Jeung Whan Han

Cooperation of H2O2-mediated ERK activation with Smad pathway in TGF-beta1 induction of p21WAF1/Cip1.

Apicidin, a histone deacetylase inhibitor, induces apoptosis and Fas/Fas ligand expression in human acute promyelocytic leukemia cells.

Autotaxin promotes motility via G protein-coupled phosphoinositide 3-kinase gamma in human melanoma cells.

Oligosaccharide-linked acyl carrier protein, a novel transmethylase inhibitor, from porcine liver inhibits cell growth.

5-Fluorouracil inhibits nitric oxide production through the inactivation of IkappaB kinase in stomach cancer cells.

Constitutive activation of p70S6k in cancer cells.

Doxorubicin inhibits the production of nitric oxide by colorectal cancer cells.

Cdc42 and Rac1 are necessary for autotaxin-induced tumor cell motility in A2058 melanoma cells.

Expression of autotaxin (NPP-2) is closely linked to invasiveness of breast cancer cells.

Purification and characterization of nitric oxide synthase from Staphylococcus aureus.

Expression of p21(WAF1/Cip1) through Sp1 sites by histone deacetylase inhibitor apicidin requires PI 3-kinase-PKC epsilon signaling pathway.

Hydrogen peroxide mediates arsenite activation of p70(s6k) and extracellular signal-regulated kinase.

Apicidin is a histone deacetylase inhibitor with anti-invasive and anti-angiogenic potentials.

Activation of p21-activated kinase 1 is required for lysophosphatidic acid-induced focal adhesion kinase phosphorylation and cell motility in human melanoma A2058 cells.

In-vitro and in-vivo anti-allergic actions of Arecae semen.

Activation of RBL-2H3 mast cells is dependent on tyrosine phosphorylation of phospholipase D2 by Fyn and Fgr.

Hydrogen peroxide mediates Rac1 activation of S6K1.

Inhibitory activity of Chrysanthemi sibirici herba extract on RBL-2H3 mast cells and compound 48/80-induced anaphylaxis.

Development of a liquid chromatography/electrospray tandem mass spectrometry assay for the quantification of apicidin, a novel histone deacetylase inhibitor, in rat serum: application to a pharmacokinetic study.

Effect of a fermented ginseng extract, BST204, on the expression of cyclooxygenase-2 in murine macrophages.

p85 beta-PIX is required for cell motility through phosphorylations of focal adhesion kinase and p38 MAP kinase.

beta-Carboline alkaloid suppresses NF-kappaB transcriptional activity through inhibition of IKK signaling pathway.

Suppression of inducible nitric oxide synthase and cyclooxygenase-2 expression in RAW 264.7 macrophages by sesquiterpene lactones.

Shp-1 mediates the antiproliferative activity of tissue inhibitor of metalloproteinase-2 in human microvascular endothelial cells.

Apoptotic potential of sesquiterpene lactone ergolide through the inhibition of NF-kappaB signaling pathway.

Histone deacetylase inhibitor apicidin induces cyclin E expression through Sp1 sites.

Rubiae Radix suppresses the activation of mast cells through the inhibition of Syk kinase for anti-allergic activity.

Immunoglobulin can be functionally regulated by protein carboxylmethylation in Fc region.

Phospholipase D2 acts as an essential adaptor protein in the activation of Syk in antigen-stimulated mast cells.

Involvement of HDAC1 and the PI3K/PKC signaling pathways in NF-kappaB activation by the HDAC inhibitor apicidin.

Autotaxin stimulates urokinase-type plasminogen activator expression through phosphoinositide 3-kinase-Akt-nuclear [corrected] factor kappa B signaling cascade in human melanoma cells.

Activation of hypoxia-inducible factor-1alpha is necessary for lysophosphatidic acid-induced vascular endothelial growth factor expression.

PKCepsilon is essential for gelsolin expression by histone deacetylase inhibitor apicidin in human cervix cancer cells.

Reversal of multidrug resistance by 4-chloro-N-(3-((E)-3-(4-hydroxy-3-methoxyphenyl)acryloyl)phenyl)benzamide through the reversible inhibition of P-glycoprotein.

Coordinated change of a ratio of methylated H3-lysine 4 or acetylated H3 to acetylated H4 and DNA methylation is associated with tissue-specific gene expression in cloned pig.

Meliae cortex extract exhibits anti-allergic activity through the inhibition of Syk kinase in mast cells.

Suppression of the NF-kappaB signalling pathway by ergolide, sesquiterpene lactone, in HeLa cells.

