Pieter S. Hiemstra

World Congress on Lung Health and 10th ERS Annual Congress 30 August-3 September 2000, Florence, Italy.

Expression of beta-defensin 1 and 2 mRNA by human monocytes, macrophages and dendritic cells.

An angiogenic role for the human peptide antibiotic LL-37/hCAP-18.

Neutrophil defensins enhance lung epithelial wound closure and mucin gene expression in vitro.

Are rhinovirus-induced airway responses in asthma aggravated by chronic allergen exposure?

Rhinovirus increases human beta-defensin-2 and -3 mRNA expression in cultured bronchial epithelial cells.

Series introduction: Innate host defense of the respiratory epithelium.

The antimicrobial peptide LL-37 activates innate immunity at the airway epithelial surface by transactivation of the epidermal growth factor receptor.

Gene expression profile and histopathology of experimental bronchopulmonary dysplasia induced by prolonged oxidative stress.

Bacterial products increase expression of the human cathelicidin hCAP-18/LL-37 in cultured human sinus epithelial cells.

TGF-beta differentially regulates TH2 cytokine-induced eotaxin and eotaxin-3 release by human airway smooth muscle cells.

Interactions between neutrophil-derived antimicrobial peptides and airway epithelial cells.

Transcriptional response of bronchial epithelial cells to Pseudomonas aeruginosa: identification of early mediators of host defense.

Eotaxin-2 and eotaxin-3 expression is associated with persistent eosinophilic bronchial inflammation in patients with asthma after allergen challenge.

The human cathelicidin LL-37: a multifunctional peptide involved in infection and inflammation in the lung.

Host defense effector molecules in mucosal secretions.

Bronchial CD8 cell infiltrate and lung function decline in asthma.

Cytokine-dependent proliferation of human CD34+ progenitor cells in the absence of serum is suppressed by their progeny's production of serine proteinases.

Development of novel LL-37 derived antimicrobial peptides with LPS and LTA neutralizing and antimicrobial activities for therapeutic application.

Effects of cigarette smoke condensate on proliferation and wound closure of bronchial epithelial cells in vitro: role of glutathione.

Expression of epidermal growth factors and their receptors in the bronchial epithelium of subjects with chronic obstructive pulmonary disease.

A molecular signature of epithelial host defense: comparative gene expression analysis of cultured bronchial epithelial cells and keratinocytes.

Human cathelicidin LL-37 is a chemoattractant for eosinophils and neutrophils that acts via formyl-peptide receptors.

Epithelial differentiation is a determinant in the production of eotaxin-2 and -3 by bronchial epithelial cells in response to IL-4 and IL-13.

The antimicrobial peptide LL-37 enhances IL-8 release by human airway smooth muscle cells.

The SERPINE2 gene and chronic obstructive pulmonary disease.

Exploring host-pathogen interactions at the epithelial surface: application of transcriptomics in lung biology.

Adenovirus-specific CD4+ T cell clones recognizing endogenous antigen inhibit viral replication in vitro through cognate interaction.

Small airways dysfunction and neutrophilic inflammation in bronchial biopsies and BAL in COPD.

Demonstration of bacterial cells and glycocalyx in biofilms on human tonsils.

Bronchial inflammation and airway responses to deep inspiration in asthma and chronic obstructive pulmonary disease.

Inhaled nitric oxide attenuates pulmonary inflammation and fibrin deposition and prolongs survival in neonatal hyperoxic lung injury.

Human neutrophil peptide-1 inhibits both the classical and the lectin pathway of complement activation.

Reduction in sputum neutrophil and eosinophil numbers by the PDE4 inhibitor roflumilast in patients with COPD.

The role of epithelial beta-defensins and cathelicidins in host defense of the lung.

An antimicrobial peptide modulates epithelial responses to bacterial products.

Expression of smooth muscle and extracellular matrix proteins in relation to airway function in asthma.

Comparison of exhaled breath condensate pH using two commercially available devices in healthy controls, asthma and COPD patients.

