Richard Cubbon

The impact of insulin resistance on endothelial function, progenitor cells and repair.

Aspirin and mortality in patients with diabetes sustaining acute coronary syndrome.

Diabetes mellitus and mortality after acute coronary syndrome as a first or recurrent cardiovascular event.

Cardiac resynchronisation therapy for chronic heart failure and conduction delay.

Vascular insulin-like growth factor-I resistance and diet-induced obesity.

Effects of insulin resistance on endothelial progenitor cells and vascular repair.

Human exercise-induced circulating progenitor cell mobilization is nitric oxide-dependent and is blunted in South Asian men.

Insulin resistance impairs circulating angiogenic progenitor cell function and delays endothelial regeneration.

Orai1 and CRAC channel dependence of VEGF-activated Ca2+ entry and endothelial tube formation.

Changing characteristics and mode of death associated with chronic heart failure caused by left ventricular systolic dysfunction: a study across therapeutic eras.

The insulin-like growth factor-1 receptor is a negative regulator of nitric oxide bioavailability and insulin sensitivity in the endothelium.

Heavy and moderate interval exercise training alters low-flow-mediated constriction but does not increase circulating progenitor cells in healthy humans.

Insulin- and growth factor-resistance impairs vascular regeneration in diabetes mellitus.

Increasing circulating IGFBP1 levels improves insulin sensitivity, promotes nitric oxide production, lowers blood pressure, and protects against atherosclerosis.

Novel role of the IGF-1 receptor in endothelial function and repair: studies in endothelium-targeted IGF-1 receptor transgenic mice.

Moderate and heavy metabolic stress interval training improve arterial stiffness and heart rate dynamics in humans.

Gender-specific alterations in fibrin structure function in type 2 diabetes: associations with cardiometabolic and vascular markers.

Diabetes mellitus is associated with adverse prognosis in chronic heart failure of ischaemic and non-ischaemic aetiology.

Nox2 NADPH oxidase has a critical role in insulin resistance-related endothelial cell dysfunction.

Importance of insulin resistance to vascular repair and regeneration.

Cardiac resynchronization therapy in pacemaker-dependent patients with left ventricular dysfunction.

Endothelium-specific insulin resistance leads to accelerated atherosclerosis in areas with disturbed flow patterns: a role for reactive oxygen species.

Pacing-associated left ventricular dysfunction? Think reprogramming first!

Calcium, phosphate and calcium phosphate product are markers of outcome in patients with chronic heart failure.

Restoring Akt1 activity in outgrowth endothelial cells from South Asian men rescues vascular reparative potential.

Patients with long-term permanent pacemakers have a high prevalence of left ventricular dysfunction.

Haploinsufficiency of the insulin-like growth factor-1 receptor enhances endothelial repair and favorably modifies angiogenic progenitor cell phenotype.

Piezo1 integration of vascular architecture with physiological force.

Sudden cardiac death in patients with diabetes mellitus and chronic heart failure.

An evaluation of 20 year survival in patients with diabetes mellitus and acute myocardial infarction.

Ambulatory heart rate range predicts mode-specific mortality and hospitalisation in chronic heart failure.

Endothelial IGF-1 Receptor Signalling in Diabetes and Insulin Resistance.

Performance of 2014 NICE defibrillator implantation guidelines in heart failure risk stratification.

Cardio-oncology: Concepts and practice.

Effects of Vitamin D on Cardiac Function in Patients With Chronic HF: The VINDICATE Study.

Chronotropic Incompetence Does Not Limit Exercise Capacity in Chronic Heart Failure.

Diabetes mellitus is associated with adverse structural and functional cardiac remodelling in chronic heart failure with reduced ejection fraction.

Pericytes in diabetes-associated vascular disease.

Selective Enhancement of Insulin Sensitivity in the Endothelium In Vivo Reveals a Novel Proatherosclerotic Signaling Loop.

