Biomedical Engineering
Gustav Strijkers is full professor of preclinical and translational MRI at the Department of Biomedical Engineering of Amsterdam University Medical Centers and the University of Amsterdam, in Amsterdam, the Netherlands, and adjunct professor at the BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York . He received a PhD degree in physics from Eindhoven University of Technology in 1999.
His group at Amsterdam University Medical Centers has the ambition to develop novel quantitative and comprehensive MRI techniques with application to important healthcare problems, including cardiovascular diseases and neuromuscular disorders. Gustav Strijkers authored over 250 works and mentored over 30 PhD students.
An MR-compatible device for the in situ assessment of isometric contractile performance of mouse hind-limb ankle flexors.
Pflügers Archiv : European journal of physiology Dec, 2003 | Pubmed ID: 14530976
The use of high-resolution magnetic resonance imaging for monitoring interbody fusion and bioabsorbable cages: an ex vivo pilot study.
Neurosurgical focus Mar, 2004 | Pubmed ID: 15198491
A liposomal system for contrast-enhanced magnetic resonance imaging of molecular targets.
Bioconjugate chemistry Jul-Aug, 2004 | Pubmed ID: 15264867
Determination of mouse skeletal muscle architecture using three-dimensional diffusion tensor imaging.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Jun, 2005 | Pubmed ID: 15906281
MR molecular imaging and fluorescence microscopy for identification of activated tumor endothelium using a bimodal lipidic nanoparticle.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Dec, 2005 | Pubmed ID: 16204353
Quantum dots with a paramagnetic coating as a bimodal molecular imaging probe.
Nano letters Jan, 2006 | Pubmed ID: 16402777
Lipid-based nanoparticles for contrast-enhanced MRI and molecular imaging.
NMR in biomedicine Feb, 2006 | Pubmed ID: 16450332
MRI-guided immunotherapy development for multiple sclerosis in a primate.
Drug discovery today Jan, 2006 | Pubmed ID: 16478692
Liposome-enhanced MRI of neointimal lesions in the ApoE-KO mouse.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine May, 2006 | Pubmed ID: 16598732
Annexin A5-functionalized bimodal lipid-based contrast agents for the detection of apoptosis.
Bioconjugate chemistry May-Jun, 2006 | Pubmed ID: 16704213
DTI-based assessment of ischemia-reperfusion in mouse skeletal muscle.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Aug, 2006 | Pubmed ID: 16826605
Annexin A5-conjugated quantum dots with a paramagnetic lipidic coating for the multimodal detection of apoptotic cells.
Bioconjugate chemistry Jul-Aug, 2006 | Pubmed ID: 16848390
Dynamic MRS and MRI of skeletal muscle function and biomechanics.
NMR in biomedicine Nov, 2006 | Pubmed ID: 17075956
Comparison between prospective and retrospective triggering for mouse cardiac MRI.
NMR in biomedicine Jun, 2007 | Pubmed ID: 17120296
Early in vivo assessment of angiostatic therapy efficacy by molecular MRI.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Feb, 2007 | Pubmed ID: 17202248
Role of ischemia and deformation in the onset of compression-induced deep tissue injury: MRI-based studies in a rat model.
Journal of applied physiology (Bethesda, Md. : 1985) May, 2007 | Pubmed ID: 17255369
Skeletal muscle degeneration and regeneration after femoral artery ligation in mice: monitoring with diffusion MR imaging.
Radiology May, 2007 | Pubmed ID: 17384238
Sterilization and strength of 70/30 polylactide cages: e-beam versus ethylene oxide.
Spine Apr, 2007 | Pubmed ID: 17414907
MRI contrast agents: current status and future perspectives.
Anti-cancer agents in medicinal chemistry May, 2007 | Pubmed ID: 17504156
多模态成像的磁性和荧光纳米颗粒。
Nanomedicine (London, England) Jun, 2007 | Pubmed ID: 17716176
Magnetic resonance molecular imaging contrast agents and their application in atherosclerosis.
Topics in magnetic resonance imaging : TMRI Oct, 2007 | Pubmed ID: 18025995
Molecular imaging of macrophages in atherosclerotic plaques using bimodal PEG-micelles.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Dec, 2007 | Pubmed ID: 18046703
Evaluation of manual and automatic segmentation of the mouse heart from CINE MR images.
Journal of magnetic resonance imaging : JMRI Jan, 2008 | Pubmed ID: 18050352
Fast progression of recombinant human myelin/oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis in marmosets is associated with the activation of MOG34-56-specific cytotoxic T cells.
Journal of immunology (Baltimore, Md. : 1950) Feb, 2008 | Pubmed ID: 18209026
Smoothelin-B deficiency results in reduced arterial contractility, hypertension, and cardiac hypertrophy in mice.
Circulation Aug, 2008 | Pubmed ID: 18678771
Short- and long-term limbic abnormalities after experimental febrile seizures.
Neurobiology of disease Nov, 2008 | Pubmed ID: 18707002
Diffusion tensor imaging of left ventricular remodeling in response to myocardial infarction in the mouse.
NMR in biomedicine Feb, 2009 | Pubmed ID: 18780284
A high relaxivity Gd(III)DOTA-DSPE-based liposomal contrast agent for magnetic resonance imaging.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V Jun, 2009 | Pubmed ID: 18940253
Kinetics of avidin-induced clearance of biotinylated bimodal liposomes for improved MR molecular imaging.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Dec, 2008 | Pubmed ID: 19025910
Paramagnetic lipid-coated silica nanoparticles with a fluorescent quantum dot core: a new contrast agent platform for multimodality imaging.
Bioconjugate chemistry Dec, 2008 | Pubmed ID: 19035793
Improved magnetic resonance molecular imaging of tumor angiogenesis by avidin-induced clearance of nonbound bimodal liposomes.
Neoplasia (New York, N.Y.) Dec, 2008 | Pubmed ID: 19048124
Molecular imaging of tumor angiogenesis using alphavbeta3-integrin targeted multimodal quantum dots.
Angiogenesis , 2009 | Pubmed ID: 19067197
Quantification of left ventricular volumes and ejection fraction in mice using PET, compared with MRI.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine Jan, 2009 | Pubmed ID: 19091898
Internalization of annexin A5-functionalized iron oxide particles by apoptotic Jurkat cells.
Contrast media & molecular imaging Jan-Feb, 2009 | Pubmed ID: 19137542
Three-compartment T1 relaxation model for intracellular paramagnetic contrast agents.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine May, 2009 | Pubmed ID: 19215042
Cellular compartmentalization of internalized paramagnetic liposomes strongly influences both T1 and T2 relaxivity.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine May, 2009 | Pubmed ID: 19235908
On the use of steady-state signal equations for 2D TrueFISP imaging.
Magnetic resonance imaging Jul, 2009 | Pubmed ID: 19249169
Nanoparticulate assemblies of amphiphiles and diagnostically active materials for multimodality imaging.
Accounts of chemical research Jul, 2009 | Pubmed ID: 19435319
Chitosan-based systems for molecular imaging.
Advanced drug delivery reviews Jan, 2010 | Pubmed ID: 19861142
Diffusion of water in skeletal muscle tissue is not influenced by compression in a rat model of deep tissue injury.
Journal of biomechanics Feb, 2010 | Pubmed ID: 19897200
Synergistic targeting of alphavbeta3 integrin and galectin-1 with heteromultivalent paramagnetic liposomes for combined MR imaging and treatment of angiogenesis.
Nano letters Jan, 2010 | Pubmed ID: 19968235
Magnetic quantum dots for multimodal imaging.
Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Sep-Oct, 2009 | Pubmed ID: 20049812
Current applications of nanotechnology for magnetic resonance imaging of apoptosis.
Methods in molecular biology (Clifton, N.J.) , 2010 | Pubmed ID: 20217606
MRI-determined carotid artery flow velocities and wall shear stress in a mouse model of vulnerable and stable atherosclerotic plaque.
Magma (New York, N.Y.) Apr, 2010 | Pubmed ID: 20229088
Paramagnetic and fluorescent liposomes for target-specific imaging and therapy of tumor angiogenesis.
Angiogenesis Jun, 2010 | Pubmed ID: 20390447
Quantum dots for multimodal molecular imaging of angiogenesis.
Angiogenesis Jun, 2010 | Pubmed ID: 20552267
Quantitative (1)H MRI, (19)F MRI, and (19)F MRS of cell-internalized perfluorocarbon paramagnetic nanoparticles.
Contrast media & molecular imaging Jan-Feb, 2011 | Pubmed ID: 20648660
Reproducibility of diffusion tensor imaging in human forearm muscles at 3.0 T in a clinical setting.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Oct, 2010 | Pubmed ID: 20725932
Surface modification of PLGA nanospheres with Gd-DTPA and Gd-DOTA for high-relaxivity MRI contrast agents.
Biomaterials Nov, 2010 | Pubmed ID: 20797782
Annexin A5-functionalized bimodal nanoparticles for MRI and fluorescence imaging of atherosclerotic plaques.
Bioconjugate chemistry Oct, 2010 | Pubmed ID: 20804153
Contrast enhancement by differently sized paramagnetic MRI contrast agents in mice with two phenotypes of atherosclerotic plaque.
Contrast media & molecular imaging Jan-Feb, 2011 | Pubmed ID: 20882509
Mouse myocardial first-pass perfusion MR imaging.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Dec, 2010 | Pubmed ID: 20928892
Dynamic changes in 1H-MR relaxometric properties of cell-internalized paramagnetic liposomes, as studied over a five-day period.
Contrast media & molecular imaging Mar-Apr, 2011 | Pubmed ID: 20936712
Three-dimensional T1 mapping of the mouse heart using variable flip angle steady-state MR imaging.
NMR in biomedicine Feb, 2011 | Pubmed ID: 20960583
Photochemical activation of endosomal escape of MRI-Gd-agents in tumor cells.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Jan, 2011 | Pubmed ID: 21053327
The binding of CNA35 contrast agents to collagen fibrils.
Chemical communications (Cambridge, England) Feb, 2011 | Pubmed ID: 21088778
Anti-tumor activity of liposomal glucocorticoids: The relevance of liposome-mediated drug delivery, intratumoral localization and systemic activity.
Journal of controlled release : official journal of the Controlled Release Society Apr, 2011 | Pubmed ID: 21130819
Multi-parametric assessment of the anti-angiogenic effects of liposomal glucocorticoids.
Angiogenesis May, 2011 | Pubmed ID: 21225337
The effects of deformation, ischemia, and reperfusion on the development of muscle damage during prolonged loading.
Journal of applied physiology (Bethesda, Md. : 1985) Jul, 2011 | Pubmed ID: 21757578
Target-specific paramagnetic and superparamagnetic micelles for molecular MR imaging.
Methods in molecular biology (Clifton, N.J.) , 2011 | Pubmed ID: 21874503
Regional contrast agent quantification in a mouse model of myocardial infarction using 3D cardiac T1 mapping.
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance , 2011 | Pubmed ID: 21974927
Dual-targeting of α(v)β(3) and galectin-1 improves the specificity of paramagnetic/fluorescent liposomes to tumor endothelium in vivo.
Journal of controlled release : official journal of the Controlled Release Society Oct, 2011 | Pubmed ID: 22079810
In vivo characterization of a new abdominal aortic aneurysm mouse model with conventional and molecular magnetic resonance imaging.
Journal of the American College of Cardiology Dec, 2011 | Pubmed ID: 22133853
Contrast-enhanced MRI of murine myocardial infarction - Part I.
NMR in biomedicine Feb, 2012 | Pubmed ID: 22308108
Molecular MRI of Inflammation in Atherosclerosis.
Current cardiovascular imaging reports Feb, 2012 | Pubmed ID: 22308200
Contrast-enhanced MRI of murine myocardial infarction - Part II.
NMR in biomedicine Feb, 2012 | Pubmed ID: 22311260
Quantitative T (2) (*) assessment of acute and chronic myocardial ischemia/reperfusion injury in mice.
Magma (New York, N.Y.) Feb, 2012 | Pubmed ID: 22327962
Diffusion-tensor MRI reveals the complex muscle architecture of the human forearm.
Journal of magnetic resonance imaging : JMRI Feb, 2012 | Pubmed ID: 22334539
Multiparametric MRI analysis for the identification of high intensity focused ultrasound-treated tumor tissue.
PloS one , 2014 | Pubmed ID: 24927280
A novel approach to tracer-kinetic modeling for (macromolecular) dynamic contrast-enhanced MRI.
Magnetic resonance in medicine Mar, 2016 | Pubmed ID: 25846802
MRI methods for the evaluation of high intensity focused ultrasound tumor treatment: Current status and future needs.
Magnetic resonance in medicine Jan, 2016 | Pubmed ID: 26096859
Multiparametric MRI analysis for the evaluation of MR-guided high intensity focused ultrasound tumor treatment.
NMR in biomedicine Sep, 2015 | Pubmed ID: 26198899
In vivo mouse myocardial (31)P MRS using three-dimensional image-selected in vivo spectroscopy (3D ISIS): technical considerations and biochemical validations.
NMR in biomedicine Oct, 2015 | Pubmed ID: 26269430
Small animal cardiovascular MR imaging and spectroscopy.
Progress in nuclear magnetic resonance spectroscopy Aug, 2015 | Pubmed ID: 26282195
Cluster analysis of DCE-MRI data identifies regional tracer-kinetic changes after tumor treatment with high intensity focused ultrasound.
NMR in biomedicine Nov, 2015 | Pubmed ID: 26390040
Novel axolotl cardiac function analysis method using magnetic resonance imaging.
PloS one , 2017 | Pubmed ID: 28837595
3D Fiber Orientation in Atherosclerotic Carotid Plaques.
Journal of structural biology 10, 2017 | Pubmed ID: 28838817
Human Cardiac P-MR Spectroscopy at 3 Tesla Cannot Detect Failing Myocardial Energy Homeostasis during Exercise.
Frontiers in physiology , 2017 | Pubmed ID: 29230178
Improved Evaluation of Antivascular Cancer Therapy Using Constrained Tracer-Kinetic Modeling for Multiagent Dynamic Contrast-Enhanced MRI.
Cancer research 03, 2018 | Pubmed ID: 29317433
Quantitative MRI in early intervertebral disc degeneration: T1rho correlates better than T2 and ADC with biomechanics, histology and matrix content.
PloS one , 2018 | Pubmed ID: 29381716
Three-dimensional diffusion imaging with spiral encoded navigators from stimulated echoes (3D-DISPENSE).
Magnetic resonance in medicine 02, 2019 | Pubmed ID: 30257041
Inhibiting Inflammation with Myeloid Cell-Specific Nanobiologics Promotes Organ Transplant Acceptance.
Immunity 11, 2018 | Pubmed ID: 30413362
Regional assessment of carotid artery pulse wave velocity using compressed sensing accelerated high temporal resolution 2D CINE phase contrast cardiovascular magnetic resonance.
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 12, 2018 | Pubmed ID: 30567566
Crossing muscle fibers of the human tongue resolved in vivo using constrained spherical deconvolution.
Journal of magnetic resonance imaging : JMRI 07, 2019 | Pubmed ID: 30648339
Exploration of New Contrasts, Targets, and MR Imaging and Spectroscopy Techniques for Neuromuscular Disease - A Workshop Report of Working Group 3 of the Biomedicine and Molecular Biosciences COST Action BM1304 MYO-MRI.
Journal of neuromuscular diseases , 2019 | Pubmed ID: 30714967
Comparison of four MR carotid surface coils at 3T.
PloS one , 2019 | Pubmed ID: 30830934
There is an individual tolerance to mechanical loading in compression induced deep tissue injury.
Clinical biomechanics (Bristol, Avon) 03, 2019 | Pubmed ID: 30897463
Emerging Magnetic Resonance Imaging Techniques for Atherosclerosis Imaging.
Arteriosclerosis, thrombosis, and vascular biology 05, 2019 | Pubmed ID: 30917678
An iterative sparse deconvolution method for simultaneous multicolor F-MRI of multiple contrast agents.
Magnetic resonance in medicine 01, 2020 | Pubmed ID: 31441541
An isolated beating pig heart platform for a comprehensive evaluation of intracardiac blood flow with 4D flow MRI: a feasibility study.
European radiology experimental 10, 2019 | Pubmed ID: 31650367
The repeatability of bilateral diffusion tensor imaging (DTI) in the upper leg muscles of healthy adults.
European radiology Mar, 2020 | Pubmed ID: 31705253
Rapid stromal remodeling by short-term VEGFR2 inhibition increases chemotherapy delivery in esophagogastric adenocarcinoma.
Molecular oncology , | Pubmed ID: 31733011
Diagnostic accuracy of MRI and ultrasound in chronic immune-mediated neuropathies.
Neurology 01, 2020 | Pubmed ID: 31827006
Compressed sensing MRI with variable density averaging (CS-VDA) outperforms full sampling at low SNR.
Physics in medicine and biology 02, 2020 | Pubmed ID: 31851959
A 12-channel flexible receiver coil for accelerated tongue imaging.
Magma (New York, N.Y.) Aug, 2020 | Pubmed ID: 31950389
Pseudo-spiral sampling and compressed sensing reconstruction provides flexibility of temporal resolution in accelerated aortic 4D flow MRI: A comparison with k-t principal component analysis.
NMR in biomedicine 04, 2020 | Pubmed ID: 31957927
Highly accelerated 4D flow cardiovascular magnetic resonance using a pseudo-spiral Cartesian acquisition and compressed sensing reconstruction for carotid flow and wall shear stress.
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 01, 2020 | Pubmed ID: 31959203
Locally advanced rectal cancer: 3D diffusion-prepared stimulated-echo turbo spin-echo versus 2D diffusion-weighted echo-planar imaging.
European radiology experimental 02, 2020 | Pubmed ID: 32030561
Acute cellular and vascular responses to photodynamic therapy using EGFR-targeted nanobody-photosensitizer conjugates studied with intravital optical imaging and magnetic resonance imaging.
Theranostics , 2020 | Pubmed ID: 32089747
Quantitative MRI Reveals Microstructural Changes in the Upper Leg Muscles After Running a Marathon.
Journal of magnetic resonance imaging : JMRI 08, 2020 | Pubmed ID: 32144857
Probing myeloid cell dynamics in ischaemic heart disease by nanotracer hot-spot imaging.
Nature nanotechnology May, 2020 | Pubmed ID: 32313216
Subclinical effects of long-chain fatty acid β-oxidation deficiency on the adult heart: A case-control magnetic resonance study.
Journal of inherited metabolic disease 09, 2020 | Pubmed ID: 32463482
Altered brain fluid management in a rat model of arterial hypertension.
Fluids and barriers of the CNS Jun, 2020 | Pubmed ID: 32590994
Marathon running transiently depletes the myocardial lipid pool.
Physiological reports 09, 2020 | Pubmed ID: 32869950
Supervised segmentation framework for evaluation of diffusion tensor imaging indices in skeletal muscle.
NMR in biomedicine 01, 2021 | Pubmed ID: 33001508
Predicting Poor Outcome Before Endovascular Treatment in Patients With Acute Ischemic Stroke.
Frontiers in neurology , 2020 | Pubmed ID: 33178123
Ultra-high resolution, 3-dimensional magnetic resonance imaging of the atherosclerotic vessel wall at clinical 7T.
PloS one , 2020 | Pubmed ID: 33315867
Quantification of Myocardial Creatine and Triglyceride Content in the Human Heart: Precision and Accuracy of in vivo Proton Magnetic Resonance Spectroscopy.
Journal of magnetic resonance imaging : JMRI Feb, 2021 | Pubmed ID: 33569824
Iron Oxide Nanoparticle Uptake in Mouse Brachiocephalic Artery Atherosclerotic Plaque Quantified by T-Mapping MRI.
Pharmaceutics Feb, 2021 | Pubmed ID: 33669667
The Antibiotic Doxycycline Impairs Cardiac Mitochondrial and Contractile Function.
International journal of molecular sciences Apr, 2021 | Pubmed ID: 33921053
Mariah R. R. Daal1,
Gustav J. Strijkers1,2,
Claudia Calcagno2,
Ruslan R. Garipov3,
Rob C. I. Wüst1,4,
David Hautemann5,
Bram F. Coolen1
1Department of Biomedical Engineering & Physics, Amsterdam University Medical Centers, Amsterdam Cardiovascular Sciences, University of Amsterdam,
2BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai,
3, MR Solutions Ltd.,
4Laboratory for Myology, Department of Human Movement Sciences, Faculty of Behavioral and Movement Sciences, Vrije Universiteit Amsterdam,
5, Medis medical imaging systems B.V.
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