Kam W. Leong

Autologous fixed tumor vaccine: a formulation with cytokine-microparticles for protective immunity against recurrence of human hepatocellular carcinoma.

Polyphosphoester microspheres for sustained release of biologically active nerve growth factor.

Intranasal gene transfer by chitosan-DNA nanospheres protects BALB/c mice against acute respiratory syncytial virus infection.

New polyphosphoramidate with a spermidine side chain as a gene carrier.

Adhesion contact dynamics of HepG2 cells on galactose-immobilized substrates.

Preparation and characterization of polypseudorotaxanes based on block-selected inclusion complexation between poly(propylene oxide)-poly(ethylene oxide)-poly(propylene oxide) triblock copolymers and alpha-cyclodextrin.

Microcapsules with improved mechanical stability for hepatocyte culture.

Peripheral nerve regeneration with sustained release of poly(phosphoester) microencapsulated nerve growth factor within nerve guide conduits.

Polyphosphoesters in drug and gene delivery.

Injectable drug-delivery systems based on supramolecular hydrogels formed by poly(ethylene oxide)s and alpha-cyclodextrin.

Chitosan nanoparticles containing plasmid DNA encoding house dust mite allergen, Der p 1 for oral vaccination in mice.

In vivo US monitoring of catheter-based vascular delivery of gene microspheres in pigs: feasibility.

Multifunctional nanorods for gene delivery.

Poly(D,L-lactide-co-ethyl ethylene phosphate)s as new drug carriers.

Use of ultrathin shell microcapsules of hepatocytes in bioartificial liver-assist device.

Effect of side-chain structures on gene transfer efficiency of biodegradable cationic polyphosphoesters.

Thermally responsive polymeric micellar nanoparticles self-assembled from cholesteryl end-capped random poly(N-isopropylacrylamide-co-N,N-dimethylacrylamide): synthesis, temperature-sensitivity, and morphologies.

Galactosylated PVDF membrane promotes hepatocyte attachment and functional maintenance.

High density of immobilized galactose ligand enhances hepatocyte attachment and function.

Peripheral nerve regeneration by microbraided poly(L-lactide-co-glycolide) biodegradable polymer fibers.

A nonlinear hyperelastic mixture theory model for anisotropy, transport, and swelling of annulus fibrosus.

Water-soluble and nonionic polyphosphoester: synthesis, degradation, biocompatibility and enhancement of gene expression in mouse muscle.

Phase II randomized trial of autologous formalin-fixed tumor vaccine for postsurgical recurrence of hepatocellular carcinoma.

Photo-crosslinkable microcapsules formed by polyelectrolyte copolymer and modified collagen for rat hepatocyte encapsulation.

Bioadhesive characterization of poly(methylidene malonate 2.12) microparticle on model extracellular matrix.

The effect of the degree of chitosan deacetylation on the efficiency of gene transfection.

In vitro release of vascular endothelial growth factor from gadolinium-doped biodegradable microspheres.

Poly(phosphoester) ionomers as tissue-engineering scaffolds.

Evaluation of collagen and methylated collagen as gene carriers.

Biodegradable polyphosphoester micelles for gene delivery.

Adhesion contact dynamics of primary hepatocytes on poly(ethylene terephthalate) surface.

Polyelectrolyte complex films derived from polyethyleneoxide-maleic acid copolymer and chitosan: preparation and characterization.

Encapsulation of biologics in self-assembled fibers as biostructural units for tissue engineering.

Stable immobilization of rat hepatocyte spheroids on galactosylated nanofiber scaffold.

Coculture of mesenchymal stem cells and respiratory epithelial cells to engineer a human composite respiratory mucosa.

Ternary complexes comprising polyphosphoramidate gene carriers with different types of charge groups improve transfection efficiency.

In vitro gene delivery using polyamidoamine dendrimers with a trimesyl core.

Formulation of chitosan-DNA nanoparticles with poly(propyl acrylic acid) enhances gene expression.

Galactosylated ternary DNA/polyphosphoramidate nanoparticles mediate high gene transfection efficiency in hepatocytes.

MR imaging of biodegradable polymeric microparticles: a potential method of monitoring local drug delivery.

Biodegradable poly(terephthalate-co-phosphate)s: synthesis, characterization and drug-release properties.

Nanopattern-induced changes in morphology and motility of smooth muscle cells.

pH responsive adhesion of phospholipid vesicle on poly(acrylic acid) cushion grafted to poly(ethylene terephthalate) surface.

Controlled release from fibers of polyelectrolyte complexes.

Polyethylenimine-grafted multiwalled carbon nanotubes for secure noncovalent immobilization and efficient delivery of DNA.

Sustained release of proteins from electrospun biodegradable fibers.

Engineering microenvironment for expansion of sensitive anchorage-dependent mammalian cells.

Temperature-responsive hydroxybutyl chitosan for the culture of mesenchymal stem cells and intervertebral disk cells.

Biodegradable and photocrosslinkable polyphosphoester hydrogel.