Insulin-Like Growth Factor Binding Protein 1 Could Improve Glucose Regulation and Insulin Sensitivity Through Its RGD Domain.

Role of glutamine and interlinked asparagine metabolism in vessel formation.

Association analyses based on false discovery rate implicate new loci for coronary artery disease.

Endothelial SHIP2 Suppresses Nox2 NADPH Oxidase-Dependent Vascular Oxidative Stress, Endothelial Dysfunction, and Systemic Insulin Resistance.

Piezo1 channels sense whole body physical activity to reset cardiovascular homeostasis and enhance performance.

Mortality Reduction Associated With β-Adrenoceptor Inhibition in Chronic Heart Failure Is Greater in Patients With Diabetes.

Insulinlike Growth Factor-Binding Protein-1 Improves Vascular Endothelial Repair in Male Mice in the Setting of Insulin Resistance.

Rate-Response Programming Tailored to the Force-Frequency Relationship Improves Exercise Tolerance in Chronic Heart Failure.

Socioeconomic deprivation and mode-specific outcomes in patients with chronic heart failure.

Homotypic endothelial nanotubes induced by wheat germ agglutinin and thrombin.

Endothelial Insulin Receptor Restoration Rescues Vascular Function in Male Insulin Receptor Haploinsufficient Mice.

Vitamin D deficiency is an independent predictor of mortality in patients with chronic heart failure.

Quiescent Endothelial Cells Upregulate Fatty Acid β-Oxidation for Vasculoprotection via Redox Homeostasis.

Role of glutamine synthetase in angiogenesis beyond glutamine synthesis.

Effects of obesity on insulin: insulin-like growth factor 1 hybrid receptor expression and Akt phosphorylation in conduit and resistance arteries.

Prevalence and Predictors of Sepsis Death in Patients With Chronic Heart Failure and Reduced Left Ventricular Ejection Fraction.

Ischemic Heart Disease Modifies the Association of Atrial Fibrillation With Mortality in Heart Failure With Reduced Ejection Fraction.

Prospective evaluation and long-term follow-up of patients referred to secondary care based upon natriuretic peptide levels in primary care.

Prognostic Significance of Incidental Nonsustained Ventricular Tachycardia Detected on Pacemaker Interrogation.

Predicting one-year mortality in heart failure using the 'Surprise Question': a prospective pilot study.

Contemporary treatment strategies for Type 2 diabetes-related macrovascular disease.

Optimising pacemaker therapy and medical therapy in pacemaker patients for heart failure: protocol for the OPT-PACE randomised controlled trial.

Divergent skeletal muscle mitochondrial phenotype between male and female patients with chronic heart failure.

Chronic heart failure with diabetes mellitus is characterized by a severe skeletal muscle pathology.

Inorganic Nitrate Promotes Glucose Uptake and Oxidative Catabolism in White Adipose Tissue Through the XOR-Catalyzed Nitric Oxide Pathway.

IGFBP-1 in Cardiometabolic Pathophysiology-Insights From Loss-of-Function and Gain-of-Function Studies in Male Mice.

Personalized Rate-Response Programming Improves Exercise Tolerance After 6 Months in People With Cardiac Implantable Electronic Devices and Heart Failure: A Phase II Study.

Infection-Related Hospitalization in Heart Failure With Reduced Ejection Fraction: A Prospective Observational Cohort Study.

Divergent effects of genetic and pharmacological inhibition of Nox2 NADPH oxidase on insulin resistance-related vascular damage.

Cardiovascular mortality and morbidity following radical radiotherapy for lung cancer: Is cardiovascular death under-reported?

Prioritizing symptom management in the treatment of chronic heart failure.

Unique Transcriptome Signature Distinguishes Patients With Heart Failure With Myopathy.

Effect of disease-modifying agents and their association with mortality in multi-morbid patients with heart failure with reduced ejection fraction.

Association of heart failure and its comorbidities with loss of life expectancy.

