Medical Research Council (MRC),
Cell Biology Unit and Laboratory for Molecular Cell Biology,
Medical Research Council,
Laboratory for Molecular Cell Biology,
Medical Research Council (MRC), Cell Biology Unit and Laboratory for Molecular Cell Biology,
Medical Research Council, Laboratory for Molecular Cell Biology
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Inositol pyrophosphates are required for DNA hyperrecombination in protein kinase c1 mutant yeast.
Biochemistry Feb, 2002 | Pubmed ID: 11851397
Role of dopamine D2-like receptors in cocaine self-administration: studies with D2 receptor mutant mice and novel D2 receptor antagonists.
The Journal of neuroscience : the official journal of the Society for Neuroscience Apr, 2002 | Pubmed ID: 11923462
Inositol pyrophosphates regulate endocytic trafficking.
Proceedings of the National Academy of Sciences of the United States of America Oct, 2002 | Pubmed ID: 12391334
Inositol pyrophosphates mediate chemotaxis in Dictyostelium via pleckstrin homology domain-PtdIns(3,4,5)P3 interactions.
Cell Sep, 2003 | Pubmed ID: 13678580
Simultaneous absence of dopamine D1 and D2 receptor-mediated signaling is lethal in mice.
Proceedings of the National Academy of Sciences of the United States of America Aug, 2004 | Pubmed ID: 15272078
Inositol hexakisphosphate kinase-2, a physiologic mediator of cell death.
The Journal of biological chemistry Jan, 2005 | Pubmed ID: 15533939
Phosphorylation of proteins by inositol pyrophosphates.
Science (New York, N.Y.) Dec, 2004 | Pubmed ID: 15604408
Inositol pyrophosphates regulate cell death and telomere length through phosphoinositide 3-kinase-related protein kinases.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2005 | Pubmed ID: 15665079
Inositol polyphosphate multikinase is a nuclear PI3-kinase with transcriptional regulatory activity.
Proceedings of the National Academy of Sciences of the United States of America Sep, 2005 | Pubmed ID: 16123124
Inhibition of the phosphatidylinositol 3-kinase/Akt pathway by inositol pentakisphosphate results in antiangiogenic and antitumor effects.
Cancer research Sep, 2005 | Pubmed ID: 16166311
Extraction and analysis of soluble inositol polyphosphates from yeast.
Nature protocols , 2006 | Pubmed ID: 17406485
Inositol pyrophosphates get the vip1 treatment.
Cell May, 2007 | Pubmed ID: 17512396
Protein pyrophosphorylation by inositol pyrophosphates is a posttranslational event.
Proceedings of the National Academy of Sciences of the United States of America Sep, 2007 | Pubmed ID: 17873058
Inositol polyphosphate multikinase: metabolic architect of nuclear inositides.
Frontiers in bioscience : a journal and virtual library , 2008 | Pubmed ID: 17981594
Requirement of inositol pyrophosphates for full exocytotic capacity in pancreatic beta cells.
Science (New York, N.Y.) Nov, 2007 | Pubmed ID: 18033884
Polyunsaturated fatty acids influence synaptojanin localization to regulate synaptic vesicle recycling.
Molecular biology of the cell Mar, 2008 | Pubmed ID: 18094048
Human ITPK1: a reversible inositol phosphate kinase/phosphatase that links receptor-dependent phospholipase C to Ca2+-activated chloride channels.
Science signaling , 2008 | Pubmed ID: 18272466
The mood stabilizer valproate inhibits both inositol- and diacylglycerol-signaling pathways in Caenorhabditis elegans.
Molecular biology of the cell May, 2008 | Pubmed ID: 18287529
Inositol hexakisphosphate kinase products contain diphosphate and triphosphate groups.
Chemistry & biology Mar, 2008 | Pubmed ID: 18355727
Are inositol pyrophosphates signalling molecules?
Journal of cellular physiology Jul, 2009 | Pubmed ID: 19326391
Inositol pyrophosphates and their unique metabolic complexity: analysis by gel electrophoresis.
