Thomas O. Metz

Automated 20 kpsi RPLC-MS and MS/MS with chromatographic peak capacities of 1000-1500 and capabilities in proteomics and metabolomics.

Making broad proteome protein measurements in 1-5 min using high-speed RPLC separations and high-accuracy mass measurements.

Characterization of the human pancreatic islet proteome by two-dimensional LC/MS/MS.

Targeted protein degradation by Salmonella under phagosome-mimicking culture conditions investigated using comparative peptidomics.

Application of electron transfer dissociation mass spectrometry in analyses of non-enzymatically glycated peptides.

Enrichment and analysis of nonenzymatically glycated peptides: boronate affinity chromatography coupled with electron-transfer dissociation mass spectrometry.

Capillary LC coupled with high-mass measurement accuracy mass spectrometry for metabolic profiling.

Application of proteomics in the discovery of candidate protein biomarkers in a diabetes autoantibody standardization program sample subset.

Elimination of systematic mass measurement errors in liquid chromatography-mass spectrometry based proteomics using regression models and a priori partial knowledge of the sample content.

Proteomic profiling of nonenzymatically glycated proteins in human plasma and erythrocyte membranes.

Application of the accurate mass and time tag approach in studies of the human blood lipidome.

Analysis of non-enzymatically glycated peptides: neutral-loss-triggered MS(3) versus multi-stage activation tandem mass spectrometry.

Improved methods for the enrichment and analysis of glycated peptides.

A perspective on the Maillard reaction and the analysis of protein glycation by mass spectrometry: probing the pathogenesis of chronic disease.

The future of liquid chromatography-mass spectrometry (LC-MS) in metabolic profiling and metabolomic studies for biomarker discovery.

High Resolution Separations and Improved Ion Production and Transmission in Metabolomics.

A statistical framework for protein quantitation in bottom-up MS-based proteomics.

Deletion of GPR40 impairs glucose-induced insulin secretion in vivo in mice without affecting intracellular fuel metabolism in islets.

Performing comparative peptidomics analyses of Salmonella from different growth conditions.

Temporal proteome and lipidome profiles reveal hepatitis C virus-associated reprogramming of hepatocellular metabolism and bioenergetics.

Perturbations in the lipid profile of individuals with newly diagnosed type 1 diabetes mellitus: lipidomics analysis of a Diabetes Antibody Standardization Program sample subset.

Combined statistical analyses of peptide intensities and peptide occurrences improves identification of significant peptides from MS-based proteomics data.

Development of a fibrinogen-specific sandwich enzyme-linked immunosorbent assay microarray assay for distinguishing between blood plasma and serum samples.

Comprehensive identification of glycated peptides and their glycation motifs in plasma and erythrocytes of control and diabetic subjects.

Technologies and approaches to elucidate and model the virulence program of salmonella.

Improved quality control processing of peptide-centric LC-MS proteomics data.

Formation of dehydroalanine from mimosine and cysteine: artifacts in gas chromatography/mass spectrometry based metabolomics.

Systems virology identifies a mitochondrial fatty acid oxidation enzyme, dodecenoyl coenzyme A delta isomerase, required for hepatitis C virus replication and likely pathogenesis.

Separation and classification of lipids using differential ion mobility spectrometry.

A reversed-phase capillary ultra-performance liquid chromatography-mass spectrometry (UPLC-MS) method for comprehensive top-down/bottom-up lipid profiling.

Chelation: a fundamental mechanism of action of AGE inhibitors, AGE breakers, and other inhibitors of diabetes complications.

Dengue virus infection perturbs lipid homeostasis in infected mosquito cells.

Discovery of novel glucose-regulated proteins in isolated human pancreatic islets using LC-MS/MS-based proteomics.

In silico identification software (ISIS): a machine learning approach to tandem mass spectral identification of lipids.

Metabolomic response of human skin tissue to low dose ionizing radiation.

Studying Salmonellae and Yersiniae host-pathogen interactions using integrated 'omics and modeling.

A comparative analysis of computational approaches to relative protein quantification using peptide peak intensities in label-free LC-MS proteomics experiments.

A multi-omic systems approach to elucidating Yersinia virulence mechanisms.

Serum proteomics reveals systemic dysregulation of innate immunity in type 1 diabetes.

Release of severe acute respiratory syndrome coronavirus nuclear import block enhances host transcription in human lung cells.

MultiAlign: a multiple LC-MS analysis tool for targeted omics analysis.

Sequential projection pursuit principal component analysis--dealing with missing data associated with new -omics technologies.

Salmonella modulates metabolism during growth under conditions that induce expression of virulence genes.

A Multi-Omic View of Host-Pathogen-Commensal Interplay in Salmonella-Mediated Intestinal Infection.