Effect of fluticasone with and without salmeterol on pulmonary outcomes in chronic obstructive pulmonary disease: a randomized trial.

Association of MMP-2 polymorphisms with severe and very severe COPD: a case control study of MMPs-1, 9 and 12 in a European population.

Expression patterns of protein C inhibitor in mouse development.

Recent advances in alveolar biology: evolution and function of alveolar proteins.

Multidrug resistance-associated protein-1 (MRP1) genetic variants, MRP1 protein levels and severity of COPD.

LL-37 directs macrophage differentiation toward macrophages with a proinflammatory signature.

Severe congenital neutropenia in a multigenerational family with a novel neutrophil elastase (ELANE) mutation.

Pro-inflammatory mechanisms of muscarinic receptor stimulation in airway smooth muscle.

The role of IREB2 and transforming growth factor beta-1 genetic variants in COPD: a replication case-control study.

Smoking status and anti-inflammatory macrophages in bronchoalveolar lavage and induced sputum in COPD.

IL-4 and IL-13 exposure during mucociliary differentiation of bronchial epithelial cells increases antimicrobial activity and expression of antimicrobial peptides.

PRAME-specific Allo-HLA-restricted T cells with potent antitumor reactivity useful for therapeutic T-cell receptor gene transfer.

Hepatocyte-specific IKKβ expression aggravates atherosclerosis development in APOE*3-Leiden mice.

A quantitative method for detection of spliced X-box binding protein-1 (XBP1) mRNA as a measure of endoplasmic reticulum (ER) stress.

α1-antitrypsin production by proinflammatory and antiinflammatory macrophages and dendritic cells.

Difference in symptom severity between early and late grass pollen season in patients with seasonal allergic rhinitis.

Toll-like receptor (TLR2 and TLR4) polymorphisms and chronic obstructive pulmonary disease.

Profiling the proteome of exhaled breath condensate in healthy smokers and COPD patients by LC-MS/MS.

Resveratrol protects against atherosclerosis, but does not add to the antiatherogenic effect of atorvastatin, in APOE*3-Leiden.CETP mice.

Systemic inflammation and lung function impairment in morbidly obese subjects with the metabolic syndrome.

CD8(+) T cells characterize early smoking-related airway pathology in patients with asthma.

Inhaled steroids modulate extracellular matrix composition in bronchial biopsies of COPD patients: a randomized, controlled trial.

Development and validation of a 5-day-ahead hay fever forecast for patients with grass-pollen-induced allergic rhinitis.

Airway gene expression in COPD is dynamic with inhaled corticosteroid treatment and reflects biological pathways associated with disease activity.

Development of a nose cream containing the synthetic antimicrobial peptide P60.4Ac for eradication of methicillin-resistant Staphylococcus aureus carriage.

Increase in net activity of serine proteinases but not gelatinases after local endotoxin exposure in the peripheral airways of healthy subjects.

Increased ERK signalling promotes inflammatory signalling in primary airway epithelial cells expressing Z α1-antitrypsin.

The effect of PPE-induced emphysema and chronic LPS-induced pulmonary inflammation on atherosclerosis development in APOE*3-LEIDEN mice.

Recent progress in peptide vaccination in cancer with a focus on non-small-cell lung cancer.

pH in exhaled breath condensate and nasal lavage as a biomarker of air pollution-related inflammation in street traffic-controllers and office-workers.

Steroid resistance in COPD? Overlap and differential anti-inflammatory effects in smokers and ex-smokers.

Susceptibility to chronic mucus hypersecretion, a genome wide association study.

LL-37-derived peptides eradicate multidrug-resistant Staphylococcus aureus from thermally wounded human skin equivalents.

Efficient and sensitive identification and quantification of airborne pollen using next-generation DNA sequencing.

Genome-wide association analysis identifies six new loci associated with forced vital capacity.

Dissecting the genetics of chronic mucus hypersecretion in smokers with and without COPD.

