Gabriel C. Lander

Exploring icosahedral virus structures with VIPER.

The structure of an infectious P22 virion shows the signal for headful DNA packaging.

Automated cryoEM data acquisition and analysis of 284742 particles of GroEL.

Polyvalent display of heme on hepatitis B virus capsid protein through coordination to hexahistidine tags.

A test-bed for optimizing high-resolution single particle reconstructions.

Assembly architecture and DNA binding of the bacteriophage P22 terminase small subunit.

Bacteriophage lambda stabilization by auxiliary protein gpD: timing, location, and mechanism of attachment determined by cryo-EM.

Appion: an integrated, database-driven pipeline to facilitate EM image processing.

Ab initio maximum likelihood reconstruction from cryo electron microscopy images of an infectious virion of the tailed bacteriophage P22 and maximum likelihood versions of Fourier Shell Correlation appropriate for measuring resolution of spherical or cylindrical objects.

Drosophila A virus is an unusual RNA virus with a T=3 icosahedral core and permuted RNA-dependent RNA polymerase.

The P22 tail machine at subnanometer resolution reveals the architecture of an infection conduit.

A toolbox for ab initio 3-D reconstructions in single-particle electron microscopy.

An automated procedure for detecting protein folds from sub-nanometer resolution electron density.

Subunits fold at position-dependent rates during maturation of a eukaryotic RNA virus.

Peering down the barrel of a bacteriophage portal: the genome packaging and release valve in p22.

Capsomer dynamics and stabilization in the T = 12 marine bacteriophage SIO-2 and its procapsid studied by CryoEM.

DNA bending-induced phase transition of encapsidated genome in phage λ.

Solid-to-fluid-like DNA transition in viruses facilitates infection.

The Pex1/Pex6 complex is a heterohexameric AAA+ motor with alternating and highly coordinated subunits.

Structural organization of the dynein-dynactin complex bound to microtubules.

Multivalent Microtubule Recognition by Tubulin Tyrosine Ligase-like Family Glutamylases.

Architecture of the Complex Formed by Large and Small Terminase Subunits from Bacteriophage P22.

Ubp6 deubiquitinase controls conformational dynamics and substrate degradation of the 26S proteasome.

Site-specific labeling of proteins for electron microscopy.

Thermodynamic Interrogation of the Assembly of a Viral Genome Packaging Motor Complex.

Atomic structure of the 26S proteasome lid reveals the mechanism of deubiquitinase inhibition.

Cryo-electron microscopy structure of the TRPV2 ion channel.

A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase.

Isolation of yeast complex IV in native lipid nanodiscs.

What's the Key to Unlocking the Proteasome's Gate?

Structure Reveals Mechanisms of Viral Suppressors that Intercept a CRISPR RNA-Guided Surveillance Complex.

Cas1 and the Csy complex are opposing regulators of Cas2/3 nuclease activity.

The endoplasmic reticulum HSP40 co-chaperone ERdj3/DNAJB11 assembles and functions as a tetramer.

Achieving better-than-3-Å resolution by single-particle cryo-EM at 200 keV.

Cryo-electron microscopy structure of the lysosomal calcium-permeable channel TRPML3.

Structure of the mitochondrial inner membrane AAA+ protease YME1 gives insight into substrate processing.

Structure of the cold- and menthol-sensing ion channel TRPM8.

The peroxisomal AAA-ATPase Pex1/Pex6 unfolds substrates by processive threading.

Cryo-electron tomography reveals that dynactin recruits a team of dyneins for processive motility.

Author Correction: Cryo-electron tomography reveals that dynactin recruits a team of dyneins for processive motility.

Exploring applications of crowdsourcing to cryo-EM.

Cryo-EM structure of a mitochondrial calcium uniporter.

Insights into autophagosome biogenesis from structural and biochemical analyses of the ATG2A-WIPI4 complex.

Substrate-engaged 26 proteasome structures reveal mechanisms for ATP-hydrolysis-driven translocation.

Conformational ensemble of the human TRPV3 ion channel.

A Multi-model Approach to Assessing Local and Global Cryo-EM Map Quality.

The rod-shaped ATG2A-WIPI4 complex tethers membranes in vitro.

High-resolution structure determination of sub-100 kDa complexes using conventional cryo-EM.

Structure Reveals a Mechanism of CRISPR-RNA-Guided Nuclease Recruitment and Anti-CRISPR Viral Mimicry.

Setting the dynein motor in motion: New insights from electron tomography.

An allosteric network in spastin couples multiple activities required for microtubule severing.

Unique Structural Features of the Mitochondrial AAA+ Protease AFG3L2 Reveal the Molecular Basis for Activity in Health and Disease.

Visualizing structural transitions of ligand-dependent gating of the TRPM2 channel.

Current outcomes when optimizing 'standard' sample preparation for single-particle cryo-EM.

The molecular principles governing the activity and functional diversity of AAA+ proteins.

Specific lid-base contacts in the 26s proteasome control the conformational switching required for substrate degradation.

Dynamics at the serine loop underlie differential affinity of cryptochromes for CLOCK:BMAL1 to control circadian timing.

Author Correction: An allosteric network in spastin couples multiple activities required for microtubule severing.

AcrIF9 tethers non-sequence specific dsDNA to the CRISPR RNA-guided surveillance complex.

Structural basis for distinct operational modes and protease activation in AAA+ protease Lon.

How low can we go? Structure determination of small biological complexes using single-particle cryo-EM.

Sub-2 Angstrom resolution structure determination using single-particle cryo-EM at 200 keV.

Present and Emerging Methodologies in Cryo-EM Single-Particle Analysis.

A guided approach for subtomogram averaging of challenging macromolecular assemblies.

Structures of the human LONP1 protease reveal regulatory steps involved in protease activation.

Structural basis for piRNA targeting.

Conquer by cryo-EM without physically dividing.

A case for glycerol as an acceptable additive for single-particle cryoEM samples.

Cryo-EM structure of hexameric yeast Lon protease (PIM1) highlights the importance of conserved structural elements.

Allosteric differences dictate GroEL complementation of E. coli.

The YΦ motif defines the structure-activity relationships of human 20S proteasome activators.

Coupling of distant ATPase domains in the circadian clock protein KaiC.

Structural basis for shape-selective recognition and aminoacylation of a D-armless human mitochondrial tRNA.

Structure of the hepatitis C virus E1E2 glycoprotein complex.

Molecular glue CELMoD compounds are regulators of cereblon conformation.

Succinylation of a KEAP1 sensor lysine promotes NRF2 activation.

DELE1 oligomerization promotes integrated stress response activation.

Structural basis for a degenerate tRNA identity code and the evolution of bimodal specificity in human mitochondrial tRNA recognition.

Succinylation of a KEAP1 sensor lysine promotes NRF2 activation.