Renjie Chai

Dynamic expression of Lgr5, a Wnt target gene, in the developing and mature mouse cochlea.

Spontaneous hair cell regeneration in the neonatal mouse cochlea in vivo.

Ildr1b is essential for semicircular canal development, migration of the posterior lateral line primordium and hearing ability in zebrafish: implications for a role in the recessive hearing impairment DFNB42.

In vivo overexpression of X-linked inhibitor of apoptosis protein protects against neomycin-induced hair cell loss in the apical turn of the cochlea during the ototoxic-sensitive period.

Combining use of captopril and losartan attenuates the progress of Streptococcus pneumoniae-induced tympanosclerosis through the suppression of TGF-β1 expression.

Notch inhibition induces mitotically generated hair cells in mammalian cochleae via activating the Wnt pathway.

MiRNA-320 in the human follicular fluid is associated with embryo quality in vivo and affects mouse embryonic development in vitro.

Lgr5+ cells regenerate hair cells via proliferation and direct transdifferentiation in damaged neonatal mouse utricle.

LSD1 is Required for Hair Cell Regeneration in Zebrafish.

Effects of local application of methylprednisolone delivered by the C/GP-hydrogel on the recovery of facial nerves.

HDAC3 Is Required for Posterior Lateral Line Development in Zebrafish.

Mutations in TUBB8 and Human Oocyte Meiotic Arrest.

MicroRNA-10a/10b represses a novel target gene mib1 to regulate angiogenesis.

Histone deacetylase 1 is required for the development of the zebrafish inner ear.

Bmi1 Regulates the Proliferation of Cochlear Supporting Cells Via the Canonical Wnt Signaling Pathway.

The Three-Dimensional Culture System with Matrigel and Neurotrophic Factors Preserves the Structure and Function of Spiral Ganglion Neuron In Vitro.

Characterization of Lgr5+ progenitor cell transcriptomes in the apical and basal turns of the mouse cochlea.

Regeneration of hair cells in the mammalian vestibular system.

The structural development of primary cultured hippocampal neurons on a graphene substrate.

Reduced TRMU expression increases the sensitivity of hair-cell-like HEI-OC-1 cells to neomycin damage in vitro.

Co-regulation of the Notch and Wnt signaling pathways promotes supporting cell proliferation and hair cell regeneration in mouse utricles.

Spatiotemporal expression of Ezh2 in the developing mouse cochlear sensory epithelium.

Role of Wnt and Notch signaling in regulating hair cell regeneration in the cochlea.

Extensive Supporting Cell Proliferation and Mitotic Hair Cell Generation by In Vivo Genetic Reprogramming in the Neonatal Mouse Cochlea.

Inhibition of ARC decreases the survival of HEI-OC-1 cells after neomycin damage in vitro.

Wnt activation followed by Notch inhibition promotes mitotic hair cell regeneration in the postnatal mouse cochlea.

Accelerating bioelectric functional development of neural stem cells by graphene coupling: Implications for neural interfacing with conductive materials.

MiR-182-5p protects inner ear hair cells from cisplatin-induced apoptosis by inhibiting FOXO3a.

The somite-secreted factor Maeg promotes zebrafish embryonic angiogenesis.

c-Myb knockdown increases the neomycin-induced damage to hair-cell-like HEI-OC1 cells in vitro.

A Three-Dimensional Culture System with Matrigel Promotes Purified Spiral Ganglion Neuron Survival and Function In Vitro.

Hearing Loss: Reestablish the Neural Plasticity in Regenerated Spiral Ganglion Neurons and Sensory Hair Cells.

Targeting HSP90-HDAC6 Regulating Network Implicates Precision Treatment of Breast Cancer.

An episomal vector-based CRISPR/Cas9 system for highly efficient gene knockout in human pluripotent stem cells.

Bone morphogenetic protein 4 promotes the survival and preserves the structure of flow-sorted Bhlhb5+ cochlear spiral ganglion neurons in vitro.

Inactivation of STAT3 Signaling Impairs Hair Cell Differentiation in the Developing Mouse Cochlea.

Auditory Neuropathy after Damage to Cochlear Spiral Ganglion Neurons in Mice Resulting from Conditional Expression of Diphtheria Toxin Receptors.

