Jong-Ik Hwang

Molecular cloning and characterization of a novel phospholipase C, PLC-eta.

Role of Galpha12 and Galpha13 as novel switches for the activity of Nrf2, a key antioxidative transcription factor.

Cloning and activation of the bullfrog apelin receptor: Gi/o coupling and high affinity for [Pro1]apelin-13.

Extracellular loop 3 (ECL3) and ECL3-proximal transmembrane domains VI and VII of the mesotocin and vasotocin receptors confer differential ligand selectivity and signaling activity.

Involvement of amino acids flanking Glu7.32 of the gonadotropin-releasing hormone receptor in the selectivity of antagonists.

Identification of farnesyl pyrophosphate and N-arachidonylglycine as endogenous ligands for GPR92.

Molecular cloning of the bullfrog kisspeptin receptor GPR54 with high sensitivity to Xenopus kisspeptin.

GbetaL regulates TNFalpha-induced NF-kappaB signaling by directly inhibiting the activation of IkappaB kinase.

Gene expression profiling of light-induced retinal degeneration in phototransduction gene knockout mice.

Molecular evolution of multiple forms of kisspeptins and GPR54 receptors in vertebrates.

A gonadotropin-releasing hormone-II antagonist induces autophagy of prostate cancer cells.

Phylogenetic history, pharmacological features, and signal transduction of neurotensin receptors in vertebrates.

Splicing variants of the orphan G-protein-coupled receptor GPR56 regulate the activity of transcription factors associated with tumorigenesis.

Suppression of NF-kappaB signaling by KEAP1 regulation of IKKbeta activity through autophagic degradation and inhibition of phosphorylation.

Molecular coevolution of kisspeptins and their receptors from fish to mammals.

Tyr1 and Ile7 of glucose-dependent insulinotropic polypeptide (GIP) confer differential ligand selectivity toward GIP and glucagon-like peptide-1 receptors.

Revisiting the evolution of gonadotropin-releasing hormones and their receptors in vertebrates: secrets hidden in genomes.

Regulation of IκB kinase by GβL through recruitment of the protein phosphatases.

Insulin contributes to fine-tuning of the pancreatic beta-cell response to glucagon-like peptide-1.

Evolutionarily conserved residues at glucagon-like peptide-1 (GLP-1) receptor core confer ligand-induced receptor activation.

Molecular Coevolution of Neuropeptides Gonadotropin-Releasing Hormone and Kisspeptin with their Cognate G Protein-Coupled Receptors.

Spatiotemporal expression and functional implication of CXCL14 in the developing mice cerebellum.

Anti-cancer activity of a novel small molecule compound that simultaneously activates p53 and inhibits NF-κB signaling.

Generation and characterization of human heme oxygenase-1 transgenic pigs.

CXCL14 enhances proliferation and migration of NCI-H460 human lung cancer cells overexpressing the glycoproteins containing heparan sulfate or sialic acid.

Structural and molecular conservation of glucagon-like Peptide-1 and its receptor confers selective ligand-receptor interaction.

Expansion of secretin-like G protein-coupled receptors and their peptide ligands via local duplications before and after two rounds of whole-genome duplication.

A novel glucagon-related peptide (GCRP) and its receptor GCRPR account for coevolution of their family members in vertebrates.

Expression analysis of combinatorial genes using a bi-cistronic T2A expression system in porcine fibroblasts.

Local duplication of gonadotropin-releasing hormone (GnRH) receptor before two rounds of whole genome duplication and origin of the mammalian GnRH receptor.

Coevolution of the spexin/galanin/kisspeptin family: Spexin activates galanin receptor type II and III.

A splicing variant of NME1 negatively regulates NF-κB signaling and inhibits cancer metastasis by interacting with IKKβ.

Apoptotic death of prostate cancer cells by a gonadotropin-releasing hormone-II antagonist.

Does Kisspeptin Belong to the Proposed RF-Amide Peptide Family?

A Novel Long-Acting Glucagon-Like Peptide-1 Agonist with Improved Efficacy in Insulin Secretion and β-Cell Growth.

Ligand binding pocket formed by evolutionarily conserved residues in the glucagon-like peptide-1 (GLP-1) receptor core domain.

Human thrombomodulin regulates complement activation as well as the coagulation cascade in xeno-immune response.

Dimer of arfaptin 2 regulates NF-κB signaling by interacting with IKKβ/NEMO and inhibiting IKKβ kinase activity.

Prevertebrate Local Gene Duplication Facilitated Expansion of the Neuropeptide GPCR Superfamily.

NME1L Negatively Regulates IGF1-Dependent Proliferation of Breast Cancer Cells.

Beneficial effects of the transgenic expression of human sTNF-αR-Fc and HO-1 on pig-to-mouse islet xenograft survival.

Ninjurin1 suppresses metastatic property of lung cancer cells through inhibition of interleukin 6 signaling pathway.

Development of Spexin-based Human Galanin Receptor Type II-Specific Agonists with Increased Stability in Serum and Anxiolytic Effect in Mice.

Characterization of Functional Domains in NME1L Regulation of NF-κB Signaling.

Ninjurin1 inhibits colitis-mediated colon cancer development and growth by suppression of macrophage infiltration through repression of FAK signaling.

Human antibody reactivity against xenogeneic N-glycolylneuraminic acid and galactose-α-1,3-galactose antigen.

The accessory proteins REEP5 and REEP6 refine CXCR1-mediated cellular responses and lung cancer progression.

Generation of CMAHKO/GTKO/shTNFRI-Fc/HO-1 quadruple gene modified pigs.

Nafamostat mesilate negatively regulates the metastasis of triple-negative breast cancer cells.

Conformational signatures in β-arrestin2 reveal natural biased agonism at a G-protein-coupled receptor.

Ninjurin1 Plays a Crucial Role in Pulmonary Fibrosis by Promoting Interaction between Macrophages and Alveolar Epithelial Cells.

Generation by somatic cell nuclear transfer of GGTA1 knockout pigs expressing soluble human TNFRI-Fc and human HO-1.

SP-8356, a (1S)-(-)-verbenone derivative, exerts in vitro and in vivo anti-breast cancer effects by inhibiting NF-κB signaling.

Spexin-Based Galanin Receptor Type 2 Agonist for Comorbid Mood Disorders and Abnormal Body Weight.