Response by Gierula et al to Letter Regarding Article, "Personalized Rate-Response Programming Improves Exercise Tolerance After 6 Months in People With Cardiac Implantable Electronic Devices and Heart Failure: A Phase II Study".

Dose-dependent oral glucocorticoid cardiovascular risks in people with immune-mediated inflammatory diseases: A population-based cohort study.

Advanced care planning during the COVID-19 pandemic: ceiling of care decisions and their implications for observational data.

Diabetes, gender and deterioration in estimated glomerular filtration rate in patients with chronic heart failure: Ten-year prospective cohort study.

Non-communicable disease, sociodemographic factors, and risk of death from infection: a UK Biobank observational cohort study.

Endothelial IGF-1 receptor mediates crosstalk with the gut wall to regulate microbiota in obesity.

Endothelial Insulin Receptors Promote VEGF-A Signaling via ERK1/2 and Sprouting Angiogenesis.

Elimination of fibrin γ-chain cross-linking by FXIIIa increases pulmonary embolism arising from murine inferior vena cava thrombi.

Impact of QRS duration on left ventricular remodelling and survival in patients with heart failure.

Suboptimal Dosing of β-Blockers in Chronic Heart Failure: A Missed Opportunity?

Novel Paracrine Action of Endothelium Enhances Glucose Uptake in Muscle and Fat.

Pericyte Insulin Receptors Modulate Retinal Vascular Remodeling and Endothelial Angiopoietin Signaling.

Empagliflozin Treatment Is Associated With Improvements in Cardiac Energetics and Function and Reductions in Myocardial Cellular Volume in Patients With Type 2 Diabetes.

Causes of Death in People With Cardiovascular Disease: A UK Biobank Cohort Study.

Personalised reprogramming to prevent progressive pacemaker-related left ventricular dysfunction: A phase II randomised, controlled clinical trial.

Hypoxia signalling in the regulation of innate immune training.

Coenzyme Q10 to manage chronic heart failure with a reduced ejection fraction: a systematic review and economic evaluation.

Endothelial Cell Fibrin Gel Angiogenesis Bead Assay.

Prospective Longitudinal Characterization of the Relationship between Diabetes and Cardiac Structural and Functional Changes.

Diabetes mellitus and the causes of hospitalisation in people with heart failure.

Coronary microvascular function and visceral adiposity in patients with normal body weight and type 2 diabetes.

Systemic Inflammation Is Associated With Future Risk of Fatal Infection: An Observational Cohort Study.

Cixutumumab reveals a critical role for IGF-1 in adipose and hepatic tissue remodelling during the development of diet-induced obesity.

Guideline-directed medical therapy is similarly effective in heart failure with mildly reduced ejection fraction.

Coexistent Diabetes Is Associated With the Presence of Adverse Phenotypic Features in Patients With Hypertrophic Cardiomyopathy.

Atrial fibrillation and risk of progressive heart failure in patients with preserved ejection fraction heart failure.

Reduction of heart failure guideline-directed medication during hospitalization: prevalence, risk factors, and outcomes.

Maternal Cardiac Changes in Women With Obesity and Gestational Diabetes Mellitus.

Correction: Advanced care planning during the COVID-19 pandemic: ceiling of care decisions and their implications for observational data.

PIEZO1 and PECAM1 interact at cell-cell junctions and partner in endothelial force sensing.

Independent endothelial functions of PIEZO1 and TRPV4 in hepatic portal vein and predominance of PIEZO1 in mechanical and osmotic stress.

Relationship Among Diabetes, Obesity, and Cardiovascular Disease Phenotypes: A UK Biobank Cohort Study.

Association Between Type 2 Diabetes and Changes in Myocardial Structure, Contractile Function, Energetics, and Blood Flow Before and After Aortic Valve Replacement in Patients With Severe Aortic Stenosis.

Molecular mechanisms of diabetic heart disease: Insights from transcriptomic technologies.

Inflammation, infection, and cardiovascular risk.