Oleh Khalimonchuk
Department of Biochemistry,
Nebraska Redox Biology Center,
Nebraska Center for Integrated Biomolecular Communication
University of Nebraska
Oleh Khalimonchuk is a Susan J. Rosowski Associate Professor in the Biochemistry Department, University of Nebraska in Lincoln, Nebraska. He is a member of Fred & Pamela Buffett Cancer Center at the University of Nebraska Medical Center in Omaha, Nebraska, and of the University of Utah Center for Iron & Heme Disorders.
He received his undergraduate with honors degree from Ivan Franko National University in Lviv, Ukraine and a Ph.D. degree from the Dresden University of Technology and Max Planck Institute of Cell Biology and Genetics, Germany. After completing postdoctoral training as an American Heart Association fellow with Dr. Dennis Winge at the University of Utah School of Medicine in Salt Lake City, Utah. In 2011, he was recruited as faculty at the University of Nebraska.
Dr. Khalimonchuk’s research uses yeast, roundworm, and mammalian cell culture models and is focused on fundamental understanding of processes behind vital mitochondrial functions and their contribution to aging-associated diseases in humans. His current research interests include the mechanisms of mitochondrial heme transport and the neuroprotective roles of mitochondrial quality control factors. His work received several prestigious awards including Ruth E. Branham Award and Susan J. Rosowski Professorship from the University of Nebraska, and a Maximizing Investigators' Research Award (MIRA) from the NIH.
YCF1-mediated cadmium resistance in yeast is dependent on copper metabolism and antioxidant enzymes.
Antioxidants & redox signaling Oct, 2014 | Pubmed ID: 24444374
Oxidative stress, redox signaling, and autophagy: cell death versus survival.
Antioxidants & redox signaling Jul, 2014 | Pubmed ID: 24483238
Stress-triggered activation of the metalloprotease Oma1 involves its C-terminal region and is important for mitochondrial stress protection in yeast.
The Journal of biological chemistry May, 2014 | Pubmed ID: 24648523
Overexpression of alpha-synuclein at non-toxic levels increases dopaminergic cell death induced by copper exposure via modulation of protein degradation pathways.
Neurobiology of disease Sep, 2015 | Pubmed ID: 25497688
Mitochondrial protein quality control: the mechanisms guarding mitochondrial health.
Antioxidants & redox signaling Apr, 2015 | Pubmed ID: 25546710
Hyaluronidase Hyal1 Increases Tumor Cell Proliferation and Motility through Accelerated Vesicle Trafficking.
The Journal of biological chemistry May, 2015 | Pubmed ID: 25855794
ROS-induced nanotherapeutic approach for ovarian cancer treatment based on the combinatorial effect of photodynamic therapy and DJ-1 gene suppression.
Nanomedicine : nanotechnology, biology, and medicine Nov, 2015 | Pubmed ID: 26238076
Mitochondrial dysfunction and loss of glutamate uptake in primary astrocytes exposed to titanium dioxide nanoparticles.
Nanoscale Nov, 2015 | Pubmed ID: 26274697
Metalloprotease OMA1 Fine-tunes Mitochondrial Bioenergetic Function and Respiratory Supercomplex Stability.
Scientific reports Sep, 2015 | Pubmed ID: 26365306
Inhibition of Protein Ubiquitination by Paraquat and 1-Methyl-4-Phenylpyridinium Impairs Ubiquitin-Dependent Protein Degradation Pathways.
Molecular neurobiology 10, 2016 | Pubmed ID: 26409479
Analysis of Oligomerization Properties of Heme a Synthase Provides Insights into Its Function in Eukaryotes.
The Journal of biological chemistry May, 2016 | Pubmed ID: 26940873
Mitochondrial Quality Control Proteases in Neuronal Welfare.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 12, 2016 | Pubmed ID: 27137937
Mechanistic Nanotherapeutic Approach Based on siRNA-Mediated DJ-1 Protein Suppression for Platinum-Resistant Ovarian Cancer.
Molecular pharmaceutics 06, 2016 | Pubmed ID: 27170529
Glucose Metabolism and AMPK Signaling Regulate Dopaminergic Cell Death Induced by Gene (α-Synuclein)-Environment (Paraquat) Interactions.
Molecular neurobiology 07, 2017 | Pubmed ID: 27324791
Oma1 Links Mitochondrial Protein Quality Control and TOR Signaling To Modulate Physiological Plasticity and Cellular Stress Responses.
Molecular and cellular biology 09, 2016 | Pubmed ID: 27325672
Sending Out an SOS: Mitochondria as a Signaling Hub.
Frontiers in cell and developmental biology , 2016 | Pubmed ID: 27790613
Evidence for Pipecolate Oxidase in Mediating Protection Against Hydrogen Peroxide Stress.
Journal of cellular biochemistry 07, 2017 | Pubmed ID: 27922192
The Assembly Factor Pet117 Couples Heme a Synthase Activity to Cytochrome Oxidase Assembly.
The Journal of biological chemistry 02, 2017 | Pubmed ID: 27998984
Metalloproteases of the Inner Mitochondrial Membrane.
Biochemistry 09, 2017 | Pubmed ID: 28806058
Ydj1 governs fungal morphogenesis and stress response, and facilitates mitochondrial protein import via Mas1 and Mas2.
Microbial cell (Graz, Austria) Oct, 2017 | Pubmed ID: 29082232
Mitochondrial Reactive Oxygen Species in Lipotoxic Hearts Induce Post-Translational Modifications of AKAP121, DRP1, and OPA1 That Promote Mitochondrial Fission.
Circulation research 01, 2018 | Pubmed ID: 29092894
Intraperitoneal nanotherapy for metastatic ovarian cancer based on siRNA-mediated suppression of DJ-1 protein combined with a low dose of cisplatin.
Nanomedicine : nanotechnology, biology, and medicine 06, 2018 | Pubmed ID: 29635082
The AAA ATPase Afg1 preserves mitochondrial fidelity and cellular health by maintaining mitochondrial matrix proteostasis.
Journal of cell science Nov, 2018 | Pubmed ID: 30301782
Proteolytic regulation of mitochondrial dynamics.
Mitochondrion Apr, 2019 | Pubmed ID: 31029640
Redox Regulation of the Mitochondrial Quality Control Protease Oma1.
Antioxidants & redox signaling Aug, 2019 | Pubmed ID: 31044600
ÜBER JoVE
Copyright © 2024 MyJoVE Corporation. Alle Rechte vorbehalten