Reversine stimulates adipocyte differentiation and downregulates Akt and p70(s6k) signaling pathways in 3T3-L1 cells.

Modification of cap group in delta-lactam-based histone deacetylase (HDAC) inhibitors.

Histone chaperones regulate histone exchange during transcription.

Hypoxia enhances LPA-induced HIF-1alpha and VEGF expression: their inhibition by resveratrol.

Histone deacetylase inhibitor apicidin-mediated drug resistance: involvement of P-glycoprotein.

Curcumin, a constituent of curry, suppresses IgE-mediated allergic response and mast cell activation at the level of Syk.

TIMP-2 disrupts FGF-2-induced downstream signaling pathways.

Histone deacetylase inhibitor KBH-A42 inhibits cytokine production in RAW 264.7 macrophage cells and in vivo endotoxemia model.

Reversine increases the plasticity of lineage-committed cells toward neuroectodermal lineage.

Lysophosphatidic acid receptor 2 and Gi/Src pathway mediate cell motility through cyclooxygenase 2 expression in CAOV-3 ovarian cancer cells.

Rapamycin down-regulates inducible nitric oxide synthase by inducing proteasomal degradation.

Depletion of embryonic stem cell signature by histone deacetylase inhibitor in NCCIT cells: involvement of Nanog suppression.

Oral administration of curcumin suppresses production of matrix metalloproteinase (MMP)-1 and MMP-3 to ameliorate collagen-induced arthritis: inhibition of the PKCdelta/JNK/c-Jun pathway.

A novel gamma-lactam-based histone deacetylase inhibitor potently inhibits the growth of human breast and renal cancer cells.

The tumor suppressor, parafibromin, mediates histone H3 K9 methylation for cyclin D1 repression.

Foxa2 and Nurr1 synergistically yield A9 nigral dopamine neurons exhibiting improved differentiation, function, and cell survival.

HDAC inhibitors downregulate MRP2 expression in multidrug resistant cancer cells: implication for chemosensitization.

Myogenic transcriptional activation of MyoD mediated by replication-independent histone deposition.

Histone chaperones cooperate to mediate Mef2-targeted transcriptional regulation during skeletal myogenesis.

Requirement of protein l-isoaspartyl O-methyltransferase for transcriptional activation of trefoil factor 1 (TFF1) gene by estrogen receptor alpha.

The role of histone chaperones in osteoblastic differentiation of C2C12 myoblasts.

Protein L-isoaspartyl methyltransferase regulates p53 activity.

PRMT6 overexpression upregulates TSP-1 and downregulates MMPs: its implication in motility and invasion.

Dissecting the roles of the histone chaperones reveals the evolutionary conserved mechanism of transcription-coupled deposition of H3.3.

DNA microarray profiling of genes differentially regulated by three heterochromatin protein 1 (HP1) homologs in Drosophila.

Destabilization of TNF-α mRNA by Rapamycin.

Reversine induces multipotency of lineage-committed cells through epigenetic silencing of miR-133a.

The role of tumor suppressor menin in IL-6 regulation in mouse islet tumor cells.

HP1β suppresses metastasis of human cancer cells by decreasing the expression and activation of MMP2.

Epigenetic activation of the Foxa2 gene is required for maintaining the potential of neural precursor cells to differentiate into dopaminergic neurons after expansion.

Identification of small molecules that inhibit the histone chaperone Asf1 and its chromatin function.

Syntaxin 4 regulates the surface localization of a promyogenic receptor Cdo thereby promoting myogenic differentiation.

JQ1, an inhibitor of the epigenetic reader BRD4, suppresses the bidirectional MYC-AP4 axis via multiple mechanisms.

Epigenetic reader BRD4 inhibition as a therapeutic strategy to suppress E2F2-cell cycle regulation circuit in liver cancer.

S6K1 Phosphorylation of H2B Mediates EZH2 Trimethylation of H3: A Determinant of Early Adipogenesis.

Patent cliff and strategic switch: exploring strategic design possibilities in the pharmaceutical industry.

Epigenetic role of nuclear S6K1 in early adipogenesis.

Differential regulation of the histone chaperone HIRA during muscle cell differentiation by a phosphorylation switch.

Mapping the Technological Knowledge Landscape: The Case of Epigenetics.

PKN2 and Cdo interact to activate AKT and promote myoblast differentiation.

A new manufacturing process to remove thrombogenic factors (II, VII, IX, X, and XI) from intravenous immunoglobulin gamma preparations.

Inhibition of Drp1 Ameliorates Synaptic Depression, Aβ Deposition, and Cognitive Impairment in an Alzheimer's Disease Model.