Club cells, CC10 and self-control at the epithelial surface.

Function of monocytes and monocyte-derived macrophages in α1-antitrypsin deficiency.

Brown adipose tissue takes up plasma triglycerides mostly after lipolysis.

Reproducibility of exhaled nitric oxide measurements in overweight and obese adults.

Muscarinic M3 receptors on structural cells regulate cigarette smoke-induced neutrophilic airway inflammation in mice.

Genome-Wide Association Study Identification of Novel Loci Associated with Airway Responsiveness in Chronic Obstructive Pulmonary Disease.

Asthma-COPD overlap. Clinical relevance of genomic signatures of type 2 inflammation in chronic obstructive pulmonary disease.

The innate immune function of airway epithelial cells in inflammatory lung disease.

Basal cells contribute to innate immunity of the airway epithelium through production of the antimicrobial protein RNase 7.

Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development.

Vitamin D, vitamin D binding protein, and longitudinal outcomes in COPD.

Effect of bariatric surgery on asthma control, lung function and bronchial and systemic inflammation in morbidly obese subjects with asthma.

Tiotropium attenuates IL-13-induced goblet cell metaplasia of human airway epithelial cells.

Local and systemic XAGE-1b-specific immunity in patients with lung adenocarcinoma.

Prevention of exacerbations in patients with COPD and vitamin D deficiency through vitamin D supplementation (PRECOVID): a study protocol.

Therapeutic potential of soluble guanylate cyclase modulators in neonatal chronic lung disease.

Antimicrobial Peptides and Innate Lung Defenses: Role in Infectious and Noninfectious Lung Diseases and Therapeutic Applications.

Nasal Levels of Antimicrobial Peptides in Allergic Asthma Patients and Healthy Controls: Differences and Effect of a Short 1,25(OH)2 Vitamin D3 Treatment.

Parallel activities and interactions between antimicrobial peptides and complement in host defense at the airway epithelial surface.

The positive prognostic effect of stromal CD8+ tumor-infiltrating T cells is restrained by the expression of HLA-E in non-small cell lung carcinoma.

Prediction of Long-Term Benefits of Inhaled Steroids by Phenotypic Markers in Moderate-to-Severe COPD: A Randomized Controlled Trial.

Regulation of YKL-40 expression by corticosteroids: effect on pro-inflammatory macrophages in vitro and its modulation in COPD in vivo.

TNF-α and IL-1β-activated human mesenchymal stromal cells increase airway epithelial wound healing in vitro via activation of the epidermal growth factor receptor.

MicroRNA-223 controls the expression of histone deacetylase 2: a novel axis in COPD.

IL-13 and the Airway Epithelium. It Is All in the Genes.

Microbes and asthma: Opportunities for intervention.

Murine models of cardiovascular comorbidity in chronic obstructive pulmonary disease.

Neutrophil-derived alpha defensins control inflammation by inhibiting macrophage mRNA translation.

Regeneration of the lung: Lung stem cells and the development of lung mimicking devices.

Antimicrobial Peptide P60.4Ac-Containing Creams and Gel for Eradication of Methicillin-Resistant Staphylococcus aureus from Cultured Skin and Airway Epithelial Surfaces.

Cellular response of mucociliary differentiated primary bronchial epithelial cells to diesel exhaust.

Lung function decline in asthma patients with elevated bronchial CD8, CD4 and CD3 cells.

Azithromycin differentially affects the IL-13-induced expression profile in human bronchial epithelial cells.

Childhood allergies and asthma: New insights on environmental exposures and local immunity at the lung barrier.

The Dutch National Program for Respiratory Research.

Airway hyperresponsiveness in chronic obstructive pulmonary disease: A marker of asthma-chronic obstructive pulmonary disease overlap syndrome?

ADAM17 and EGFR regulate IL-6 receptor and amphiregulin mRNA expression and release in cigarette smoke-exposed primary bronchial epithelial cells from patients with chronic obstructive pulmonary disease (COPD).

