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Primitive CML cell expansion relies on abnormal levels of BMPs provided by the niche and on BMPRIb overexpression.
Blood Nov, 2013 | Pubmed ID: 24100446
Disequilibrium of BMP2 levels in the breast stem cell niche launches epithelial transformation by overamplifying BMPR1B cell response.
Stem cell reports Feb, 2015 | Pubmed ID: 25601208
Local mitochondrial-endolysosomal microfusion cleaves voltage-dependent anion channel 1 to promote survival in hypoxia.
Molecular and cellular biology May, 2015 | Pubmed ID: 25691661
Immature CML cells implement a BMP autocrine loop to escape TKI treatment.
Blood Dec, 2017 | Pubmed ID: 29138221
The BMP pathway: A unique tool to decode the origin and progression of leukemia.
Experimental hematology May, 2018 | Pubmed ID: 29477370
A new signaling cascade linking BMP4, BMPR1A, ΔNp73 and NANOG impacts on stem-like human cell properties and patient outcome.
Cell death & disease Sep, 2018 | Pubmed ID: 30262802
The quiescent fraction of chronic myeloid leukemic stem cells depends on BMPR1B, Stat3 and BMP4-niche signals to persist in patients in remission.
Haematologica Jan, 2021 | Pubmed ID: 32001529
A minimal standardized human bone marrow microphysiological system to assess resident cell behavior during normal and pathological processes.
Biomaterials science Jan, 2022 | Pubmed ID: 34904143
Altered BMP2/4 Signaling in Stem Cells and Their Niche: Different Cancers but Similar Mechanisms, the Example of Myeloid Leukemia and Breast Cancer.
Frontiers in cell and developmental biology , 2021 | Pubmed ID: 35047500
Erratum for Brahimi-Horn et al., "Local Mitochondrial-Endolysosomal Microfusion Cleaves the Voltage-Dependent Anion Channel 1 To Promote Survival in Hypoxia".
Molecular and cellular biology Jan, 2022 | Pubmed ID: 35049340
Centre de Recherche en Cancérologie de Lyon
Université de Lyon
Kawtar Arizkane1,2,3,
Kevin Geistlich1,2,3,4,
Laurine Moindrot1,2,3,
Emma Risson1,2,3,
Sandrine Jeanpierre1,2,3,4,
Léa Barral1,2,3,
Anaëlle Bobard1,2,3,
Giulio Menegazzi5,
Thibault Voeltzel1,2,3,
Véronique Maguer-Satta1,2,3,
Sylvain Lefort1,2,3
1, Centre de Recherche en Cancérologie de Lyon,
2, Centre de Recherche en Cancérologie de Lyon,
3, Université de Lyon,
4, Centre Léon Bérard,
5Department of Experimental and Clinical Biomedical Sciences Mario Serio, Università degli Studi di Firenze
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