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Michael J. Galko

Department of Biochemistry and Molecular Biology,
Department of Genetics,
Neuroscience Graduate Program,
Graduate School of Biomedical Sciences,
Genetics and Epigenetics Graduate Program,
Neuroscience Graduate Program, Graduate School of Biomedical Sciences,
Genetics and Epigenetics Graduate Program, Graduate School of Biomedical Sciences

The University of Texas MD Anderson Cancer Center

BIOGRAPHY

Dr. Galko obtained his Ph.D. with Dr. Marc Tessier-Lavigne at the University of California San Francisco and performed his postdoctoral studies with Dr. Mark Krasnow, at the Stanford University School of Medicine. As a postdoctoral scholar he developed a novel genetically tractable system to study epidermal wound healing using fruit fly (Drosophila melanogaster) larvae. In 2005 he started his own laboratory at the University of Texas MD Anderson Cancer Center, where he is now a full professor. His laboratory uses the fruit fly to dissect how organisms respond to tissue damage. About half of the lab studies epithelial wound healing and half studies tissue damage-induced nociceptive sensitization. His lab has made numerous original contributions to both fields.

PUBLICATIONS

Cellular and genetic analysis of wound healing in Drosophila larvae.

PLoS biology Aug, 2004 | Pubmed ID: 15269788

Live imaging of wound inflammation in Drosophila embryos reveals key roles for small GTPases during in vivo cell migration.

The Journal of cell biology Feb, 2005 | Pubmed ID: 15699212

Circulating blood cells function as a surveillance system for damaged tissue in Drosophila larvae.

Proceedings of the National Academy of Sciences of the United States of America Jul, 2008 | Pubmed ID: 18632567

Active cop, passive cop: developmental stage-specific modes of wound-induced blood cell recruitment in Drosophila.

Fly Nov-Dec, 2008 | Pubmed ID: 19077535

Cytokine signaling mediates UV-induced nociceptive sensitization in Drosophila larvae.

Current biology : CB May, 2009 | Pubmed ID: 19375319

A blood-borne PDGF/VEGF-like ligand initiates wound-induced epidermal cell migration in Drosophila larvae.

Current biology : CB Sep, 2009 | Pubmed ID: 19646875

Two sides of the same coin no longer: genetic separation of nociceptive sensitization responses.

Communicative & integrative biology Nov, 2009 | Pubmed ID: 20195458

A targeted UAS-RNAi screen in Drosophila larvae identifies wound closure genes regulating distinct cellular processes.

Genetics Nov, 2010 | Pubmed ID: 20813879

Hedgehog signaling regulates nociceptive sensitization.

Current biology : CB Sep, 2011 | Pubmed ID: 21906949

Pokes, sunburn, and hot sauce: Drosophila as an emerging model for the biology of nociception.

Developmental dynamics : an official publication of the American Association of Anatomists Jan, 2012 | Pubmed ID: 21932321

Transcriptional regulation of Profilin during wound closure in Drosophila larvae.

Journal of cell science Dec, 2012 | Pubmed ID: 22976306

Autophagy drives epidermal deterioration in a Drosophila model of tissue aging.

Aging Apr, 2013 | Pubmed ID: 23599123

Using Drosophila larvae to study epidermal wound closure and inflammation.

Methods in molecular biology (Clifton, N.J.) , 2013 | Pubmed ID: 24029952

Macrophages gain a partner at the table: epidermal cells digest peripheral dendritic debris in Drosophila.

Neuron Feb, 2014 | Pubmed ID: 24507184

Will the wound-healing field earn its wings?

Experimental dermatology Nov, 2014 | Pubmed ID: 25040854

Rapid clearance of epigenetic protein reporters from wound edge cells in Drosophila larvae does not depend on the JNK or PDGFR/VEGFR signaling pathways.

Regeneration (Oxford, England) Apr, 2014 | Pubmed ID: 25114797

Integrin Adhesions Suppress Syncytium Formation in the Drosophila Larval Epidermis.

Current biology : CB Aug, 2015 | Pubmed ID: 26255846

Wound Signaling: Monkeywrenching Macrophage Migration with Microscopes, Movies, and Math.

Current biology : CB Aug, 2016 | Pubmed ID: 27505244

The TRP Channels Pkd2, NompC, and Trpm Act in Cold-Sensing Neurons to Mediate Unique Aversive Behaviors to Noxious Cold in Drosophila.

Current biology : CB Dec, 2016 | Pubmed ID: 27818173

Yorkie regulates epidermal wound healing in Drosophila larvae independently of cell proliferation and apoptosis.

Developmental biology 07, 2017 | Pubmed ID: 28514643

Insulin receptor regulates the persistence of injury-induced nociceptive sensitization.

Disease models & mechanisms 05, 2018 | Pubmed ID: 29752280

Growth Factor Signaling Regulates Mechanical Nociception in Flies and Vertebrates.

The Journal of neuroscience : the official journal of the Society for Neuroscience 07, 2019 | Pubmed ID: 31138657

Casein kinase 1α decreases β-catenin levels at adherens junctions to facilitate wound closure in larvae.

Development (Cambridge, England) 10, 2019 | Pubmed ID: 31511254

INSTITUTIONS

The University of Texas MD Anderson Cancer Center

University of Texas Graduate School of Biomedical Sciences

UT MD Anderson Cancer Center

Graduate School of Biomedical Sciences at Houston

JOVE ARTICLES

Local and Global Methods of Assessing Thermal Nociception in Drosophila Larvae

Abanti Chattopadhyay^*,1,

A'Tondra V. Gilstrap^*,1,2,

Michael J. Galko^1,3,4

¹Department of Biochemistry and Molecular Biology, The University of Texas MD Anderson Cancer Center,

²Scholars Academy/MARC Scholar, University of Houston-Downtown,

³Genes and Development Graduate Program, University of Texas Graduate School of Biomedical Sciences,

⁴Neuroscience Graduate Program, University of Texas Graduate School of Biomedical Sciences

JoVE Journal

Novel Assay for Cold Nociception in Drosophila Larvae

Heather N. Turner^1,2,5,

Christian Landry³,

Michael J. Galko^1,2,4

¹Department of Genetics, UT MD Anderson Cancer Center,

²Neuroscience Program, Graduate School of Biomedical Sciences at Houston,

³, ProDev Engineering,

⁴Genes and Development Program, Graduate School of Biomedical Sciences at Houston,

⁵Section of Neurobiology, University of Southern California

Neuroscience

An Improved Assay and Tools for Measuring Mechanical Nociception in Drosophila Larvae

Roger Lopez-Bellido¹,

Michael J. Galko^1,2,3

¹Department of Genetics, The University of Texas MD Anderson Cancer Center,

²Neuroscience Graduate Program, Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center,

³Genetics and Epigenetics Graduate Program, Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center

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