Karen S. Wilcox

Effects of the anticonvulsant retigabine on cultured cortical neurons: changes in electroresponsive properties and synaptic transmission.

Evidence for functionally distinct synaptic NMDA receptors in ventromedial versus dorsolateral striatum.

Characterization of the anticonvulsant profile and enantioselective pharmacokinetics of the chiral valproylamide propylisopropyl acetamide in rodents.

The effect of CGX-1007 and CI-1041, novel NMDA receptor antagonists, on NMDA receptor-mediated EPSCs.

Mice carrying the szt1 mutation exhibit increased seizure susceptibility and altered sensitivity to compounds acting at the m-channel.

A spontaneous mutation involving Kcnq2 (Kv7.2) reduces M-current density and spike frequency adaptation in mouse CA1 neurons.

Subunit selectivity of topiramate modulation of heteromeric GABA(A) receptors.

Effect of Conantokin G on NMDA receptor-mediated spontaneous EPSCs in cultured cortical neurons.

A rat brain slice preparation for characterizing both thalamostriatal and corticostriatal afferents.

Felbamate is a subunit selective modulator of recombinant gamma-aminobutyric acid type A receptors expressed in Xenopus oocytes.

Discovery of antiepileptic drugs.

Differential contribution of kainate receptors to excitatory postsynaptic currents in superficial layer neurons of the rat medial entorhinal cortex.

Phenytoin- and carbamazepine-resistant spontaneous bursting in rat entorhinal cortex is blocked by retigabine in vitro.

Mechanisms of action of antiepileptic drugs.

Inhibition of the betaine-GABA transporter (mGAT2/BGT-1) modulates spontaneous electrographic bursting in the medial entorhinal cortex (mEC).

Seizures following picornavirus infection.

Mouse models of human KCNQ2 and KCNQ3 mutations for benign familial neonatal convulsions show seizures and neuronal plasticity without synaptic reorganization.

Differences in excitatory transmission between thalamic and cortical afferents to single spiny efferent neurons of rat dorsal striatum.

Electroconvulsive seizure thresholds and kindling acquisition rates are altered in mouse models of human KCNQ2 and KCNQ3 mutations for benign familial neonatal convulsions.

Innate but not adaptive immune responses contribute to behavioral seizures following viral infection.

Theiler's virus infection chronically alters seizure susceptibility.

Role for complement in the development of seizures following acute viral infection.

Development of postinfection epilepsy after Theiler's virus infection of C57BL/6 mice.

CGX-1007 prevents excitotoxic cell death via actions at multiple types of NMDA receptors.

Topiramate modulation of β(1)- and β(3)-homomeric GABA(A) receptors.

Interleukin-6, produced by resident cells of the central nervous system and infiltrating cells, contributes to the development of seizures following viral infection.

cAMP-dependent protein kinase A activity modulates topiramate potentiation of GABA(A) receptors.

Lack of correlation of central nervous system inflammation and neuropathology with the development of seizures following acute virus infection.

Once initiated, viral encephalitis-induced seizures are consistent no matter the treatment or lack of interleukin-6.

Altered learning and Arc-regulated consolidation of learning in striatum by methamphetamine-induced neurotoxicity.

A new derivative of valproic acid amide possesses a broad-spectrum antiseizure profile and unique activity against status epilepticus and organophosphate neuronal damage.

The activity within the CA3 excitatory network during Theiler's virus encephalitis is distinct from that observed during chronic epilepsy.

Rapid loss of efficacy to the antiseizure drugs lamotrigine and carbamazepine: a novel experimental model of pharmacoresistant epilepsy.

Issues related to development of new antiseizure treatments.

The expression of kainate receptor subunits in hippocampal astrocytes after experimentally induced status epilepticus.

Novel, broad-spectrum anticonvulsants containing a sulfamide group: pharmacological properties of (S)-N-[(6-chloro-2,3-dihydrobenzo[1,4]dioxin-2-yl)methyl]sulfamide (JNJ-26489112).

Impaired cognitive ability and anxiety-like behavior following acute seizures in the Theiler's virus model of temporal lobe epilepsy.

Antiseizure drugs differentially modulate θ-burst induced long-term potentiation in C57BL/6 mice.

Does brain inflammation mediate pathological outcomes in epilepsy?

The challenge and promise of anti-epileptic therapy development in animal models.