Basic science of electronic cigarettes: assessment in cell culture and in vivo models.

Functional characterisation of bone marrow-derived mesenchymal stromal cells from COPD patients.

Xenobiotic metabolism in differentiated human bronchial epithelial cells.

Cigarette Smoke Modulates Repair and Innate Immunity following Injury to Airway Epithelial Cells.

Airway inflammation in COPD after long-term withdrawal of inhaled corticosteroids.

Standard radiotherapy but not chemotherapy impairs systemic immunity in non-small cell lung cancer.

Diesel exhaust alters the response of cultured primary bronchial epithelial cells from patients with chronic obstructive pulmonary disease (COPD) to non-typeable Haemophilus influenzae.

Antibacterial Defense of Human Airway Epithelial Cells from Chronic Obstructive Pulmonary Disease Patients Induced by Acute Exposure to Nontypeable Haemophilus influenzae: Modulation by Cigarette Smoke.

Proinflammatory Cytokines Impair Vitamin D-Induced Host Defense in Cultured Airway Epithelial Cells.

Antimicrobial peptide levels are linked to airway inflammation, bacterial colonisation and exacerbations in chronic obstructive pulmonary disease.

Defining asthma-COPD overlap syndrome: a population-based study.

Use of airway epithelial cell culture to unravel the pathogenesis and study treatment in obstructive airway diseases.

Airway inflammation in COPD after long-term withdrawal of inhaled corticosteroids.

The effect of tiotropium in combination with olodaterol on house dust mite-induced allergic airway disease.

Cigarette smoke differentially affects IL-13-induced gene expression in human airway epithelial cells.

Bone Morphogenetic Protein 9 Protects against Neonatal Hyperoxia-Induced Impairment of Alveolarization and Pulmonary Inflammation.

The Effects of Selective Hematopoietic Expression of Human IL-37 on Systemic Inflammation and Atherosclerosis in LDLr-Deficient Mice.

Pre-surgical Pulmonary Rehabilitation in Asthma Patients Undergoing Bariatric Surgery.

Acute and chronic effects of treatment with mesenchymal stromal cells on LPS-induced pulmonary inflammation, emphysema and atherosclerosis development.

Airway Epithelial Barrier Dysfunction in Chronic Obstructive Pulmonary Disease: Role of Cigarette Smoke Exposure.

microRNA profiling in lung tissue and bronchoalveolar lavage of cigarette smoke-exposed mice and in COPD patients: a translational approach.

Human lung epithelial cell cultures for analysis of inhaled toxicants: Lessons learned and future directions.

Reprogramming of cellular metabolism: driver for airway remodelling in COPD?

Pulmonary function, exhaled nitric oxide and symptoms in asthma patients with obesity: a cross-sectional study.

Associations of Serum 25(OH)D Concentrations with Lung Function, Airway Inflammation and Common Cold in the General Population.

Therapeutic Application of an Extract of Ameliorates the Development of Allergic Airway Disease.

Effect of diesel exhaust generated by a city bus engine on stress responses and innate immunity in primary bronchial epithelial cell cultures.

Farm dust reduces viral load in human bronchial epithelial cells by increasing barrier function and antiviral responses.

Assembly 3: Basic and Translational Sciences.

Effects of E-Cigarette Use on Human Lung Tissue. On Harm Reduction and Causing Harm.

Aberrant epithelial differentiation by cigarette smoke dysregulates respiratory host defence.

Mesenchymal stromal cells: a novel therapy for the treatment of chronic obstructive pulmonary disease?

Response to Comment on "Therapeutic Application of an Extract of Ameliorates the Development of Allergic Airway Disease".

Airway Epithelial Cell Function and Respiratory Host Defense in Chronic Obstructive Pulmonary Disease.

Predictive value of eosinophils and neutrophils on clinical effects of ICS in COPD.

Basic and translational research in the .

A novel method for expansion and differentiation of mouse tracheal epithelial cells in culture.