Specific mutations in H5N1 mainly impact the magnitude and velocity of the host response in mice.

A network integration approach to predict conserved regulators related to pathogenicity of influenza and SARS-CoV respiratory viruses.

GIM3E: condition-specific models of cellular metabolism developed from metabolomics and expression data.

The succinated proteome.

Decreased abundance of type III secretion system-inducing signals in Arabidopsis mkp1 enhances resistance against Pseudomonas syringae.

Phototrophic biofilm assembly in microbial-mat-derived unicyanobacterial consortia: model systems for the study of autotroph-heterotroph interactions.

Pathogenic influenza viruses and coronaviruses utilize similar and contrasting approaches to control interferon-stimulated gene responses.

The fungus gardens of leaf-cutter ants undergo a distinct physiological transition during biomass degradation.

Bayesian Proteoform Modeling Improves Protein Quantification of Global Proteomic Measurements.

A Statistical Analysis of the Effects of Urease Pre-treatment on the Measurement of the Urinary Metabolome by Gas Chromatography-Mass Spectrometry.

Bayesian proteoform modeling improves protein quantification of global proteomic measurements.

Review, evaluation, and discussion of the challenges of missing value imputation for mass spectrometry-based label-free global proteomics.

Comprehensive Metabolomic, Lipidomic and Microscopic Profiling of Yarrowia lipolytica during Lipid Accumulation Identifies Targets for Increased Lipogenesis.

Diel metabolomics analysis of a hot spring chlorophototrophic microbial mat leads to new hypotheses of community member metabolisms.

Proteomic analysis reveals down-regulation of surfactant protein B in murine type II pneumocytes infected with influenza A virus.

A comprehensive collection of systems biology data characterizing the host response to viral infection.

Silymarin Suppresses Cellular Inflammation By Inducing Reparative Stress Signaling.

Diacyltransferase Activity and Chain Length Specificity of Mycobacterium tuberculosis PapA5 in the Synthesis of Alkyl β-Diol Lipids.

Uncovering biologically significant lipid isomers with liquid chromatography, ion mobility spectrometry and mass spectrometry.

Integrated Omics Analysis of Pathogenic Host Responses during Pandemic H1N1 Influenza Virus Infection: The Crucial Role of Lipid Metabolism.

Multi-omics analysis reveals regulators of the response to nitrogen limitation in Yarrowia lipolytica.

Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking.

MPLEx: a Robust and Universal Protocol for Single-Sample Integrative Proteomic, Metabolomic, and Lipidomic Analyses.

Influence of early life exposure, host genetics and diet on the mouse gut microbiome and metabolome.

Integrating ion mobility spectrometry into mass spectrometry-based exposome measurements: what can it add and how far can it go?

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling.

Elucidation of roles for vitamin B in regulation of folate, ubiquinone, and methionine metabolism.

Lipidomics reveals dramatic lipid compositional changes in the maturing postnatal lung.

LIQUID: an-open source software for identifying lipids in LC-MS/MS-based lipidomics data.

Effects of delayed NSAID administration after experimental eccentric contraction injury - A cellular and proteomics study.

Characterizing the lipid and metabolite changes associated with placental function and pregnancy complications using ion mobility spectrometry-mass spectrometry and mass spectrometry imaging.

PIXiE: an algorithm for automated ion mobility arrival time extraction and collision cross section calculation using global data association.

Leucine Biosynthesis Is Involved in Regulating High Lipid Accumulation in .

Sexual dimorphism in the fetal cardiac response to maternal nutrient restriction.

Multi-platform 'Omics Analysis of Human Ebola Virus Disease Pathogenesis.

Measurement of Fructose-Asparagine Concentrations in Human and Animal Foods.

SPE-IMS-MS: An automated platform for sub-sixty second surveillance of endogenous metabolites and xenobiotics in biofluids.

MERS-CoV and H5N1 influenza virus antagonize antigen presentation by altering the epigenetic landscape.

Biallelic Mutations in ATP5F1D, which Encodes a Subunit of ATP Synthase, Cause a Metabolic Disorder.

Salmonella-Mediated Inflammation Eliminates Competitors for Fructose-Asparagine in the Gut.

Time-resolved Proteome Profiling of Normal Lung Development.

Salinivirga fredricksonii gen. nov., sp. nov., a heterotrophic halophile isolated from a photosynthetic mat, a member of a novel lineage (Salinarimonadaceae fam. nov.) within the order Rhizobiales, and reclassification of the genus Salinarimonas Liu et al. 2010 into Salinarimonadaceae.

QC-ART: A tool for real-time quality control assessment of mass spectrometry-based proteomics data.