Imaging activity in neurons and glia with a Polr2a-based and cre-dependent GCaMP5G-IRES-tdTomato reporter mouse.

Evaluating an etiologically relevant platform for therapy development for temporal lobe epilepsy: effects of carbamazepine and valproic acid on acute seizures and chronic behavioral comorbidities in the Theiler's murine encephalomyelitis virus mouse model.

Imaging activity in astrocytes and neurons with genetically encoded calcium indicators following in utero electroporation.

Oxidative stress in murine Theiler's virus-induced temporal lobe epilepsy.

Altered structure and function of astrocytes following status epilepticus.

Repeated low-dose kainate administration in C57BL/6J mice produces temporal lobe epilepsy pathology but infrequent spontaneous seizures.

Neuronal Injury, Gliosis, and Glial Proliferation in Two Models of Temporal Lobe Epilepsy.

NBQX, a highly selective competitive antagonist of AMPA and KA ionotropic glutamate receptors, increases seizures and mortality following picornavirus infection.

Acute treatment with minocycline, but not valproic acid, improves long-term behavioral outcomes in the Theiler's virus model of temporal lobe epilepsy.

Validation of a Preclinical Drug Screening Platform for Pharmacoresistant Epilepsy.

Development and pharmacologic characterization of the rat 6 Hz model of partial seizures.

Evaluation of Cannabidiol in Animal Seizure Models by the Epilepsy Therapy Screening Program (ETSP).

Hippocampal TNFα Signaling Contributes to Seizure Generation in an Infection-Induced Mouse Model of Limbic Epilepsy.

Preclinical Comparison of Mechanistically Different Antiseizure, Antinociceptive, and/or Antidepressant Drugs in a Battery of Rodent Models of Nociceptive and Neuropathic Pain.

Corneal kindled C57BL/6 mice exhibit saturated dentate gyrus long-term potentiation and associated memory deficits in the absence of overt neuron loss.

Epilepsy as a Network Disorder (2): What can we learn from other network disorders such as dementia and schizophrenia, and what are the implications for translational research?

Novel Targets for Developing Antiseizure and, Potentially, Antiepileptogenic Drugs.

Recurrent epileptiform discharges in the medial entorhinal cortex of kainate-treated rats are differentially sensitive to antiseizure drugs.

Conditional Knock-out of mGluR5 from Astrocytes during Epilepsy Development Impairs High-Frequency Glutamate Uptake.

Genetic and pharmacological manipulation of glial glutamate transporters does not alter infection-induced seizure activity.

Cannabidiol reduces seizures following CNS infection with Theiler's murine encephalomyelitis virus.

Evaluation of antiseizure drug efficacy and tolerability in the rat lamotrigine-resistant amygdala kindling model.

The current approach of the Epilepsy Therapy Screening Program contract site for identifying improved therapies for the treatment of pharmacoresistant seizures in epilepsy.

Ultrastructural and functional changes at the tripartite synapse during epileptogenesis in a model of temporal lobe epilepsy.

Discovery of the First Vitamin K Analogue as a Potential Treatment of Pharmacoresistant Seizures.

Evaluation of subchronic administration of antiseizure drugs in spontaneously seizing rats.

Accurate detection of spontaneous seizures using a generalized linear model with external validation.

Reactivity and increased proliferation of NG2 cells following central nervous system infection with Theiler's murine encephalomyelitis virus.

Identification of clinically relevant biomarkers of epileptogenesis - a strategic roadmap.

Response: Usefulness of the post-kainate spontaneous recurrent seizure model for screening for antiseizure and for neuroprotective effects.

Development of an antiseizure drug screening platform for Dravet syndrome at the NINDS contract site for the Epilepsy Therapy Screening Program.

Antiepileptogenesis and disease modification: Progress, challenges, and the path forward-Report of the Preclinical Working Group of the 2018 NINDS-sponsored antiepileptogenesis and disease modification workshop.

Development of an antiepileptogenesis drug screening platform: Effects of everolimus and phenobarbital.

Screening of prototype antiseizure and anti-inflammatory compounds in the Theiler's murine encephalomyelitis virus model of epilepsy.

Spontaneous recurrent seizures in an intra-amygdala kainate microinjection model of temporal lobe epilepsy are differentially sensitive to antiseizure drugs.

Inflammation Unleashed in Viral-Induced Epileptogenesis.