Stephen Wheatcroft

IGF-binding protein-2 protects against the development of obesity and insulin resistance.

Inter-subject differences in constitutive expression levels of the clock gene in man.

The impact of insulin resistance on endothelial function, progenitor cells and repair.

Insulin resistance and endothelial cell dysfunction: studies in mammalian models.

Effect of endothelium-specific insulin resistance on endothelial function in vivo.

Diabetes mellitus and mortality after acute coronary syndrome as a first or recurrent cardiovascular event.

IGF-dependent and IGF-independent actions of IGF-binding protein-1 and -2: implications for metabolic homeostasis.

Vascular insulin-like growth factor-I resistance and diet-induced obesity.

Effects of insulin resistance on endothelial progenitor cells and vascular repair.

Human exercise-induced circulating progenitor cell mobilization is nitric oxide-dependent and is blunted in South Asian men.

Pregnenolone sulphate- and cholesterol-regulated TRPM3 channels coupled to vascular smooth muscle secretion and contraction.

Scavenger receptors and their potential as therapeutic targets in the treatment of cardiovascular disease.

Insulin resistance impairs circulating angiogenic progenitor cell function and delays endothelial regeneration.

OBTAIN: a study of the occurrence of bleeding and thrombosis during anti-platelet therapy in non-cardiac surgery.

Changing characteristics and mode of death associated with chronic heart failure caused by left ventricular systolic dysfunction: a study across therapeutic eras.

The insulin-like growth factor-1 receptor is a negative regulator of nitric oxide bioavailability and insulin sensitivity in the endothelium.

Increasing circulating IGFBP1 levels improves insulin sensitivity, promotes nitric oxide production, lowers blood pressure, and protects against atherosclerosis.

Novel role of the IGF-1 receptor in endothelial function and repair: studies in endothelium-targeted IGF-1 receptor transgenic mice.

The S100A6 calcium-binding protein regulates endothelial cell-cycle progression and senescence.

A heat-shock protein axis regulates VEGFR2 proteolysis, blood vessel development and repair.

Diabetes mellitus is associated with adverse prognosis in chronic heart failure of ischaemic and non-ischaemic aetiology.

Nox2 NADPH oxidase has a critical role in insulin resistance-related endothelial cell dysfunction.

Diurnal variation in vascular and metabolic function in diet-induced obesity: divergence of insulin resistance and loss of clock rhythm.

Teaching an old drug new tricks: can paroxetine ease the burden of cardiovascular disease in diabetes?

Ankle pressures in UK South Asians with diabetes mellitus: a case control study.

Endothelium-specific insulin resistance leads to accelerated atherosclerosis in areas with disturbed flow patterns: a role for reactive oxygen species.

Vascular endothelial growth factor A-stimulated signaling from endosomes in primary endothelial cells.

Restoring Akt1 activity in outgrowth endothelial cells from South Asian men rescues vascular reparative potential.

VEGF-A isoforms differentially regulate ATF-2-dependent VCAM-1 gene expression and endothelial-leukocyte interactions.

Haploinsufficiency of the insulin-like growth factor-1 receptor enhances endothelial repair and favorably modifies angiogenic progenitor cell phenotype.

In silico design and biological evaluation of a dual specificity kinase inhibitor targeting cell cycle progression and angiogenesis.

Oxidized LDL activates blood platelets through CD36/NOX2-mediated inhibition of the cGMP/protein kinase G signaling cascade.

Vascular endothelial growth factors: multitasking functionality in metabolism, health and disease.

VEGF-A isoform-specific regulation of calcium ion flux, transcriptional activation and endothelial cell migration.

Scavenger receptor structure and function in health and disease.

Detection and Quantification of Vascular Endothelial Growth Factor Receptor Tyrosine Kinases in Primary Human Endothelial Cells.

Clinical and Preclinical Use of LOX-1-Specific Antibodies in Diagnostics and Therapeutics.

VEGFR2 Trafficking, Signaling and Proteolysis is Regulated by the Ubiquitin Isopeptidase USP8.

Endothelial IGF-1 Receptor Signalling in Diabetes and Insulin Resistance.

VEGF-A isoforms program differential VEGFR2 signal transduction, trafficking and proteolysis.

How We Measure Heart Rate: Does it Matter?

Selective Enhancement of Insulin Sensitivity in the Endothelium In Vivo Reveals a Novel Proatherosclerotic Signaling Loop.

Insulin-Like Growth Factor Binding Protein 1 Could Improve Glucose Regulation and Insulin Sensitivity Through Its RGD Domain.

Inhibition of plasmin-mediated TAFI activation may affect development but not progression of abdominal aortic aneurysms.

Assessing Coronary Blood Flow Physiology in the Cardiac Catheterisation Laboratory.