Is Required for Zebrafish Posterior Lateral Line Development.

Insm1a Regulates Motor Neuron Development in Zebrafish.

Autophagy protects auditory hair cells against neomycin-induced damage.

Loss of CIB2 Causes Profound Hearing Loss and Abolishes Mechanoelectrical Transduction in Mice.

Hedgehog Signaling Promotes the Proliferation and Subsequent Hair Cell Formation of Progenitor Cells in the Neonatal Mouse Cochlea.

Looking into the Future: Toward Advanced 3D Biomaterials for Stem-Cell-Based Regenerative Medicine.

Wnt Signaling Activates TP53-Induced Glycolysis and Apoptosis Regulator and Protects Against Cisplatin-Induced Spiral Ganglion Neuron Damage in the Mouse Cochlea.

Characterization of Wnt and Notch-Responsive Lgr5+ Hair Cell Progenitors in the Striolar Region of the Neonatal Mouse Utricle.

Characterization of Lgr6+ Cells as an Enriched Population of Hair Cell Progenitors Compared to Lgr5+ Cells for Hair Cell Generation in the Neonatal Mouse Cochlea.

Meclofenamic Acid Reduces Reactive Oxygen Species Accumulation and Apoptosis, Inhibits Excessive Autophagy, and Protects Hair Cell-Like HEI-OC1 Cells From Cisplatin-Induced Damage.

Real-Time Multimodal Bioimaging of Cancer Cells and Exosomes through Biosynthesized Iridium and Iron Nanoclusters.

Hoxc-Dependent Mesenchymal Niche Heterogeneity Drives Regional Hair Follicle Regeneration.

Tuberous sclerosis complex-mediated mTORC1 overactivation promotes age-related hearing loss.

Loss of ARHGEF6 Causes Hair Cell Stereocilia Deficits and Hearing Loss in Mice.

The role of FOXG1 in the postnatal development and survival of mouse cochlear hair cells.

Author Correction: An episomal vector-based CRISPR/Cas9 system for highly efficient gene knockout in human pluripotent stem cells.

Surgery-free video-oculography in mouse models: enabling quantitative and short-interval longitudinal assessment of vestibular function.

Designs of Biomaterials and Microenvironments for Neuroengineering.

Hearing Loss: Reestablish the Neural Plasticity in Regenerated Spiral Ganglion Neurons and Sensory Hair Cells 2018.

Transduction of Adeno-Associated Virus Vectors Targeting Hair Cells and Supporting Cells in the Neonatal Mouse Cochlea.

A cytoskeleton structure revealed by super-resolution fluorescence imaging in inner ear hair cells.

Novel compounds protect auditory hair cells against gentamycin-induced apoptosis by maintaining the expression level of H3K4me2.

Deletion of Limk1 and Limk2 in mice does not alter cochlear development or auditory function.

Hair Cell Regeneration.

Protection of Hair Cells from Ototoxic Drug-Induced Hearing Loss.

Critical role of spectrin in hearing development and deafness.

A humanized mouse model, demonstrating progressive hearing loss caused by MYO6 p.C442Y, is inherited in a semi-dominant pattern.

Transcriptomic profiling of neural stem cell differentiation on graphene substrates.

The application of graphene-based biomaterials in biomedicine.

TeraVR empowers precise reconstruction of complete 3-D neuronal morphology in the whole brain.

Structurally Tunable Reduced Graphene Oxide Substrate Maintains Mouse Embryonic Stem Cell Pluripotency.

AAV-ie enables safe and efficient gene transfer to inner ear cells.

Frizzled-9+ Supporting Cells Are Progenitors for the Generation of Hair Cells in the Postnatal Mouse Cochlea.

Laminin-Coated Electrospun Regenerated Silk Fibroin Mats Promote Neural Progenitor Cell Proliferation, Differentiation, and Survival .

Knockdown of Foxg1 in supporting cells increases the trans-differentiation of supporting cells into hair cells in the neonatal mouse cochlea.

Stress-Induced Metabolic Disorder in Peripheral CD4 T Cells Leads to Anxiety-like Behavior.