PloS one , 2009 | Pubmed ID: 19440344
Inositol pyrophosphates modulate hydrogen peroxide signalling.
The Biochemical journal Oct, 2009 | Pubmed ID: 19614566
Inositol pyrophosphate mediated pyrophosphorylation of AP3B1 regulates HIV-1 Gag release.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2009 | Pubmed ID: 19934039
An NGF-responsive element targets myo-inositol monophosphatase-1 mRNA to sympathetic neuron axons.
Nature neuroscience Mar, 2010 | Pubmed ID: 20118926
Synthesis of InsP7 by the Inositol Hexakisphosphate Kinase 1 (IP6K1).
Methods in molecular biology (Clifton, N.J.) , 2010 | Pubmed ID: 20645182
Inositol hexakisphosphate kinases promote autophagy.
The international journal of biochemistry & cell biology Dec, 2010 | Pubmed ID: 20883817
The signaling role of inositol hexakisphosphate kinases (IP6Ks).
Advances in enzyme regulation , 2011 | Pubmed ID: 21035498
Inositol polyphosphate multikinase is a physiologic PI3-kinase that activates Akt/PKB.
Proceedings of the National Academy of Sciences of the United States of America Jan, 2011 | Pubmed ID: 21220345
IP6K gene identification in plant genomes by tag searching.
BMC proceedings , 2011 | Pubmed ID: 21554757
Inositol hexakisphosphate kinases induce cell death in Huntington disease.
The Journal of biological chemistry Jul, 2011 | Pubmed ID: 21652713
Identification of an evolutionarily conserved family of inorganic polyphosphate endopolyphosphatases.
The Journal of biological chemistry Sep, 2011 | Pubmed ID: 21775424
Influence of inositol pyrophosphates on cellular energy dynamics.
Science (New York, N.Y.) Nov, 2011 | Pubmed ID: 22076377
Cell signalling by inositol pyrophosphates.
Sub-cellular biochemistry , 2012 | Pubmed ID: 22374099
How inositol pyrophosphates control cellular phosphate homeostasis?
Advances in biological regulation May, 2012 | Pubmed ID: 22781748
Arginine transcriptional response does not require inositol phosphate synthesis.
The Journal of biological chemistry Nov, 2012 | Pubmed ID: 22992733
Inositol pyrophosphates: between signalling and metabolism.
The Biochemical journal Jun, 2013 | Pubmed ID: 23725456
Modulation of inositol polyphosphate levels regulates neuronal differentiation.
Molecular biology of the cell Sep, 2013 | Pubmed ID: 23864704
Inositol pyrophosphates regulate JMJD2C-dependent histone demethylation.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2013 | Pubmed ID: 24191012
Analysis of Dictyostelium discoideum inositol pyrophosphate metabolism by gel electrophoresis.
PloS one , 2014 | Pubmed ID: 24416420
Functions of inorganic polyphosphates in eukaryotic cells: a coat of many colours.
Biochemical Society transactions Feb, 2014 | Pubmed ID: 24450634
Inositol phosphates induce DAPI fluorescence shift.
The Biochemical journal Jun, 2014 | Pubmed ID: 24670057
Raman spectroscopy detection of phytic acid in plant seeds reveals the absence of inorganic polyphosphate.
Molecular plant May, 2015 | Pubmed ID: 25620771
Protein polyphosphorylation of lysine residues by inorganic polyphosphate.
Molecular cell Apr, 2015 | Pubmed ID: 25773596
A novel method for the purification of inositol phosphates from biological samples reveals that no phytate is present in human plasma or urine.
Open biology Mar, 2015 | Pubmed ID: 25808508
VIH2 Regulates the Synthesis of Inositol Pyrophosphate InsP8 and Jasmonate-Dependent Defenses in Arabidopsis.
The Plant cell Apr, 2015 | Pubmed ID: 25901085
Prometabolites of 5-Diphospho-myo-inositol Pentakisphosphate.
