muscle-velocity-recovery-cycles-to-examine-muscle-membrane-properties

Muscle Velocity Recovery Cycles to Examine Muscle Membrane Properties

Although conventional nerve conduction studies (NCS) and electromyography (EMG) are suitable for the diagnosis of neuromuscular disorders, they provide ...

The National Hospital for Neurology and Neurosurgery

To improve the accuracy of genotype prediction and guide genetic testing in patients with muscle channelopathies we applied and refined specialized electrophysiological exercise test parameters.

Refined exercise testing can aid DNA-based diagnosis in muscle channelopathies.

Myotonia in myotonic dystrophy types 1 (DM1) and 2 (DM2) is generally attributed to reduced chloride-channel conductance. We used muscle velocity recovery cycles (MVRCs) to investigate muscle membrane properties in DM1 and DM2, using comparisons with myotonia congenita (MC).

In vivo assessment of muscle membrane properties in myotonic dystrophy.

The gain-of-function mutations that underlie sodium channel myotonia (SCM) and paramyotonia congenital (PMC) produce differing clinical phenotypes. We used muscle velocity recovery cycles (MVRCs) to investigate membrane properties.

S. Veronica Tan

MRC Centre for Neuromuscular Diseases,
UCL Institute of Neurology,
MRC Centre for Neuromuscular Diseases, UCL Institute of Neurology

The National Hospital for Neurology and Neurosurgery

Muscle Velocity Recovery Cycles to Examine Muscle Membrane Properties

S. Veronica Tan

.css-o250i3{font-size:18px;font-family:Open Sans,sans-serif;line-height:21.6px;}MRC Centre for Neuromuscular Diseases,UCL Institute of Neurology,MRC Centre for Neuromuscular Diseases, UCL Institute of Neurology

The National Hospital for Neurology and Neurosurgery

Muscle Velocity Recovery Cycles to Examine Muscle Membrane Properties

MRC Centre for Neuromuscular Diseases,
UCL Institute of Neurology,
MRC Centre for Neuromuscular Diseases, UCL Institute of Neurology