Targeted tumor cell death induced by autologous tumor-specific T lymphocyte recognition of wild-type p53-derived peptides.

Micellization phenomena of biodegradable amphiphilic triblock copolymers consisting of poly(beta-hydroxyalkanoic acid) and poly(ethylene oxide).

Design of polyphosphoester-DNA nanoparticles for non-viral gene delivery.

Design of Polyphosphoester-DNA Nanoparticles for Non-Viral Gene Delivery.

Proliferation and differentiation of human embryonic germ cell derivatives in bioactive polymeric fibrous scaffold.

Evaluation of hyperbranched poly(amino ester)s of amine constitutions similar to polyethylenimine for DNA delivery.

Controlled release of heparin from poly(epsilon-caprolactone) electrospun fibers.

Surface-immobilization of adhesion peptides on substrate for ex vivo expansion of cryopreserved umbilical cord blood CD34+ cells.

Chitosan-g-PEG/DNA complexes deliver gene to the rat liver via intrabiliary and intraportal infusions.

Galactosylated poly(vinylidene difluoride) hollow fiber bioreactor for hepatocyte culture.

PEI-g-chitosan, a novel gene delivery system with transfection efficiency comparable to polyethylenimine in vitro and after liver administration in vivo.

Nonviral gene delivery from nonwoven fibrous scaffolds fabricated by interfacial complexation of polyelectrolytes.

Dynamic and static light scattering studies on self-aggregation behavior of biodegradable amphiphilic poly(ethylene oxide)-poly[(R)-3-hydroxybutyrate]-poly(ethylene oxide) triblock copolymers in aqueous solution.

Self-assembled supramolecular hydrogels formed by biodegradable PEO-PHB-PEO triblock copolymers and alpha-cyclodextrin for controlled drug delivery.

Inducing hepatic differentiation of human mesenchymal stem cells in pellet culture.

Radio-responsive gene therapy for malignant glioma cells without the radiosensitive promoter: Caspase-3 gene therapy combined with radiation.

Three-dimensional co-culture of rat hepatocyte spheroids and NIH/3T3 fibroblasts enhances hepatocyte functional maintenance.

Enhanced extracellular matrix production and differentiation of human embryonic germ cell derivatives in biodegradable poly(epsilon-caprolactone-co-ethyl ethylene phosphate) scaffold.

Enhancing efficacy of HIV gag DNA vaccine by local delivery of GM-CSF in murine and macaque models.

Expansion of engrafting human hematopoietic stem/progenitor cells in three-dimensional scaffolds with surface-immobilized fibronectin.

Natural polymers for gene delivery and tissue engineering.

Hyperbranched poly(amino ester)s with different terminal amine groups for DNA delivery.

Surface-aminated electrospun nanofibers enhance adhesion and expansion of human umbilical cord blood hematopoietic stem/progenitor cells.

Interaction of human mesenchymal stem cells with disc cells: changes in extracellular matrix biosynthesis.

Proliferation and differentiation of human mesenchymal stem cell encapsulated in polyelectrolyte complexation fibrous scaffold.

In vivo evaluation of plasmid DNA encoding OP-1 protein for spine fusion.

Co-culture of umbilical cord blood CD34+ cells with human mesenchymal stem cells.

Small intestinal submucosa as a potential bioscaffold for intervertebral disc regeneration.

Evaluating the intracellular stability and unpacking of DNA nanocomplexes by quantum dots-FRET.

Dynamics of smooth muscle cell deadhesion from thermosensitive hydroxybutyl chitosan.

Biomaterials approach to expand and direct differentiation of stem cells.

Significance of synthetic nanostructures in dictating cellular response.

Effects of MIP-1 alpha, MIP-3 alpha, and MIP-3 beta on the induction of HIV Gag-specific immune response with DNA vaccines.

Chitosan-DNA nanoparticles delivered by intrabiliary infusion enhance liver-targeted gene delivery.

In vitro chondrogenesis of mesenchymal stem cells in recombinant silk-elastinlike hydrogels.

Synthetic nanostructures inducing differentiation of human mesenchymal stem cells into neuronal lineage.

Tissue-engineered bone formation with gene transfer and mesenchymal stem cells in a minimally invasive technique.

Tissue compatibility of interfacial polyelectrolyte complexation fibrous scaffold: evaluation of blood compatibility and biocompatibility.

Hepatic differentiation potential of commercially available human mesenchymal stem cells.

A dual-functional fibrous scaffold enhances P450 activity of cultured primary rat hepatocytes.

Functional nanofiber scaffolds with different spacers modulate adhesion and expansion of cryopreserved umbilical cord blood hematopoietic stem/progenitor cells.

Quantum-dots-FRET nanosensors for detecting unamplified nucleic acids by single molecule detection.

Chitosan nanoparticles for oral drug and gene delivery.

The effect of the alignment of electrospun fibrous scaffolds on Schwann cell maturation.