Angewandte Chemie (International ed. in English) Aug, 2015 | Pubmed ID: 26014370
Fungal Inositol Pyrophosphate IP7 Is Crucial for Metabolic Adaptation to the Host Environment and Pathogenicity.
mBio Jun, 2015 | Pubmed ID: 26037119
Why always lysine? The ongoing tale of one of the most modified amino acids.
Advances in biological regulation Jan, 2016 | Pubmed ID: 26482291
There is no 'Conundrum' of InsP6.
Open biology Nov, 2015 | Pubmed ID: 26581573
Developmental accumulation of inorganic polyphosphate affects germination and energetic metabolism in Dictyostelium discoideum.
Proceedings of the National Academy of Sciences of the United States of America Jan, 2016 | Pubmed ID: 26755590
The new world of inorganic polyphosphates.
Biochemical Society transactions Feb, 2016 | Pubmed ID: 26862182
Phosphate, inositol and polyphosphates.
Biochemical Society transactions Feb, 2016 | Pubmed ID: 26862212
Identification of a major IP5 kinase in Cryptococcus neoformans confirms that PP-IP5/IP7, not IP6, is essential for virulence.
Scientific reports Apr, 2016 | Pubmed ID: 27033523
Inositol Pyrophosphate Profiling of Two HCT116 Cell Lines Uncovers Variation in InsP8 Levels.
PloS one , 2016 | Pubmed ID: 27788189
Protein pyrophosphorylation: moving forward.
The Biochemical journal 11, 2016 | Pubmed ID: 27789744
Eukaryotic Phosphate Homeostasis: The Inositol Pyrophosphate Perspective.
Trends in biochemical sciences 03, 2017 | Pubmed ID: 27876550
Importance of Radioactive Labelling to Elucidate Inositol Polyphosphate Signalling.
Topics in current chemistry (Cham) Feb, 2017 | Pubmed ID: 28101851
Has Inositol Played Any Role in the Origin of Life?
Life (Basel, Switzerland) Jun, 2017 | Pubmed ID: 28587245
The inositol pyrophosphate synthesis pathway in Trypanosoma brucei is linked to polyphosphate synthesis in acidocalcisomes.
Molecular microbiology Oct, 2017 | Pubmed ID: 28792096
Microbial inositol polyphosphate metabolic pathway as drug development target.
Advances in biological regulation 01, 2018 | Pubmed ID: 28964726
IP3-4 kinase Arg1 regulates cell wall homeostasis and surface architecture to promote clearance of Cryptococcus neoformans infection in a mouse model.
Virulence Oct, 2017 | Pubmed ID: 28976803
Inositol Polyphosphate Kinases, Fungal Virulence and Drug Discovery.
Journal of fungi (Basel, Switzerland) Sep, 2016 | Pubmed ID: 29376941
Asp1 Bifunctional Activity Modulates Spindle Function via Controlling Cellular Inositol Pyrophosphate Levels in Schizosaccharomyces pombe.
Molecular and cellular biology 05, 2018 | Pubmed ID: 29440310
IP6 is an HIV pocket factor that prevents capsid collapse and promotes DNA synthesis.
eLife 05, 2018 | Pubmed ID: 29848441
Screening a Protein Array with Synthetic Biotinylated Inorganic Polyphosphate To Define the Human PolyP-ome.
ACS chemical biology 08, 2018 | Pubmed ID: 29924597
Inositol Phosphates Purification Using Titanium Dioxide Beads.
Bio-protocol Aug, 2018 | Pubmed ID: 30148188
Rab4A organizes endosomal domains for sorting cargo to lysosome-related organelles.
Journal of cell science 09, 2018 | Pubmed ID: 30154210
Lithium and fluoxetine regulate the rate of phosphoinositide synthesis in neurons: a new view of their mechanisms of action in bipolar disorder.
Translational psychiatry 08, 2018 | Pubmed ID: 30171184
Hydrophilic interaction liquid chromatography-tandem mass spectrometry for the quantitative analysis of mammalian-derived inositol poly/pyrophosphates.
Journal of chromatography. A Oct, 2018 | Pubmed ID: 30220429
Crosstalk between Ras and inositol phosphate signaling revealed by lithium action on inositol monophosphatase in Schizophyllum commune.