Ubiquitination of basal VEGFR2 regulates signal transduction and endothelial function.

Endothelial SHIP2 Suppresses Nox2 NADPH Oxidase-Dependent Vascular Oxidative Stress, Endothelial Dysfunction, and Systemic Insulin Resistance.

Piezo1 channels sense whole body physical activity to reset cardiovascular homeostasis and enhance performance.

Clinical outcomes following primary percutaneous coronary intervention for ST-elevation myocardial infarction according to sex and race.

Insulinlike Growth Factor-Binding Protein-1 Improves Vascular Endothelial Repair in Male Mice in the Setting of Insulin Resistance.

Endothelial Insulin Receptor Restoration Rescues Vascular Function in Male Insulin Receptor Haploinsufficient Mice.

The insulin like growth factor and binding protein family: Novel therapeutic targets in obesity & diabetes.

TRPC5 ion channel permeation promotes weight gain in hypercholesterolaemic mice.

Insulin-like growth factor binding proteins and angiogenesis: from cancer to cardiovascular disease.

Tpl2 is required for VEGF-A-stimulated signal transduction and endothelial cell function.

Real-world comparison of clopidogrel, prasugrel and ticagrelor in patients undergoing primary percutaneous coronary intervention.

Prescribing diabetes medication for cardiovascular risk reduction in patients admitted with acute coronary syndromes: a survey of cardiologists' attitudes and practice.

IGFBP-1 in Cardiometabolic Pathophysiology-Insights From Loss-of-Function and Gain-of-Function Studies in Male Mice.

Divergent effects of genetic and pharmacological inhibition of Nox2 NADPH oxidase on insulin resistance-related vascular damage.

Direct oral anticoagulants compared to vitamin K antagonist for the management of left ventricular thrombus.

Unique Transcriptome Signature Distinguishes Patients With Heart Failure With Myopathy.

Advantages of CEMiTool for gene co-expression analysis of RNA-seq data.

Endothelial IGF-1 receptor mediates crosstalk with the gut wall to regulate microbiota in obesity.

Endothelial Insulin Receptors Promote VEGF-A Signaling via ERK1/2 and Sprouting Angiogenesis.

Novel Paracrine Action of Endothelium Enhances Glucose Uptake in Muscle and Fat.

Pericyte Insulin Receptors Modulate Retinal Vascular Remodeling and Endothelial Angiopoietin Signaling.

Meta-Analysis Comparing 10-Year Mortality Following Percutaneous Coronary Intervention or Coronary Artery Bypass Grafting in Left Main Stem or Multivessel Coronary Artery Disease.

Cixutumumab reveals a critical role for IGF-1 in adipose and hepatic tissue remodelling during the development of diet-induced obesity.

Randomized, Placebo-Controlled Phase 2b Study to Evaluate the Safety and Efficacy of Recombinant Human Lecithin Cholesterol Acyltransferase in Acute ST-Segment-Elevation Myocardial Infarction: Results of REAL-TIMI 63B.

Meta-Analysis Comparing Clinical Outcomes of Fractional-Flow-Reserve- and Angiography-Guided Multivessel Percutaneous Coronary Intervention.

Association between operator volume and mortality in primary percutaneous coronary intervention.

Safety and efficacy of interrupting dual antiplatelet therapy one month following percutaneous coronary intervention: a meta-analysis of randomized controlled trials.

Management of non-ST-segment elevation myocardial infarction in patients aged ≥ 80 years: a meta-analysis of randomized controlled trials.

Imaging Real-Time Coronary Anatomy Using a Three-Dimensional Electrophysiology Mapping System.

Fractional Flow Reserve versus Angiography-Guided Management of Coronary Artery Disease: A Meta-Analysis of Contemporary Randomised Controlled Trials.

Improving the management of left ventricular thrombus in a tertiary cardiology centre: a quality improvement project.

Clinical validation and evaluation of a novel six-lead handheld electrocardiogram recorder compared to the 12-lead electrocardiogram in unselected cardiology patients (EVALECG Cardio).

Transcoronary electrophysiological parameters in patients undergoing elective and acute coronary intervention.

Loss of IGFBP2 mediates alveolar type 2 cell senescence and promotes lung fibrosis.

Relationship Among Diabetes, Obesity, and Cardiovascular Disease Phenotypes: A UK Biobank Cohort Study.

Intravascular Imaging-Guided Versus Angiography-Guided Percutaneous Coronary Intervention on Medium-Term Outcomes: A Contemporary Meta-Analysis of Randomized Controlled Trials.

Coronary Guidewires in Temporary Cardiac Pacing and Assessment of Myocardial Viability: Current Perspectives and Future Directions.

Sodium-glucose cotransporter 2 inhibitors influence skeletal muscle pathology in patients with heart failure and reduced ejection fraction.