Aerobic Exercise Protects from Pseudomonas aeruginosa-Induced Pneumonia in Elderly Mice.

Immunomodulatory innate defence regulator (IDR) peptide alleviates airway inflammation and hyper-responsiveness.

Stem cell-based Lung-on-Chips: The best of both worlds?

Contribution of Host Defence Proteins and Peptides to Host-Microbiota Interactions in Chronic Inflammatory Lung Diseases.

Retinoic acid signaling balances adult distal lung epithelial progenitor cell growth and differentiation.

Electronic cigarettes: a task force report from the European Respiratory Society.

How to write a response to the reviewers of your manuscript.

Dynamic differences in dietary polyunsaturated fatty acid metabolism in sputum of COPD patients and controls.

Effect of long-term corticosteroid treatment on microRNA and gene-expression profiles in COPD.

TGF-β activation impairs fibroblast ability to support adult lung epithelial progenitor cell organoid formation.

TGF-β1 Impairs Vitamin D-Induced and Constitutive Airway Epithelial Host Defense Mechanisms.

Antimicrobial Host Defence Peptides: Immunomodulatory Functions and Translational Prospects.

Macrophage function in chronic obstructive pulmonary disease: The many faces of notch signalling.

From the pathophysiology of the human lung alveolus to epigenetic editing: Congress 2018 highlights from ERS Assembly 3 "Basic and Translational Science.".

Extract of Helicobacter pylori Ameliorates Parameters of Airway Inflammation and Goblet Cell Hyperplasia following Repeated Allergen Exposure.

Blood eosinophil count and airway epithelial transcriptome relationships in COPD versus asthma.

Airway and alveolar epithelial cells in culture.

Sputum microbiota and inflammation at stable state and during exacerbations in a cohort of chronic obstructive pulmonary disease (COPD) patients.

Perioperative proADM-change is associated with the development of acute respiratory distress syndrome in critically ill cardiac surgery patients: a prospective cohort study.

Translation of findings to patients with asthma: a timely and compelling challenge.

The respiratory virome and exacerbations in patients with chronic obstructive pulmonary disease.

Osteopontin Expression in Small Airway Epithelium in Copd is Dependent on Differentiation and Confined to Subsets of Cells.

Mitochondria: at the crossroads of regulating lung epithelial cell function in chronic obstructive pulmonary disease.

Innate Immunity of the Lung.

Author Correction: Osteopontin Expression in Small Airway Epithelium in Copd is Dependent on Differentiation and Confined to Subsets of Cells.

Tumor mutational load, CD8 T cells, expression of PD-L1 and HLA class I to guide immunotherapy decisions in NSCLC patients.

ERS International Congress, Madrid, 2019: highlights from the Basic and Translational Science Assembly.

In vitro modelling of alveolar repair at the air-liquid interface using alveolar epithelial cells derived from human induced pluripotent stem cells.

Modulation of Airway Epithelial Innate Immunity and Wound Repair by M(GM-CSF) and M(M-CSF) Macrophages.

Short-term and long-term effect of a high-intensity pulmonary rehabilitation programme in obese patients with asthma: a randomised controlled trial.

Adiposity is a confounding factor which largely explains the association of serum vitamin D concentrations with C-reactive protein, leptin and adiponectin.

Vitamin D Deficiency in Asthma and Chronic Obstructive Pulmonary Disease. A Chicken-or-Egg Story.

Host-microbe cross-talk in the lung microenvironment: implications for understanding and treating chronic lung disease.

Suramin Inhibits SARS-CoV-2 Infection in Cell Culture by Interfering with Early Steps of the Replication Cycle.

Wnt/β-catenin signaling is critical for regenerative potential of distal lung epithelial progenitor cells in homeostasis and emphysema.

Tiotropium and Fluticasone Inhibit Rhinovirus-Induced Mucin Production via Multiple Mechanisms in Differentiated Airway Epithelial Cells.

