Jae Young Seong

The accessory proteins REEP5 and REEP6 refine CXCR1-mediated cellular responses and lung cancer progression.

Cellular and molecular biology of orphan G protein-coupled receptors.

Molecular evolution of neuropeptide receptors with regard to maintaining high affinity to their authentic ligands.

Integrin-linked kinase controls Notch1 signaling by down-regulation of protein stability through Fbw7 ubiquitin ligase.

Cloning and activation of the bullfrog apelin receptor: Gi/o coupling and high affinity for [Pro1]apelin-13.

Extracellular loop 3 (ECL3) and ECL3-proximal transmembrane domains VI and VII of the mesotocin and vasotocin receptors confer differential ligand selectivity and signaling activity.

Involvement of amino acids flanking Glu7.32 of the gonadotropin-releasing hormone receptor in the selectivity of antagonists.

Identification of farnesyl pyrophosphate and N-arachidonylglycine as endogenous ligands for GPR92.

Molecular cloning of the bullfrog kisspeptin receptor GPR54 with high sensitivity to Xenopus kisspeptin.

GbetaL regulates TNFalpha-induced NF-kappaB signaling by directly inhibiting the activation of IkappaB kinase.

Molecular evolution of multiple forms of kisspeptins and GPR54 receptors in vertebrates.

A gonadotropin-releasing hormone-II antagonist induces autophagy of prostate cancer cells.

Nova-1 mediates glucocorticoid-induced inhibition of pre-mRNA splicing of gonadotropin-releasing hormone transcripts.

Phylogenetic history, pharmacological features, and signal transduction of neurotensin receptors in vertebrates.

Splicing variants of the orphan G-protein-coupled receptor GPR56 regulate the activity of transcription factors associated with tumorigenesis.

Suppression of NF-kappaB signaling by KEAP1 regulation of IKKbeta activity through autophagic degradation and inhibition of phosphorylation.

Molecular coevolution of kisspeptins and their receptors from fish to mammals.

Tyr1 and Ile7 of glucose-dependent insulinotropic polypeptide (GIP) confer differential ligand selectivity toward GIP and glucagon-like peptide-1 receptors.

Revisiting the evolution of gonadotropin-releasing hormones and their receptors in vertebrates: secrets hidden in genomes.

Regulation of IκB kinase by GβL through recruitment of the protein phosphatases.

Secretoneurin stimulates the production and release of luteinizing hormone in mouse L{beta}T2 gonadotropin cells.

Class-C SOX transcription factors control GnRH gene expression via the intronic transcriptional enhancer.

Regulatory roles of heterogeneous nuclear ribonucleoprotein M and Nova-1 protein in alternative splicing of dopamine D2 receptor pre-mRNA.

Insulin contributes to fine-tuning of the pancreatic beta-cell response to glucagon-like peptide-1.

Evolutionarily conserved residues at glucagon-like peptide-1 (GLP-1) receptor core confer ligand-induced receptor activation.

Molecular Coevolution of Neuropeptides Gonadotropin-Releasing Hormone and Kisspeptin with their Cognate G Protein-Coupled Receptors.

Regulation of neurosteroid biosynthesis by neurotransmitters and neuropeptides.

Spatiotemporal expression and functional implication of CXCL14 in the developing mice cerebellum.

Anti-cancer activity of a novel small molecule compound that simultaneously activates p53 and inhibits NF-κB signaling.

CXCL14 enhances proliferation and migration of NCI-H460 human lung cancer cells overexpressing the glycoproteins containing heparan sulfate or sialic acid.

Structural and molecular conservation of glucagon-like Peptide-1 and its receptor confers selective ligand-receptor interaction.

Expansion of secretin-like G protein-coupled receptors and their peptide ligands via local duplications before and after two rounds of whole-genome duplication.

Synchronous activation of gonadotropin-releasing hormone gene transcription and secretion by pulsatile kisspeptin stimulation.

A novel glucagon-related peptide (GCRP) and its receptor GCRPR account for coevolution of their family members in vertebrates.

Natalisin, a tachykinin-like signaling system, regulates sexual activity and fecundity in insects.

Local duplication of gonadotropin-releasing hormone (GnRH) receptor before two rounds of whole genome duplication and origin of the mammalian GnRH receptor.

Coevolution of the spexin/galanin/kisspeptin family: Spexin activates galanin receptor type II and III.

Molecular evolution of GPCRs: GLP1/GLP1 receptors.

Neuropeptide GPCRs in Neuroendocrinology.

Identification of a novel insect neuropeptide, CNMa and its receptor.

A splicing variant of NME1 negatively regulates NF-κB signaling and inhibits cancer metastasis by interacting with IKKβ.

Apoptotic death of prostate cancer cells by a gonadotropin-releasing hormone-II antagonist.

Does Kisspeptin Belong to the Proposed RF-Amide Peptide Family?

A Novel Long-Acting Glucagon-Like Peptide-1 Agonist with Improved Efficacy in Insulin Secretion and β-Cell Growth.

Ligand binding pocket formed by evolutionarily conserved residues in the glucagon-like peptide-1 (GLP-1) receptor core domain.

Histidine(7.36(305)) in the conserved peptide receptor activation domain of the gonadotropin releasing hormone receptor couples peptide binding and receptor activation.

Dimer of arfaptin 2 regulates NF-κB signaling by interacting with IKKβ/NEMO and inhibiting IKKβ kinase activity.

Prevertebrate Local Gene Duplication Facilitated Expansion of the Neuropeptide GPCR Superfamily.

NME1L Negatively Regulates IGF1-Dependent Proliferation of Breast Cancer Cells.

Development of Spexin-based Human Galanin Receptor Type II-Specific Agonists with Increased Stability in Serum and Anxiolytic Effect in Mice.

Characterization of Functional Domains in NME1L Regulation of NF-κB Signaling.

Distribution of galanin receptor 2b neurons and interaction with galanin in the zebrafish central nervous system.

Evolutionary and Comparative Genomics to Drive Rational Drug Design, with Particular Focus on Neuropeptide Seven-Transmembrane Receptors.

GABBR2 mutations determine phenotype in rett syndrome and epileptic encephalopathy.

FAM19A5, a brain-specific chemokine, inhibits RANKL-induced osteoclast formation through formyl peptide receptor 2.

Nafamostat mesilate negatively regulates the metastasis of triple-negative breast cancer cells.

mRNA expression and metabolic regulation of npy and agrp1/2 in the zebrafish brain.

Replacement of the C-terminal Trp-cage of exendin-4 with a fatty acid improves therapeutic utility.

Conformational signatures in β-arrestin2 reveal natural biased agonism at a G-protein-coupled receptor.

Distribution and neuronal circuit of spexin 1/2 neurons in the zebrafish CNS.

SP-8356, a (1S)-(-)-verbenone derivative, exerts in vitro and in vivo anti-breast cancer effects by inhibiting NF-κB signaling.

Spexin-Based Galanin Receptor Type 2 Agonist for Comorbid Mood Disorders and Abnormal Body Weight.