Corey Nislow

"Chemogenomics: tools for protein families" and "Chemical genomics: chemical and biological integration".

Chemogenomic profiling: identifying the functional interactions of small molecules in yeast.

Mechanisms of haploinsufficiency revealed by genome-wide profiling in yeast.

Genome-wide requirements for resistance to functionally distinct DNA-damaging agents.

Introns regulate RNA and protein abundance in yeast.

A unique and universal molecular barcode array.

Experimental approaches to identify genetic networks.

Chemical genomic profiling for identifying intracellular targets of toxicants producing Parkinson's disease.

Systematic pathway analysis using high-resolution fitness profiling of combinatorial gene deletions.

Accelerating the discovery of biologically active small molecules using a high-throughput yeast halo assay.

Identification of genes involved in the toxic response of Saccharomyces cerevisiae against iron and copper overload by parallel analysis of deletion mutants.

A high-resolution atlas of nucleosome occupancy in yeast.

Examining protein protein interactions using endogenously tagged yeast arrays: the cross-and-capture system.

Genome-wide analysis of barcoded Saccharomyces cerevisiae gene-deletion mutants in pooled cultures.

Chemical-genetic approaches for exploring the mode of action of natural products.

The chemical genomic portrait of yeast: uncovering a phenotype for all genes.

Identification of small molecule inhibitors of Pseudomonas aeruginosa exoenzyme S using a yeast phenotypic screen.

The extensive and condition-dependent nature of epistasis among whole-genome duplicates in yeast.

An integrated platform of genomic assays reveals small-molecule bioactivities.

Yeast Barcoders: a chemogenomic application of a universal donor-strain collection carrying bar-code identifiers.

Off-target effects of psychoactive drugs revealed by genome-wide assays in yeast.

Yeast chemical genomics and drug discovery: an update.

Combination chemical genetics.

Chemical-genetic profiling of imidazo[1,2-a]pyridines and -pyrimidines reveals target pathways conserved between yeast and human cells.

A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters.

Combining chemical genomics screens in yeast to reveal spectrum of effects of chemical inhibition of sphingolipid biosynthesis.

Knocking sense into regulatory pathways.

Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis.

Novel insights into iron metabolism by integrating deletome and transcriptome analysis in an iron deficiency model of the yeast Saccharomyces cerevisiae.

Precise gene-dose alleles for chemical genetics.

A molecular barcoded yeast ORF library enables mode-of-action analysis of bioactive compounds.

Self-reporting cells.

Chemogenomic approaches to elucidation of gene function and genetic pathways.

Alternative splicing of PTC7 in Saccharomyces cerevisiae determines protein localization.

Quantitative phenotyping via deep barcode sequencing.

Two-color cell array screen reveals interdependent roles for histone chaperones and a chromatin boundary regulator in histone gene repression.

A comparative analysis of DNA barcode microarray feature size.

You too can play with an edge.

Recent advances and method development for drug target identification.

Integrating high-throughput genetic interaction mapping and high-content screening to explore yeast spindle morphogenesis.

The genetic landscape of a cell.

Systematic analysis of genome-wide fitness data in yeast reveals novel gene function and drug action.

Genotype to phenotype: a complex problem.

Highly-multiplexed barcode sequencing: an efficient method for parallel analysis of pooled samples.

A universal TagModule collection for parallel genetic analysis of microorganisms.

Most "dark matter" transcripts are associated with known genes.

A predictive model for drug bioaccumulation and bioactivity in Caenorhabditis elegans.

A survey of yeast genomic assays for drug and target discovery.

Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation.

Diversity of eukaryotic DNA replication origins revealed by genome-wide analysis of chromatin structure.

Exploring gene function and drug action using chemogenomic dosage assays.

Gene annotation and drug target discovery in Candida albicans with a tagged transposon mutant collection.

Endosomal protein sorting and autophagy genes contribute to the regulation of yeast life span.

Extensive role of the general regulatory factors, Abf1 and Rap1, in determining genome-wide chromatin structure in budding yeast.

Knocking out multigene redundancies via cycles of sexual assortment and fluorescence selection.

Systematic exploration of essential yeast gene function with temperature-sensitive mutants.

The synthetic genetic interaction network reveals small molecules that target specific pathways in Sacchromyces cerevisiae.

The SWI/SNF complex acts to constrain distribution of the centromeric histone variant Cse4.

A comprehensive platform for highly multiplexed mammalian functional genetic screens.

Dosage suppression genetic interaction networks enhance functional wiring diagrams of the cell.

Design, synthesis, and characterization of a highly effective Hog1 inhibitor: a powerful tool for analyzing MAP kinase signaling in yeast.

Design, synthesis and characterization of a highly effective inhibitor for analog-sensitive (as) kinases.

New azole antifungal agents with novel modes of action: synthesis and biological studies of new tridentate ligands based on pyrazole and triazole.