In vivo wound healing of diabetic ulcers using electrospun nanofibers immobilized with human epidermal growth factor (EGF).

Quantitative comparison of intracellular unpacking kinetics of polyplexes by a model constructed from quantum dot-FRET.

Label-free, high-throughput measurements of dynamic changes in cell nuclei using angle-resolved low coherence interferometry.

Poly(ethylene imine)-g-chitosan using EX-810 as a spacer for nonviral gene delivery vectors.

Radiation-inducible caspase-8 gene therapy for malignant brain tumors.

Myogenic Induction of Aligned Mesenchymal Stem Cell Sheets by Culture on Thermally Responsive Electrospun Nanofibers.

Aligned Protein-Polymer Composite Fibers Enhance Nerve Regeneration: A Potential Tissue-Engineering Platform.

Gene transfer to hemophilia A mice via oral delivery of FVIII-chitosan nanoparticles.

Viscoelastic behaviour of human mesenchymal stem cells.

Engineering strategies to enhance nanoparticle-mediated oral delivery.

Mechanical properties of single electrospun drug-encapsulated nanofibres.

The convergence of quantum-dot-mediated fluorescence resonance energy transfer and microfluidics for monitoring DNA polyplex self-assembly in real time.

Sustained viral gene delivery through core-shell fibers.

Electrohydrodynamics: A facile technique to fabricate drug delivery systems.

Balancing protection and release of DNA: tools to address a bottleneck of non-viral gene delivery.

Effect of Electromechanical Stimulation on the Maturation of Myotubes on Aligned Electrospun Fibers.

Development of universal antidotes to control aptamer activity.

Mast cell-derived particles deliver peripheral signals to remote lymph nodes.

Nanotopography-induced changes in focal adhesions, cytoskeletal organization, and mechanical properties of human mesenchymal stem cells.

Transport of chitosan-DNA nanoparticles in human intestinal M-cell model versus normal intestinal enterocytes.

Characterization of topographical effects on macrophage behavior in a foreign body response model.

Microscale oral delivery devices incorporating nanoparticles.

Simultaneous Non-invasive Analysis of DNA Condensation and Stability by Two-step QD-FRET.

Low oxygen tension and synthetic nanogratings improve the uniformity and stemness of human mesenchymal stem cell layer.

Dual-sensitive micellar nanoparticles regulate DNA unpacking and enhance gene-delivery efficiency.

Electrosprayed core-shell microspheres for protein delivery.

Polymer hydrogels: Chaperoning vaccines.

Implantation of mouse embryonic stem cell-derived cardiac progenitor cells preserves function of infarcted murine hearts.

Quantum dot-based theranostics.

Nanoscale surfacing for regenerative medicine.

Bioavailability of metalloporphyrin-based SOD mimics is greatly influenced by a single charge residing on a Mn site.

Efficacy of engineered FVIII-producing skeletal muscle enhanced by growth factor-releasing co-axial electrospun fibers.

Transient depletion of kupffer cells leads to enhanced transgene expression in rat liver following retrograde intrabiliary infusion of plasmid DNA and DNA nanoparticles.

Simultaneous delivery of siRNA and paclitaxel via a "two-in-one" micelleplex promotes synergistic tumor suppression.

Deformation of stem cell nuclei by nanotopographical cues.

High-throughput screening of microscale pitted substrate topographies for enhanced nonviral transfection efficiency in primary human fibroblasts.

Emerging links between surface nanotechnology and endocytosis: impact on nonviral gene delivery.

Engineering of a microfluidic cell culture platform embedded with nanoscale features.

Tuning physical properties of nanocomplexes through microfluidics-assisted confinement.

Diverse functions of cationic Mn(III) N-substituted pyridylporphyrins, recognized as SOD mimics.

Dynamic topographical control of mesenchymal stem cells by culture on responsive poly(ε-caprolactone) surfaces.

Stem cell differentiation indicated by noninvasive photonic characterization and fractal analysis of subcellular architecture.

Uptake and intracellular fate of multifunctional nanoparticles: a comparison between lipoplexes and polyplexes via quantum dot mediated Förster resonance energy transfer.

Three-dimensional culture of rabbit nucleus pulposus cells in collagen microspheres.

Nucleic acid-binding polymers as anti-inflammatory agents.

Mechanical behavior of human embryonic stem cell pellet under unconfined compression.

Cytotoxic effects of Mn(III) N-alkylpyridylporphyrins in the presence of cellular reductant, ascorbate.

Pluripotent stem cell-derived cardiac tissue patch with advanced structure and function.

Detection of single enzymatic events in rare or single cells using microfluidics.

Nucleic acid-binding polymers as anti-inflammatory agents: reducing the danger of nuclear attack.

Microfluidics-mediated isothermal detection of enzyme activity at the single molecule level.

Synthetic mast-cell granules as adjuvants to promote and polarize immunity in lymph nodes.

Comparative study of nanoparticle-mediated transfection in different GI epithelium co-culture models.