nucleotide metabolism in Candida albicans.

Selective A2A receptor antagonist prevents microglia-mediated neuroinflammation and protects retinal ganglion cells from high intraocular pressure-induced transient ischemic injury.

Decreased synaptic plasticity in the medial prefrontal cortex underlies short-term memory deficits in 6-OHDA-lesioned rats.

Adenosine A₁ receptors control the metabolic recovery after hypoxia in rat hippocampal slices.

Caffeine exposure during rat brain development causes memory impairment in a sex selective manner that is offset by caffeine consumption throughout life.

Presynaptic P2X1-3 and α3-containing nicotinic receptors assemble into functionally interacting ion channels in the rat hippocampus.

Depression as a Glial-Based Synaptic Dysfunction.

Caffeine Reverts Memory But Not Mood Impairment in a Depression-Prone Mouse Strain with Up-Regulated Adenosine A2A Receptor in Hippocampal Glutamate Synapses.

Stimulation of brain glucose uptake by cannabinoid CB2 receptors and its therapeutic potential in Alzheimer's disease.

Age-Related Changes in the Synaptic Density of Amyloid-β Protein Precursor and Secretases in the Human Cerebral Cortex.

Microglia-derived purines modulate mossy fibre synaptic transmission and plasticity through P2X4 and A1 receptors.

Hierarchical glucocorticoid-endocannabinoid interplay regulates the activation of the nucleus accumbens by insulin.

Oncostatin M promotes excitotoxicity by inhibiting glutamate uptake in astrocytes: implications in HIV-associated neurotoxicity.

Adenosine A2A Receptors in the Amygdala Control Synaptic Plasticity and Contextual Fear Memory.

Early synaptic deficits in the APP/PS1 mouse model of Alzheimer's disease involve neuronal adenosine A2A receptors.

How does adenosine control neuronal dysfunction and neurodegeneration?

Blunted dynamics of adenosine A2A receptors is associated with increased susceptibility to Candida albicans infection in the elderly.

Methamphetamine Induces Anhedonic-Like Behavior and Impairs Frontal Cortical Energetics in Mice.

Adenosine receptors: regulatory players in the preservation of mitochondrial function induced by ischemic preconditioning of rat liver.

Parkinson's disease-associated GPR37 receptor regulates cocaine-mediated synaptic depression in corticostriatal synapses.

Central Ghrelin Resistance Permits the Overconsolidation of Fear Memory.

Caffeine alleviates progressive motor deficits in a transgenic mouse model of spinocerebellar ataxia.

Acyl ghrelin improves cognition, synaptic plasticity deficits and neuroinflammation following amyloid beta (Aβ1-40) administration in mice.