murine-orchiectomy-and-ovariectomy-to-reduce-sex-hormone-production

Murine Orchiectomy and Ovariectomy to Reduce Sex Hormone Production

Sex hormone signaling plays a critical role in multiple organ systems as well as in the progression of various diseases, including neurodegenerative ...

UT Southwestern Medical Center

Batten disease is characterized by cognitive and motor impairment, retinal degeneration, and seizures leading to premature death. Recent studies have shown efficacy for a gene therapy approach for CLN7 Batten disease. This gene therapy approach is promising to treat cognitive and motor impairment, but is not likely to delay vision loss. Additionally, the natural progression of retinal degeneration in CLN7 Batten disease patients is not well-known.

Long-term progression of retinal degeneration in a preclinical model of CLN7 Batten disease as a baseline for testing clinical therapeutics.

Biliary Atresia (BA), an obstructive cholangiopathy, is the most common cause of end-stage liver disease and liver transplantation in children. Timely differentiation of BA from other causes of neonatal jaundice remains a challenge, yet is critical to improving outcomes.

Yacine Issioui

Department of Ophthalmology

UT Southwestern Medical Center

Murine Orchiectomy and Ovariectomy to Reduce Sex Hormone Production

Yacine Issioui

.css-o250i3{font-size:18px;font-family:Open Sans,sans-serif;line-height:21.6px;}Department of Ophthalmology

UT Southwestern Medical Center

Murine Orchiectomy and Ovariectomy to Reduce Sex Hormone Production

Department of Ophthalmology