Mohanish Deshmukh

Inhibition of the c-Jun N-terminal kinase signaling pathway by the mixed lineage kinase inhibitor CEP-1347 (KT7515) preserves metabolism and growth of trophic factor-deprived neurons.

Multiple channel interactions explain the protection of sympathetic neurons from apoptosis induced by nerve growth factor deprivation.

Exogenous smac induces competence and permits caspase activation in sympathetic neurons.

Critical function of endogenous XIAP in regulating caspase activation during sympathetic neuronal apoptosis.

Stability and apoptotic activity of recombinant human cytochrome c.

Decreased apoptosome activity with neuronal differentiation sets the threshold for strict IAP regulation of apoptosis.

Bcr-Abl-mediated protection from apoptosis downstream of mitochondrial cytochrome c release.

Reduced Apaf-1 levels in cardiomyocytes engage strict regulation of apoptosis by endogenous XIAP.

Enhanced sensitivity to cytochrome c-induced apoptosis mediated by PHAPI in breast cancer cells.

Restricting apoptosis for postmitotic cell survival and its relevance to cancer.

微生物病原体引起的坏死性细胞死亡介导的 inflammasome 组件 CIAS1/cryopyrin/NLRP3 和 ASC。

Chromatin modification of Apaf-1 restricts the apoptotic pathway in mature neurons.

Differential Apaf-1 levels allow cytochrome c to induce apoptosis in brain tumors but not in normal neural tissues.

Glucose metabolism inhibits apoptosis in neurons and cancer cells by redox inactivation of cytochrome c.

Skeletal muscle differentiation evokes endogenous XIAP to restrict the apoptotic pathway.

Lack of X-linked inhibitor of apoptosis protein leads to increased apoptosis and tissue loss following neonatal brain injury.

miR-29b is activated during neuronal maturation and targets BH3-only genes to restrict apoptosis.

Rescue from excitotoxicity and axonal degeneration accompanied by age-dependent behavioral and neuroanatomical alterations in caspase-6-deficient mice.