Signature-tagged mutagenesis to characterize genes through competitive selection of bar-coded genome libraries.

The automated cell: compound and environment screening system (ACCESS) for chemogenomic screening.

Displaying chemical information on a biological network using Cytoscape.

Evolution of nucleosome occupancy: conservation of global properties and divergence of gene-specific patterns.

Curcumin inhibits growth of Saccharomyces cerevisiae through iron chelation.

Nucleosome-coupled expression differences in closely-related species.

A systems biology approach reveals the role of a novel methyltransferase in response to chemical stress and lipid homeostasis.

Compound prioritization methods increase rates of chemical probe discovery in model organisms.

Dafadine inhibits DAF-9 to promote dauer formation and longevity of Caenorhabditis elegans.

Systematic exploration of synergistic drug pairs.

Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia.

Multiple means to the same end: the genetic basis of acquired stress resistance in yeast.

Restriction of histone gene transcription to S phase by phosphorylation of a chromatin boundary protein.

Bugs, drugs and chemical genomics.

Genomic approaches for determining nucleosome occupancy in yeast.

Mitochondrial electron transport is the cellular target of the oncology drug elesclomol.

Dafadine inhibits DAF-9 to promote dauer formation and longevity of Caenorhabditis elegans.

Target identification by chromatographic co-elution: monitoring of drug-protein interactions without immobilization or chemical derivatization.

A global perspective of the genetic basis for carbonyl stress resistance.

Genome sequence of Shigella flexneri serotype 5a strain M90T Sm.

Identification of yeast genes that confer resistance to chitosan oligosaccharide (COS) using chemogenomics.

A novel calcineurin-independent activity of cyclosporin A in Saccharomyces cerevisiae.

Barcode sequencing for understanding drug-gene interactions.

Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress.

Comparative chemogenomics to examine the mechanism of action of dna-targeted platinum-acridine anticancer agents.

Global gene deletion analysis exploring yeast filamentous growth.

An algorithm for chemical genomic profiling that minimizes batch effects: bucket evaluations.

Genome-wide analysis of intracellular pH reveals quantitative control of cell division rate by pH(c) in Saccharomyces cerevisiae.

Functional analysis with a barcoder yeast gene overexpression system.

Effects of the Paf1 complex and histone modifications on snoRNA 3'-end formation reveal broad and locus-specific regulation.

Timing of transcriptional quiescence during gametogenesis is controlled by global histone H3K4 demethylation.

A phenotypic screening platform to identify small molecule modulators of Chlamydomonas reinhardtii growth, motility and photosynthesis.

Lysosomal disruption preferentially targets acute myeloid leukemia cells and progenitors.

Chemical genomic screening of a Saccharomyces cerevisiae genomewide mutant collection reveals genes required for defense against four antimicrobial peptides derived from proteins found in human saliva.

Chromatin is an ancient innovation conserved between Archaea and Eukarya.

Global analysis of SUMO chain function reveals multiple roles in chromatin regulation.

Genetic and genomic architecture of the evolution of resistance to antifungal drug combinations.

Reconstitution and characterization of eukaryotic N6-threonylcarbamoylation of tRNA using a minimal enzyme system.

A compendium of nucleosome and transcript profiles reveals determinants of chromatin architecture and transcription.

DNA-damaging agents in cancer chemotherapy: serendipity and chemical biology.

A high-throughput yeast assay identifies synergistic drug combinations.

Miniature short hairpin RNA screens to characterize antiproliferative drugs.

A novel small molecule methyltransferase is important for virulence in Candida albicans.

A unified model for yeast transcript definition.

PITPs as targets for selectively interfering with phosphoinositide signaling in cells.

Sequencing and functional analysis of the genome of a nematode egg-parasitic fungus, Pochonia chlamydosporia.

CHIP-MYTH: a novel interactive proteomics method for the assessment of agonist-dependent interactions of the human β₂-adrenergic receptor.

GC-rich DNA elements enable replication origin activity in the methylotrophic yeast Pichia pastoris.

Large-scale identification and analysis of suppressive drug interactions.

Broad metabolic sensitivity profiling of a prototrophic yeast deletion collection.

Mapping the cellular response to small molecules using chemogenomic fitness signatures.

A genome scale overexpression screen to reveal drug activity in human cells.

Genes required for survival in microgravity revealed by genome-wide yeast deletion collections cultured during spaceflight.

Caenorhabditis elegans is a useful model for anthelmintic discovery.

Genome-wide RNAi analysis reveals that simultaneous inhibition of specific mevalonate pathway genes potentiates tumor cell death.

Global Analysis of the Fungal Microbiome in Cystic Fibrosis Patients Reveals Loss of Function of the Transcriptional Repressor Nrg1 as a Mechanism of Pathogen Adaptation.

Dual action antifungal small molecule modulates multidrug efflux and TOR signaling.

Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles.