Paul C. Evans

A novel type of deubiquitinating enzyme.

Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity.

Regulation of pro-inflammatory signalling networks by ubiquitin: identification of novel targets for anti-inflammatory drugs.

The triage of damaged proteins: degradation by the ubiquitin-proteasome pathway or repair by molecular chaperones.

Laminar shear stress acts as a switch to regulate divergent functions of NF-kappaB in endothelial cells.

Effect of shear stress on vascular inflammation and plaque development.

NF-kappaB suppression by the deubiquitinating enzyme Cezanne: a novel negative feedback loop in pro-inflammatory signaling.

KLF2-dependent, shear stress-induced expression of CD59: a novel cytoprotective mechanism against complement-mediated injury in the vasculature.

Elevated p53 expression is associated with dysregulation of the ubiquitin-proteasome system in dilated cardiomyopathy.

Hydrogen peroxide prolongs nuclear localization of NF-kappaB in activated cells by suppressing negative regulatory mechanisms.

Increased endothelial mitogen-activated protein kinase phosphatase-1 expression suppresses proinflammatory activation at sites that are resistant to atherosclerosis.

Hemodynamic parameters regulating vascular inflammation and atherosclerosis: a brief update.

The A20 gene protects kidneys from ischaemia/reperfusion injury by suppressing pro-inflammatory activation.

Nur77: orphaned at birth but adopted by the nuclear factor kappaB signaling pathway.

Induction of the cytoprotective enzyme heme oxygenase-1 by statins is enhanced in vascular endothelium exposed to laminar shear stress and impaired by disturbed flow.

Activation of Nrf2 in endothelial cells protects arteries from exhibiting a proinflammatory state.

Perfusion of veins at arterial pressure increases the expression of KLF5 and cell cycle genes in smooth muscle cells.

c-Jun N-terminal kinase primes endothelial cells at atheroprone sites for apoptosis.

Celecoxib activates PI-3K/Akt and mitochondrial redox signaling to enhance heme oxygenase-1-mediated anti-inflammatory activity in vascular endothelium.

Role of nuclear factor kappaB in cardiovascular health and disease.

Smooth muscle cells in porcine vein graft intimal hyperplasia are derived from the local vessel wall.

Inhibition of NF-κB signaling in human dendritic cells by the enteropathogenic Escherichia coli effector protein NleE.

The transcription factor Erg inhibits vascular inflammation by repressing NF-kappaB activation and proinflammatory gene expression in endothelial cells.

Dexamethasone arterializes venous endothelial cells by inducing mitogen-activated protein kinase phosphatase-1: a novel antiinflammatory treatment for vein grafts?

Do miniaturized extracorporeal circuits confer significant clinical benefit without compromising safety? A meta-analysis of randomized controlled trials.

Disturbed blood flow induces RelA expression via c-Jun N-terminal kinase 1: a novel mode of NF-κB regulation that promotes arterial inflammation.

The role of blood flow in determining the sites of atherosclerotic plaques.

Heme induces heme oxygenase 1 via Nrf2: role in the homeostatic macrophage response to intraplaque hemorrhage.

Targeting inhibitor of apoptosis proteins to block vascular inflammation.