Advances in biological regulation 05, 2019 | Pubmed ID: 30639095
Inositol Polyphosphate Multikinase (), a Gene Coding for a Potential Moonlighting Protein, Contributes to Human Female Longevity.
Genes 02, 2019 | Pubmed ID: 30744060
The inositol hexakisphosphate kinases IP6K1 and -2 regulate human cellular phosphate homeostasis, including XPR1-mediated phosphate export.
The Journal of biological chemistry 07, 2019 | Pubmed ID: 31186349
Harnessing C-labeled -inositol to interrogate inositol phosphate messengers by NMR.
Chemical science May, 2019 | Pubmed ID: 31191882
Fungal Kinases With a Sweet Tooth: Pleiotropic Roles of Their Phosphorylated Inositol Sugar Products in the Pathogenicity of Present Novel Drug Targeting Opportunities.
Frontiers in cellular and infection microbiology , 2019 | Pubmed ID: 31380293
ITPK1 and ITPK2 Have an Evolutionarily Conserved Phytic Acid Kinase Activity.
ACS chemical biology 10, 2019 | Pubmed ID: 31525024
ITPK1 mediates the lipid-independent synthesis of inositol phosphates controlled by metabolism.
Proceedings of the National Academy of Sciences of the United States of America 12, 2019 | Pubmed ID: 31754032
Dictyostelium discoideum as a Model to Study Inositol Polyphosphates and Inorganic Polyphosphate.
Methods in molecular biology (Clifton, N.J.) , 2020 | Pubmed ID: 31773570
Development of a yeast model to study the contribution of vacuolar polyphosphate metabolism to lysine polyphosphorylation.
The Journal of biological chemistry 02, 2020 | Pubmed ID: 31844018
Cellular IP Levels Limit HIV Production while Viruses that Cannot Efficiently Package IP Are Attenuated for Infection and Replication.
Cell reports 12, 2019 | Pubmed ID: 31851928
Inorganic polyphosphate in mammals: where's Wally?
Biochemical Society transactions 02, 2020 | Pubmed ID: 32049314
Interplay between primary familial brain calcification-associated SLC20A2 and XPR1 phosphate transporters requires inositol polyphosphates for control of cellular phosphate homeostasis.
The Journal of biological chemistry 07, 2020 | Pubmed ID: 32393577
Effects of the putative lithium mimetic ebselen on pilocarpine-induced neural activity.
European journal of pharmacology Sep, 2020 | Pubmed ID: 32687920
IP-SPX Domain Interaction Controls Fungal Virulence by Stabilizing Phosphate Signaling Machinery.
mBio 10, 2020 | Pubmed ID: 33082258
Analysis of inositol phosphate metabolism by capillary electrophoresis electrospray ionization mass spectrometry.
Nature communications 11, 2020 | Pubmed ID: 33247133
MINPP1 prevents intracellular accumulation of the chelator inositol hexakisphosphate and is mutated in Pontocerebellar Hypoplasia.
Nature communications 11, 2020 | Pubmed ID: 33257696
Phytocannabinoid-dependent mTORC1 regulation is dependent upon inositol polyphosphate multikinase activity.
British journal of pharmacology 03, 2021 | Pubmed ID: 33347604
Inositol phosphate kinases in the eukaryote landscape.
Advances in biological regulation 01, 2021 | Pubmed ID: 33422459
IP6K3 and IPMK variations in LOAD and longevity: Evidence for a multifaceted signaling network at the crossroad between neurodegeneration and survival.
Mechanisms of ageing and development 04, 2021 | Pubmed ID: 33497757
Cytoplasmic cleavage of IMPA1 3' UTR is necessary for maintaining axon integrity.
Cell reports Feb, 2021 | Pubmed ID: 33626357
A stable immature lattice packages IP for HIV capsid maturation.
Science advances Mar, 2021 | Pubmed ID: 33692109
ITPK1 is an InsP/ADP phosphotransferase that controls phosphate signaling in Arabidopsis.
Molecular plant Jul, 2021 | Pubmed ID: 34274522
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