ex-vivo-calcium-imaging-for-drosophila-model-of-epilepsy

<em>Ex Vivo</em> Calcium Imaging for <em>Drosophila</em> Model of Epilepsy

Epilepsy is a neurological disorder characterized by recurrent seizures, partially correlated with genetic origin, affecting over 70 million individuals ...

The Second Clinical Medicine School of Guangzhou Medical University

With the advent of trio-based whole-exome sequencing, the identification of epilepsy candidate genes has become easier, resulting in a large number of potential genes that need to be validated in a whole-organism context. However, conducting animal experiments systematically and efficiently remains a challenge due to their laborious and time-consuming nature. This study aims to develop optimized strategies for validating epilepsy candidate genes using the  model.

Efficient strategies based on behavioral and electrophysiological methods for epilepsy-related gene screening in the  model.

It has been established that  encodes E3 ubiquitin ligase, which determines the specificity of substrate binding during protein ubiquitination and has been associated with various functions of the nervous system but not the reproductive system. Herein, we explored the role of  on fertility with a .

Yong-Miao Lin

The Second Clinical Medicine School of Guangzhou Medical University

Ex Vivo Calcium Imaging for Drosophila Model of Epilepsy