Impact of the Local Inflammatory Environment on Mucosal Vitamin D Metabolism and Signaling in Chronic Inflammatory Lung Diseases.

RAGE and TLR4 differentially regulate airway hyperresponsiveness: Implications for COPD.

An emerging class of air pollutants: Potential effects of microplastics to respiratory human health?

A new portable sampler to monitor pollen at street level in the environment of patients.

Air-Liquid Interface Models for Respiratory Toxicology Research: Consensus Workshop and Recommendations.

Bronchial gene expression signature associated with rate of subsequent FEV decline in individuals with and at risk of COPD.

Novel insights into surfactant protein C trafficking revealed through the study of a pathogenic mutant.

Gender specific airway gene expression in COPD sub-phenotypes supports a role of mitochondria and of different types of leukocytes.

Repairing damaged lungs using regenerative therapy.

Comparison of genome-wide gene expression profiling by RNA Sequencing microarray in bronchial biopsies of COPD patients before and after inhaled corticosteroid treatment: does it provide new insights?

The Course of AαVal541 as a Proteinase 3 Specific Neo-Epitope after Alpha-1-Antitrypsin Augmentation in Severe Deficient Patients.

Disease modeling following organoid-based expansion of airway epithelial cells.

Factors associated with physical activity among COPD patients with mild or moderate airflow obstruction.

Kallikrein-related peptidase 5 contributes to the remodeling and repair of bronchial epithelium.

Determinants of expression of SARS-CoV-2 entry-related genes in upper and lower airways.

Prolonged activation of nasal immune cell populations and development of tissue-resident SARS-CoV-2-specific CD8 T cell responses following COVID-19.

The lower airways microbiome and antimicrobial peptides in idiopathic pulmonary fibrosis differ from chronic obstructive pulmonary disease.

Lung epithelial cells interact with immune cells and bacteria to shape the microenvironment in tuberculosis.

Organoid-based expansion of patient-derived primary alveolar type 2 cells for establishment of alveolus epithelial Lung-Chip cultures.

Role of air pollutants in airway epithelial barrier dysfunction in asthma and COPD.

Performance of Five Metagenomic Classifiers for Virus Pathogen Detection Using Respiratory Samples from a Clinical Cohort.

Dysregulated mitochondrial metabolism upon cigarette smoke exposure in various human bronchial epithelial cell models.

High miR203a-3p and miR-375 expression in the airways of smokers with and without COPD.

Vitamin D supplementation in chronic obstructive pulmonary disease patients with low serum vitamin D: a randomized controlled trial.

Personalized Pollen Monitoring and Symptom Scores: A Feasibility Study in Grass Pollen Allergic Patients.

3D Lung-on-Chip Model Based on Biomimetically Microcurved Culture Membranes.

Host succinate inhibits influenza virus infection through succinylation and nuclear retention of the viral nucleoprotein.

Association of bronchial steroid inducible methylation quantitative trait loci with asthma and chronic obstructive pulmonary disease treatment response.

Keratin 8 is a scaffolding and regulatory protein of ERAD complexes.

Early transcriptional responses of bronchial epithelial cells to whole cigarette smoke mirror those of in-vivo exposed human bronchial mucosa.

The lower airways microbiota and antimicrobial peptides indicate dysbiosis in sarcoidosis.

Cigarette Smoke Impairs Airway Epithelial Wound Repair: Role of Modulation of Epithelial-Mesenchymal Transition Processes and Notch-1 Signaling.

SARS-CoV-2-specific CD4 and CD8 T cell responses can originate from cross-reactive CMV-specific T cells.

Combination of IL-17A/F and TNF-α uniquely alters the bronchial epithelial cell proteome to enhance proteins that augment neutrophil migration.

Th2 high and mast cell gene signatures are associated with corticosteroid sensitivity in COPD.

Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk.

Smoking increases expression of the SARS-CoV-2 spike protein-binding long ACE2 isoform in bronchial epithelium.